A5070239576- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- Biomarkers in Disease Mechanisms
- Head and Neck Anomalies
- Ultrasound and Hyperthermia Applications
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Nutrition and Health Studies
- Inflammatory mediators and NSAID effects
- Medical Imaging and Pathology Studies
- Bone Metabolism and Diseases
- Trace Elements in Health
- Bone health and treatments
- Diabetes Management and Research
- Metabolism and Genetic Disorders
- Sexual Differentiation and Disorders
- Kidney Stones and Urolithiasis Treatments
- Restraint-Related Deaths
- Kruppel-like factors research
- Glycosylation and Glycoproteins Research
- DNA Repair Mechanisms
- Teratomas and Epidermoid Cysts
Medical University of Białystok
2009-2025
University Clinical Hospital In Bialystok
2017
Diabetes Australia
2014-2016
Introduction: Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T (Treg) cells. Moreover, it has been established that deficiency Foxp3 gene in Treg cells suppresses their leading to autoimmune diseases especially thyroid diseases. The aim our study was estimate association three polymorphism FOXP3 with predisposition Graves' disease (GD) Hashimoto's thyroiditis (HT) children adolescents. Materials methods: performed group consisting 145 patients...
Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are common autoimmune endocrine disorders in children. Studies indicate that apart from environmental factors, genetic background significantly contributes to the development of these diseases. This study aimed assess prevalence selected single-nucleotide polymorphisms (SNPs) Il7R, CD226, CAPSL, CLEC16A genes children with thyroid We analyzed SNPs at locus rs3194051, rs6897932 IL7R, rs763361 rs1010601 rs725613 gene 56 HT patients, 124 GD...
Diabetes is undeniably a pandemic of the 21st century. Although type 1 diabetes mellitus (T1DM) only represents 10% all cases, it dominates pediatric population. The number T1DM cases accelerating, and Poland one countries with fastest increase in incidence. To evaluate epidemiological situation Podlaskie region, Poland. study included 777 patients (369 girls 408 boys) under 18. Incidence rates were calculated standardized to an age-matched population (general 2010). We showed upward trend...
<b><i>Background:</i></b> Ultrasound elastography is a noninvasive method of imaging based on the estimation mechanical properties tissue. Data in adults indicate that decreased flexibility comparison to surrounding healthy tissue characteristic malignancy (in most thyroid carcinomas, except for follicular carcinoma). The purpose our study was assess deformation nodules and evaluate usefulness predicting malignant adolescent patients....
Background: Immunological and hormonal disorders have undoubted influence on the development of atherosclerotic process. Autoimmune diseases accompanying type 1 diabetes (T1D) may additionally accelerate atherosclerosis progression increase risk cardiovascular events in future. The subclinical hypothyroidism system, particular, has recently aroused great interest. aim our study was to assess intima-media thickness (cIMT) common carotid arteries occurrence classical factors together with...
Autoimmune thyroid diseases (AITDs) which include Graves' disease (GD) and Hashimoto's thyroiditis (HT) as well type 1 diabetes (T1D) are common autoimmune disorders in children. Many genes involved the modulation of immune system their polymorphisms might predispose to development. According literature encoding IL2RA (alpha subunit Interleukin 2 receptor), IFIH1 (Interferon induced with helicase C domain 1) CTLA-4 (cytotoxic T cell antigen 4) be associated pathogenesis. The aim study was...
Graves' disease and Hashimoto's thyroiditis are associated with a disturbance of immune tolerance thyroid antigen molecules. The interleukin 2 receptor (IL2RA) is expressed by the regulatory T cells (Tregs) responsible for suppression. FAIM2 encodes molecule involved in apoptosis inhibition process. PADI4's expression activation T-cells, differentiation macrophages, which leads to increased inflammation. aim study was analyze polymorphisms IL-2RA (rs7093069), (rs7138803) PADI4 (rs1748033)...
The risk of malignancy in thyroid nodules correlates with the presence ultrasonographic features. In adults, ultrasound risk-classification systems have been proposed to indicate need for further invasive diagnosis. Furthermore, elastography has shown support differential diagnosis nodules. purpose our study was assess application American Thyroid Association (ATA), British (BTA) and strain management children adolescents from one center. Seventeen Bethesda III, IV, V VI were selected 165...
There are data indicating the coexistence of papillary thyroid carcinoma and autoimmune thyroiditis (AIT) in children. The aim study was elastographic evaluation nodules children adolescents with AIT nodular goiter relation to cytological and/or histopathological diagnosis. We examined 215 (57 boys 158 girls) 261 (143 non-AIT 118 AIT). All participants underwent a conventional ultrasound examination elastography followed by fine needle aspiration biopsy (FNAB). Abnormal Strain Ratio (SR ≥ 5)...
This study aims to asses the effects of estradiol vs. raloxifene on levels osteoprotegerin and soluble Receptor Activator Nuclear Factor kB Ligand (sRANKL) in Human Umbilical Vein Endothelial Cells (HUVEC) culture standard calcifying medium.Human were isolated from human umbilical vein by method. The supernatant concentrations (OPG) sRANKL (ELISA) determined after incubation with glicerophosphate, , raloxifene, glicerophoshate estradiol, glicerophosphate comparison control group at four...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
800x600 Heparin modulates function of vascular endothelium. We studied the effects unfractionated heparin (UFH) vs. enoxaparin sulodexide on levels and gene expression osteoprotegerin (OPG), Receptor Activator Nuclear Factor kB Ligand (RANKL) von Willebrand factor (vWF) in Human Umbilical Vein Endothelial Cells (HUVEC) culture. HUVEC were isolated from human umbilical vein by a standard method. The supernatant concentrations (ELISA) (Real Time-PCR) OPG, RANKL vWF determined after incubation...
Abstract Objectives Hypoparathyroidism is a rare disease in children that occurs as result of autoimmune destruction the parathyroid glands, defect gland development or secondary to physical disturbance. Typical symptoms hypoparathyroidism present hypocalcaemia and hyperphosphatemia due decreased hormone secretion may lead nerve muscles disturbances resulting clinical manifestation tetany, arrhythmias epilepsy. Currently, there no conventional replacement treatment for therapeutic approaches...
Background: Many epigenetic factors, including microRNAs, are involved in the process of changing gene expressions. Small non-coding RNA molecules, called miRNAs, responsible for regulating translation by silencing or degrading target mRNAs. It is acknowledged that many diseases, they may be novel diagnostic and prognostic biomarkers. Patients with autoimmune thyroid diseases more likely to develop nodules tissue, Hashimoto’s thyroiditis Graves’ disease predispose patients cancer. We...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)