A5031868280- BRCA gene mutations in cancer
- Oral microbiology and periodontitis research
- Human Health and Disease
- Ovarian cancer diagnosis and treatment
- Folate and B Vitamins Research
- Receptor Mechanisms and Signaling
- Digestive system and related health
- Vitamin D Research Studies
- Free Radicals and Antioxidants
- Metabolism and Genetic Disorders
- Salivary Gland Disorders and Functions
- Nutrition, Genetics, and Disease
- Sex and Gender in Healthcare
- dental development and anomalies
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Computational Drug Discovery Methods
- Dental Health and Care Utilization
- Celiac Disease Research and Management
- Intestinal Malrotation and Obstruction Disorders
- Pregnancy and preeclampsia studies
- Cancer Risks and Factors
- Glutathione Transferases and Polymorphisms
- PARP inhibition in cancer therapy
National Academy of Medical Sciences of Ukraine
2018-2021
Ministry of Health
2020
Shupyk National Healthcare University of Ukraine
2017
The scientific literature presents contradictory data about influence of folate metabolism genes polymorphism on development risk reproductive disorders. aim the study was to determine role MTHFR, MTRR, MTR1 gene in disorders by evaluation genetic models inheritance. 658 patients with from all Ukrainian regions were examined. population studies presented online resource (1000 genomes) served as comparison group. There no reliable for polymorphic variants MTHFR gene. We identified 3 and 4...
Bronchial asthma (BA) has a polygenic nature, and the onset of its manifestation features course is realized due to influence genetic factors. This study aimed investigate effect polymorphisms genes phase II detoxification system cardiovascular tone on severity in children. The included 163 children aged 5–18 years: 38 with severe asthma, 69 moderate 56 mild asthma. A molecular was conducted determine frequency gene propagation gen-gene interaction by GSTT1, GSTM1, GSTP1, ACE, eNOS, AT2R1,...
The paper deals with the influence of genetic polymorphisms on features folate metabolism and antioxidant protection in newborns critical conditions neonatal period. objective study was to examine changes metabolism, defense indicators their relationship polymorphism determine contribution genetically determined disorders development newborns. To perform work 45 infants were examined (gestational age 38-40 weeks) early period (the main group) 30 physiological comparison group). Examined...
The aim. To study the correlation of frequency distribution alleles, genotypes and their combinations for allelic variants ApaI, TagI, BsmI Vitamin D receptor gene (VDR) with vitamin levels stage fibrosis in children autoimmune hepatitis.Materials methods. 51 hepatitis were examined between 2016 2018. In all children, diagnosis was confirmed accordance International Guidelines liver diseases (European Association Study Liver (EASL) Clinical Practice Guidelines: Autoimmune Hepatitis, 2015)....
This article is to evaluate the efficacy of ranolazine in patients with ischemic heart disease (CHD), namely, dynamics symptoms angina and failure (CH). The functional level cells their during treatment were studied. After 1 month after treatment, positive clinical was noted (the number attacks decreased on average by half, duration – three times). A statistically significant decrease lipid peroxidation (LPO) observed malonic dialdehyde (MDA), total cholesterol, low density lipoprotein...
The purpose of this work was to determine the role genetic component in development combined course caries and gingivitis children.Materials methods: study involved 49 schoolchildren aged 7–15 years. Dental examination carried out according generally accepted method. children were divided carious process activity into two groups: 0–4 (compensated caries-comparison group) 5–8 (subcompensated – main group). Chronic generalized catarrhal (СGCG) detected these groups with frequency: 8 (29.62 %)...