A5053824837- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Pain Management and Opioid Use
- Hormonal and reproductive studies
- Artificial Intelligence in Healthcare
- Genetic factors in colorectal cancer
- Opioid Use Disorder Treatment
- Statistical Methods in Clinical Trials
- Global Cancer Incidence and Screening
- Advanced Causal Inference Techniques
- Palliative Care and End-of-Life Issues
- Lymphoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Bladder and Urothelial Cancer Treatments
- Economic and Financial Impacts of Cancer
- LGBTQ Health, Identity, and Policy
- PARP inhibition in cancer therapy
- Multiple and Secondary Primary Cancers
- Pharmacological Effects and Toxicity Studies
- Sexual Differentiation and Disorders
University of California, San Diego
2015-2025
Naval Medical Center San Diego
2025
UC San Diego Health System
2019-2024
San Francisco VA Medical Center
2022-2024
VA San Diego Healthcare System
2024
University of San Diego
2024
University of California, Irvine
2021-2023
Digital Health Cooperative Research Centre
2022
Digital China Health (China)
2022
Moores Cancer Center
2017-2020
Background African American (AA) men in the general US population are more than twice as likely to die of prostate cancer (PC) compared with non‐Hispanic white (NHW) men. The authors hypothesized that receiving care through Veterans Affairs (VA) health system, an equal‐access medical would attenuate this disparity. Methods A longitudinal, centralized database >20 million veterans was used assemble a cohort 60,035 (18,201 AA [30.3%] and 41,834 NHW [69.7%]) who were diagnosed PC between...
Abstract Background Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer have revolutionized the treatment of tumors. The influence host germline genetics interaction tumor neoantigens remains poorly defined. We sought to determine between mutational burden (TMB) ability a patient’s major histocompatibility complex class...
Importance There is no consensus in prostate-specific antigen (PSA) screening guidelines regarding transgender women despite their known prostate cancer risk. Objective To identify factors associated with recent (within the last 2 years) PSA compared cisgender men. Design, Setting, and Participants This case-control study used data from 2018 2020 Behavioral Risk Factor Surveillance System (BRFSS) surveys to characterize rates of for within past years multivariable logistic regressions among...
Abstract Higher tumor mutational burden (TMB) has been correlated with response to checkpoint blockade immunotherapy. However, it is unclear whether TMB independently serves as a prognostic biomarker for outcomes in immunotherapy-naïve patients. Here, we evaluated the relationship between and overall survival 1,415 patients diverse advanced malignancies. was studied both tiered variable (low ≤5 mutations/Mb, intermediate >5 <20, high ≥20 <50, very ≥50) continuous...
Hydrophobic neoantigens are more immunogenic because they better presented by the major histocompatibility complex and recognized T cells. Tumor cells can evade immune response expressing checkpoints such as programmed death ligand 1. Checkpoint blockade reactivates recognition be effective in diseases melanoma, which harbors a high tumor mutational burden (TMB). Cancers presenting low or intermediate TMB also respond to checkpoint blockade, albeit less frequently, suggesting need for...
Abstract Background Although opioids play a critical role in the management of cancer pain, ongoing opioid epidemic has raised concerns regarding their persistent use and abuse. We lack data-driven tools oncology to understand risk adverse opioid-related outcomes. This project seeks identify clinical factors create score help patients at Methods Within cohort 106 732 military veteran survivors diagnosed between 2000 2015, we determined rates posttreatment use, diagnoses abuse or dependence,...
Importance The US Preventive Services Task Force guidelines advise against prostate-specific antigen (PSA) screening for prostate cancer in males older than 69 years due to the risk of false-positive results and overdiagnosis indolent disease. However, this low-value PSA aged 70 or remains common. Objective To characterize factors associated with older. Design, Setting, Participants This survey study used data from 2020 Behavioral Risk Factor Surveillance System (BRFSS), a nationwide annual...
The standard treatment paradigm for muscle invasive bladder cancer has been neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy. However, efforts are ongoing to personalize incorporating biomarkers better guide selection. In addition, preservation strategies aimed at avoiding cystectomy in well-selected patients. Similarly, the metastatic urothelial space, frontline option of platinum-based changed with availability data from EV-302 trial, making combination enfortumab...
We aimed to assess the utility of a novel, noninvasive method detecting genomic alterations in patients with gastrointestinal malignancies, i.e., use liquid biopsies obtain blood-derived circulating tumor DNA (ctDNA) through an analysis landscape ctDNA (68 genes) from 213 advanced cancers. The most common cancer types were colorectal adenocarcinoma (N = 55; 26%), appendiceal 46; 22%), hepatocellular carcinoma 31; 15%), and pancreatic ductal 25; 12%). majority (58%) had ≥1 characterized...
Minority race and lower socioeconomic status are associated with rates of opioid prescription undertreatment pain in multiple noncancer healthcare settings. It is not known whether these differences prescribing exist among patients undergoing cancer treatment.
Abstract We would like to thank Dr Oleribe for their interest in the study, “Predicting Persistent Opioid Use, Abuse, and Toxicity Among Cancer Survivors”. In critical appraisal, author concludes that there is an increased rate of persistent opioid use among Black veterans because proportion with who were was higher than African American on a census bureau report veterans. While we appreciate author’s investigation into potential racial disparities adverse outcomes, do not agree methodology...
621 Background: Testicular cancer is one of the most common and curable malignancies in young men, with a 5 year survival rate 95%. Limited research has explored long-term outcomes among Black given rarity disease this demographic. Our study aims to assess potential racial differences overall (OS) cancer-specific mortality (CSM) testicular patients using large, equal access nationwide Veterans Affairs (VA) database, focusing on self-identified White race. Methods: This retrospective analyzed...
348 Background: Biochemical recurrence (BCR) of prostate cancer following radiation therapy often does not result in clinically significant events, but a subset patients may be at higher risk developing metastatic disease or death. Identifying these is critical for clinical decision making, unlike the post-prostatectomy setting, no method has been externally validated BCR after therapy. This study characterized outcomes post-radiation and proposed stratification heuristic. Methods: was...
ABSTRACT Background The 5‐year survival rate for patients with testicular germ cell tumors (TC) is excellent. However, these survivors are at an increased risk metabolic syndrome (MetS), a significant source of morbidity and precursor to cardiovascular disease. This study investigates the incidence MetS in TC compared matched controls. Methods A retrospective analysis was conducted using Veterans Affairs national database. between 2021 7595 identified via diagnostic codes medication use,...
Importance Prostate cancer in Black men compared with White may be more sensitive to radiation therapy resulting better outcomes equal-access settings. The of androgen-deprivation (ADT) vs itself remains uncharacterized. Objectives To quantify any outcome modification by receipt ADT on the association between race and prostate following therapy. Design, Setting, Participants This was a retrospective, nationwide cohort study patients treated US Veterans Healthcare system 2000 2020 receiving...
Abstract Background Despite the rise in gender‐affirming care, our understanding of prostate cancer (PCa) transgender women (TGW) remains its infancy. Health disparities and lack PCa awareness screening are possible barriers to providing quality care for this population. In addition, implication hormonal manipulation aggressiveness TGW is yet be determined. Here, study sought compare oncological characteristics survival outcomes between cisgender (CG) patients with via two national data...