A5009957313- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Lipoproteins and Cardiovascular Health
- Single-cell and spatial transcriptomics
- Macrophage Migration Inhibitory Factor
- Biomarkers in Disease Mechanisms
- Cardiac Fibrosis and Remodeling
- Fatty Acid Research and Health
- Genomics, phytochemicals, and oxidative stress
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Vector-borne infectious diseases
Lewis Gale Medical Center
2023
Derriford Hospital
2021-2023
Imperial College London
2014-2021
University of Bristol
2017
Vanderbilt University
2014
National Institutes of Health
2014
This study sought to compare the morbidity and mortality of redo aortic valve replacement (redo-AVR) versus valve-in-valve trans-catheter implantation (valve-in-valve TAVI) for patients with a failing bioprosthetic valve. A multicentre UK retrospective redo-AVR or TAVI referred intervention due degenerated bioprosthesis. Propensity score matching was performed confounding factors. From July 2005 April 2021, 911 underwent 411 TAVI. There were 125 pairs analysis after propensity matching. Mean...
Cytometric studies utilizing flow cytometry or multi-well culture plate fluorometry are often limited by a deficit in temporal resolution and lack of single cell consideration. Unfortunately, many cellular processes, including signaling, motility molecular transport, occur transiently over relatively short periods time at different magnitudes between cells. Here we demonstrate the multitrap nanophysiometer (MTNP), low-volume microfluidic platform housing an array traps, as effective tool...
Cardiac surgery can lead to post-operative end-organ complications secondary activation of systemic inflammatory response. We hypothesize that surgical trauma or cardiopulmonary bypass (CPB) may initiate response via release mitochondrial DNA (mtDNA) signaling Toll-like receptor 9 (TLR9) and interleukin-6 production (IL-6).The role TLR9 in cardiac was studied using a murine model sternotomy porcine CPB. mtDNA IL-6 were measured with without TLR9-antagonist treatment. To study...
Concomitant revascularization of coronary artery disease at the same time as treatment for aortic valvopathy favourably impacts survival. However, combined surgery may be associated with increased adverse outcomes compared to valve replacement (AVR) or bypass grafting in isolation.We retrospectively analyzed all patients who underwent AVR between February 1996 and March 2019 using data from National Adult Cardiac Surgery Audit. We used a generalized mixed-effects model assess effect number...
Rickettsial infection, known as Rocky Mountain spotted fever, is a challenging diagnosis early clinical manifestations are difficult to distinguish from viral illnesses. Symptoms at presentation depend on the organs involved, ranging skin rash evidence of vascular damage prerenal azotemia, respiratory failure, hepatic injury, or encephalitis. We report an unusual case otherwise healthy 83-year-old female whose serologies tested positive for Rickettsia rickettsii, which led cardiac...
Oxidized low-density lipoproteins play an important role in tissue pathology. In this study, we report a sensitive novel enzyme-linked immunosorbent assay for the detection of malondialdehyde-modified lipoprotein (MDA-LDL), key component oxidized LDL. The is capable measuring variable presence MDA-LDL within human plasma and serum. We demonstrate robust nature on samples stored over 20 months, as well high inter-operator reproducibility (r = 0.74, p < 0.0001). was detecting dynamic...
<h3>Background</h3> Atherosclerosis is a disease of global importance. It systemic chronic inflammatory with complex aetiology. LDL primarily oxidised in the subendothelial space, as plasma antioxidants protect circulating from oxidation. However, small amounts (oxLDL) have been detected plasma. Modified thought to circulate part an immune complex; these complexes may also include CRP, complement and IgM antibodies. This project aims develop capture ELISA measure oxLDL/CRP circulation, help...
Abstract Aim Coronary artery bypass graft surgery remains an effective treatment strategy for complex coronary disease.There paucity of data regarding the use bilateral radial conduits with wound, neurological and functional complications following surgical revascularisation. Method We reviewed outcomes retrospective analysis prospectively collected clinical from our database identified 30 patients who underwent CABG requiring harvest.Patient satisfaction was assessed using a quality life...