A5025141150- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- DNA and Biological Computing
- Advanced biosensing and bioanalysis techniques
- Lymphoma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- PARP inhibition in cancer therapy
- DNA and Nucleic Acid Chemistry
- Image and Object Detection Techniques
- Modular Robots and Swarm Intelligence
- Lung Cancer Treatments and Mutations
- Industrial Vision Systems and Defect Detection
- Biliary and Gastrointestinal Fistulas
- Advanced Breast Cancer Therapies
- RNA Interference and Gene Delivery
- Esophageal and GI Pathology
- Chronic Lymphocytic Leukemia Research
- Image Processing Techniques and Applications
- Remote Sensing and Land Use
- Evolutionary Algorithms and Applications
- Digital Imaging for Blood Diseases
- Genetic factors in colorectal cancer
- Antibiotic Use and Resistance
- Metabolomics and Mass Spectrometry Studies
- Advanced Image Fusion Techniques
Benazir Bhutto Hospital
2022-2024
Mustansiriyah University
2024
Rawalpindi Medical University
2020-2023
Kinnaird College for Women University
2023
UC San Diego Health System
2021
Moores Cancer Center
2018-2020
Holy Family Hospital
2020
Foundation University Medical College
2020
University of California, San Diego
2019
University of Technology Malaysia
2008-2012
Abstract Higher tumor mutational burden (TMB) has been correlated with response to checkpoint blockade immunotherapy. However, it is unclear whether TMB independently serves as a prognostic biomarker for outcomes in immunotherapy-naïve patients. Here, we evaluated the relationship between and overall survival 1,415 patients diverse advanced malignancies. was studied both tiered variable (low ≤5 mutations/Mb, intermediate >5 <20, high ≥20 <50, very ≥50) continuous...
BACKGROUNDAlthough CDK4/6 inhibitors are an established treatment for hormone receptor-positive, HER2-negative metastatic breast cancers, their benefit in other malignancies remains limited.METHODSWe investigated factors associated with clinical outcomes from inhibitor-based therapy among patients G1/S phase cell-cycle alterations (CDK4/6 amplifications, CCND1/2/3 or CDKN2A/B alterations).RESULTSOverall, 2457 diverse solid tumors that underwent clinical-grade, next-generation sequencing...
Introduction: Minimally invasive surgery (MIS) has gained global recognition for its superior outcomes, including reduced postoperative pain, shorter recovery times, and improved cosmetic results compared to open surgery. However, adoption in resource-limited settings remains a challenge due high equipment costs, limited training opportunities, patient perceptions. This study aimed evaluate the trends of MIS versus over eight years public sector hospital Pakistan. Methods: A retrospective...
Problematic over usage of smartphones has led to various deteriorating effects including poor sleep quality. Screen exposure, especially near bedtime, directly leads We aimed measure smartphone screen-time (ST) statistics the participants using a application. Furthermore, we assess quality Pittsburgh index (PSQI), and investigate association between ST & PSQI.This descriptive cohort study was conducted among 280 students MBBS at Rawalpindi Medical University for period 1 month (30 days)....
RAS alterations are often found in difficult-to-treat malignancies and considered "undruggable." To better understand the clinical correlates coaltered genes of alterations, we used targeted next-generation sequencing (NGS) to analyze 1,937 patients with diverse cancers. Overall, 20.9% cancers (405/1,937) harbored alterations. Most RAS-altered cases had genomic coalterations (95.3%, median: 3, range: 0-51), involving implicated oncogenic signals: PI3K pathway (31.4% 405 cases), cell cycle...
Background Gram-negative bacteria are frequently involved in nosocomial infections. These have a particular tendency to develop antibiotic resistance and may become extensively drug-resistant (XDR). This study aimed detect the prevalence of XDR tertiary care hospital Pakistan. Materials methods Clinical samples were obtained from patients admitted different inpatient wards sent for microbial analysis culture. Antibiotic susceptibility testing isolates was performed by disk diffusion method...
Hybridization between a DNA sequence and its base-pairing complement is crucial in computing to retrieve the information stored sequences operate computation processes. Therefore, much works have focused on designing for reliable molecular computation. In this paper, Ant Colony System (ACS) proposed solve design problem. ACS, which based Optimization (ACO) an improvement of (AS) that uses some agents obtain solutions pheromone their colony. The problem modeled by four nodes, representing...
In DNA based computation and nanotechnology, the design of good sequences has turned out to be an elementary problem one most practical important research topics. Although is dependent on protocol biological experiments, it highly required establish a method for systematic sequences, which could applied various constraints. Therefore, much work focused designing avoid incorrect or undesirable computations. this paper, model particle swarm optimization (PSO) implementation proposed solve...
The case highlights the importance of decisive action in addressing large gallstones causing gastric outlet obstruction. chosen single-stage surgical approach reflects need to manage both obstruction and gallstone simultaneously.
Problem statement: In DNA based computation and nanotechnology, the design of good sequences has turned out to be an essential problem one most practical important research topics. Basically, sequence is a multi-objective it can evaluated using four objective functions, namely, Hmeasure, similarity, continuity hairpin. Approach: There are several ways solve problem, however, in order evaluate correctness PSO algorithm design, this converted into single problem. Particle Swarm Optimization...
Image difference operation is frequently used in automated printed circuit board (PCB) inspection system as well many other image processing applications. During the implementation, this brings along unwanted noise due to misalignment and uneven binarization. Thus, paper proposes a method eliminate, if possible, or reduce much possible such during computation of defect detection. This template PCB tested input. subtraction will be applied between images. The results applying proposed showed...
Deoxyribonucleic Acid (DNA) has certain unique properties such as self-assembly and self-complementary in hybridization, which are important many DNA-based technologies. Hybridization of DNA can be controlled by properly designing sequences. In this study, sequences designed that each sequence uniquely hybridizes to its complementary sequence, but not any other Vector evaluated particle swarm optimization (VEPSO) is employed solve the design problem minimizing four objective functions,...
DNA computing is a new paradigm which uses bio-molecular as information storage media and biochemical tools processing operators. It has shows many successful promising results for various applications. Since reactions are probabilistic reactions, it can cause the different same situations, be regarded errors in computation. To overcome drawbacks, much works have focused to design error-minimized sequences improve reliability of computing. In this research, Population-based ACO (P-ACO)...
In DNA based computation and nanotechnology, the design of good sequences has turned out to be an elementary problem one most practical important research topics. Although is dependent on protocol biological experiments, it highly required establish a method for systematic sequences, which could applied various constraints. Basically, fitness can evaluated using four objective functions, namely, similarity, Hmeasure, continuity hairpin. this paper, binary particle swarm optimization (BinPSO)...
In remote sensing images, numerous image fusion methods have been developed to produce high-resolution multispectral images from (MS) and panchromatic (PAN) image. This work suggests suitable algorithm that maintains the spectral spatial information content overcome degradation of satellite images. Three statistical are used implement process based on Discrete wavelet transform (DWT). Absolute Max, Mean Standard Deviation Simple Linear Regression (SLR). The DWT applied both MS bands PAN high...