A5074137476- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Genetics, Aging, and Longevity in Model Organisms
- Inorganic and Organometallic Chemistry
- Cancer therapeutics and mechanisms
- Advanced Synthetic Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Fluorine in Organic Chemistry
- Carbohydrate Chemistry and Synthesis
- Sirtuins and Resveratrol in Medicine
- GABA and Rice Research
- Chemical Reaction Mechanisms
Osaka University
2015-2019
Suita Municipal Hospital
2017-2018
The development of a novel chemoselective functionalization can diversify the strategy for synthesizing target molecules. perfect chemoselectivity between aromatic and aliphatic aldehydes is difficult to achieve by previous methods. aldehyde-selective nucleophilic addition in presence was newly accomplished. Namely, using arenes allyl silanes proceeded trialkylsilyl triflate 2,2′-bipyridyl, while completely remained unchanged. reactive pyridinium-type salt intermediate derived from an...
Unprecedented chemoselectivity between aromatic and aliphatic aldehydes has been achieved in the Mukaiyama aldol reaction using aldehyde-derived silyl enol ethers.
Highly discriminative transformation of α,β-unsaturated esters in the presence enones using two types phosphonium salts, and their application to synthesis oxacyclic compounds six steps one pot have been achieved.
Acetals are the most useful protecting groups for carbonyl functional groups. In addition to role of protection, they can also be used as synthons functions. Previously, we developed a chemoselective deprotection and nucleophilic substitution acetals from aldehydes in presence ketals. This article describes highly discriminative transformations bearing different patterns, types acetals, well mixed acetals. These reactions achieve that cannot attained by conventional methods, their results...
The intermediates formed during the Beckmann fragmentation of α-alkoxy and α-alkoxy-α-alkyl oxime acetates have been successfully trapped as phosphonium salts, which were subsequently reacted with a variety Grignard reagents to give corresponding substituted products in good yields. Notably, this reaction proceeded smoothly even from acetates.
Abstract α,β‐Unsaturated carbonyl groups are found in many natural products and functional molecules. The reactivity of nucleophiles towards α,β‐unsaturated carbonyls, such as β‐monosubstituted disubstituted ketones (enones) ynones, is similar. Therefore, the development a method to selectively convert carbonyls desirable. In this study, selective one‐pot reductions allylations β‐disubstituted enones or ynones were accomplished presence using an situ protection methodology. β‐Monosubstituted...
Aromatic methoxymethyl (MOM) ethers behave differently from aliphatic MOM upon treatment with trialkylsilyl triflate (R3SiOTf) and 2,2'-bipyridyl. The aromatic are first converted to silyl subsequently deprotected by hydrolysis give the mother alcohols when R3SiOTf used is trimethylsilyl (TMSOTf). Conversely, direct conversion of triethylsilyl (TES) possible (TESOTf).
Abstract Various α‐alkoxy oximes are converted with collidine to form a collidinium salt intermediate, which reacts cuprates (II) or (V) give the corresponding nitriles.
The synthesis of new N1,N8-diacetylspermidine (DiAcSpd) analogues having a linker with desired functional groups in the methylene skeleton, which have been designed by theoretical calculations, is described. We also achieved preparation DiAcSpd supported on solid-phase resins, potential to be used for evolution ligands exponential enrichment (SELEX).