A5001035549- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Sexual Differentiation and Disorders
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Birth, Development, and Health
- Diabetes Management and Research
- Acute Lymphoblastic Leukemia research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroendocrine Tumor Research Advances
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hematopoietic Stem Cell Transplantation
- Tea Polyphenols and Effects
- Digestive system and related health
- Nutrition and Health Studies
- Natural Compounds in Disease Treatment
- Peroxisome Proliferator-Activated Receptors
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Tendon Structure and Treatment
- Child and Adolescent Health
- 3D Printing in Biomedical Research
- Immunodeficiency and Autoimmune Disorders
Wroclaw Medical University
2016-2025
National Institute of Standards and Technology
2023
Université de Lorraine
2023
Altai State Medical University
2014
Center for Children
2012
Niepubliczna Wyższa Szkoła Medyczna
2006-2011
University of Pennsylvania
2011
Wroclaw University of Health and Sport Sciences
2006
The PC12 cell line is one of the most commonly used in neuroscience research, including studies on neurotoxicity, neuroprotection, neurosecretion, neuroinflammation, and synaptogenesis. Two types this are available ATCC collection: traditional cells grown suspension well-attached adherent phenotype. tend to aggregate adhere poorly non-coated surfaces. Therefore, it necessary modify surface culture vessels. This paper aims characterise use two distinct variants as well describe their...
The goal of this study was to the assess anti-cancer and antioxidant properties Ganoderma lucidum fruiting body, identify bioactive compounds found in their extracts. Significant antiproliferative activity observed against MCF-7, MCF-7/DX, LOVO, LOVO/DX, MDA-MB 231, SW 620, NHDF cell lines. With IC50 values 25.38 µg/mL 47.90 µg/mL, respectively, extract most effective 231 620 were identified using an ACQUITY UPLC-PDA-MS system. extracts contained 13 triterpenoids 28 polyphenols from...
Cancer resistance to chemotherapy is closely related tumor heterogeneity, i.e., the existence of distinct subpopulations cancer cells in a mass. An important role assigned stem (CSCs), small subset with high tumorigenic potential and capacity self-renewal differentiation. These properties CSCs are sustained by ability those maintain low intracellular reactive oxygen species (ROS) levels, via upregulation ROS scavenging systems. However, accumulation over critical threshold disturbs...
Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development various resistance mechanisms and presence stem cells (CSCs). Celastrol resveratrol are very promising phytochemicals for colon therapy, owing their pleiotropic activity that enables them interact biological targets. In present study, anticancer activities both compounds were investigated in metastatic (LoVo cells) stem-like...
Introduction: Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T (Treg) cells. Moreover, it has been established that deficiency Foxp3 gene in Treg cells suppresses their leading to autoimmune diseases especially thyroid diseases. The aim our study was estimate association three polymorphism FOXP3 with predisposition Graves' disease (GD) Hashimoto's thyroiditis (HT) children adolescents. Materials methods: performed group consisting 145 patients...
Autologous platelet-rich plasma (PRP) injection is a safe biological method used to treat various musculoskeletal diseases. By downregulation of inflammatory cytokines and stimulation synovial fibroblasts, PRP promising adjunctive treatment for patients with chronic autoimmune diseases such as rheumatoid arthritis. A major problem in comparing the results clinical trials this area considerable variability cytokine content PRP. We presented profile selected growth factors obtained samples...
Laser-induced periodic surface structures (LIPSS) are the sub-wavelength nanostructures generated by femtosecond laser. Implant topography and its nanostructural changes can be important for biomedical applications. In order to compare of different implants, appropriate mathematical physical descriptive methods should provided. The aim study was evaluate experimental LIPSS-based-Low Spatial Frequency LIPSS (LSFL) dental implant surfaces. Novel analysis, such as Fractal Dimension Analysis...
Colorectal cancers are one of the leading worldwide and known for their high potential metastasis resistance to therapy. The aim this study was investigate effect various combination therapies irinotecan with melatonin, wogonin, celastrol on drug-sensitive colon cancer cells (LOVO cell line) doxorubicin-resistant stem-like (LOVO/DX subline). Melatonin is a hormone synthesized in pineal gland responsible circadian rhythm. Wogonin natural compounds previously used traditional Chinese medicine....
Background: Colorectal cancer is one of the leading and most lethal neoplasms. Standard chemotherapy ineffective, especially in metastatic cancer, does not target stem cells. A promising approach to improve treatment combination therapy standard cytostatic drugs with natural compounds. Several plant-derived compounds have been proven possess anticancer properties, including induction apoptosis inhibition invasion. This study was focused on investigating vitro camptothecin (CPT) celastrol...
This article presents framework guidelines for the care of adolescent transgender (T) and non-binary (NB) individuals experiencing gender dysphoria (GD) and/or incongruence (GI). Developed by a multidisciplinary expert panel, these aim to address complex medical, psychological, social needs this diverse population. The document emphasises importance individualised, affirmative that respects autonomy, identity, rights adolescents. It outlines best practices psychiatric, sexological...
Background. Children with central precocious puberty (CPP) present various somatic and psychological abnormalities.Objectives. The aim of the study was to evaluate growth changes in girls treated GnRH analog therapy analyze factors affecting auxological response this treatment.Material Methods. group consisted 40 onset aged 6.0 ± 1.9 years (mean, SD), 3.75 mg decapeptyl depot intramuscularly every 28 days. treatment initiated at age 7.5 2.2 continued for 3.3 2.3 years, until 11.4 0.9 years....
The results of studies assessing whether patients with Down syndrome have increased risk coeliac disease are contradictory. prevalence in is estimated at a wide range between 1% to as much 18.6%.To assess Poland.The study enrolled 301 from six centres Poland (Wroclaw, Sandomierz, Rzeszow, Grudziadz, Katowice, and Bydgoszcz). We measured the concentration anti-tissue transglutaminase IgA antibodies anti-deamidated gliadin peptide IgG all patients. Patients abnormal positive (> 10 U/ml) or...
Background. MicroRNAs are endogenous, small noncoding RNA molecules that play a pivotal role in the regulation of gene expression. involved many biological processes such as proliferation, cell differentiation, neovascularization, and apoptosis. Studies on microRNA expression may contribute to better understanding pathomechanism chronic inflammatory demyelinating polyneuropathy (CIDP) consequently enable development new therapeutic measures using antisense miRNAs (antagomirs). In this study,...
Autologous platelet-rich plasma (PRP) injection is an alternative treatment option for patients with lateral elbow tendinopathy. The supposed to accelerate tissue regeneration by providing high concentrations of growth factors derived from platelets. aim the study was assess relationship between content biologically active compounds in PRP and clinical effect treatment. Thirty tendinopathy treated a single injection, were evaluated. pain intensity (measured visual analogue scale (VAS)),...