Background Allergic rhinitis (AR) is a common disease characterized by chronic inflammation of the nasal mucosa, but we have not fully understood mechanism responsible for development AR. MicroRNAs (miRNAs) are short endogenous noncoding RNAs regulating protein translation through known as RNA interference. To understand molecular mechanisms miRNA involved in pathogenesis AR, expressed miRNAs AR were investigated genomewide microarray analysis. Methods Mammalian microarrays containing whole...

Different types of medications are currently used in vestibular migraine (VM) prophylaxis, although recommendations for use generally based on expert opinion rather than solid data from randomized trials. We evaluated the efficacy and safety venlafaxine, flunarizine, valproic acid a comparison trial VM prophylaxis. Subjects were randomly allocated to one three groups (venlafaxine group, flunarizine group). To assess treatment vertigo symptoms, following parameters assessed at baseline 3...

We aimed to evaluate the impact of intracranial pressure on prognosis cerebrospinal fluid (CSF) rhinorrhea repair surgeries, identify critical diagnostic considerations for CSF associated with hypertension, and provide insights into developing effective, individualized treatment strategies these patients. analyzed clinical data 16 confirmed 5 suspected cases hypertension treated at our hospital from 2015 2021. documented trends in before after surgical intervention, assessed manifestations,...

Background: Few studies focused on the prognosis of sudden sensorineural hearing loss (ISSHL) aged people.Objectives: The aim this study is to analyze characteristics, treatment, and prognostic factors ISSHL in people.Material methods: A total 278 patients diagnosed people from 2014 2019 were retrospectively analyzed. Univariates analyzed by univariate multivariate logistic analysis.Results: Among 13 univariates, patients’ age was younger overall recovery group ORG (p = .018), while onset...

This study aimed to investigate the value of surgery revised uvulopalatopharyngoplasty (UPPP) on ambulatory blood pressure (BP) in obstructive sleep apnea/hypopnea syndrome (OSAHS) patients with hypertension and oropharyngeal obstruction. A retrospective cohort was performed 29 OSAHS hypertension, who received treatment UPPP surgery. After 1 month, Apnea-hypopna index (AHI) body mass (BMI) significantly decreased (P < 0.05), mini SpO2 mean increased than before 0. 05), but heart rate showed...

Purpose: This study aimed to explore the ability of fusion images non-echo planar diffusion-weighted magnetic resonance imaging (non-EPI-DWI MRI) and computed tomography (CT) accurately locate cholesteatoma plan surgical approach. Methods: In first part, 41 patients were included. Their CT non-EPI DWMRI fused. The scope in image was compared with that video evaluate capability cholesteatoma. A total 229 included second they divided into 2 groups. We chose approach for group group, accuracy...

Abstract Ginkgo biloba extract (GBE) has been widely used to treat cardiovascular and cerebrovascular disorders. Hyperhomocysteinemia (Hhcy) is associated with the risk of atherosclerosis restenosis after angioplasty. The objective this study was investigate whether GBE could attenuate Hhcy‐induced intimal thickening balloon injury in rabbit abdominal aorta. It observed that decrease neointima area (NA) ratio media (NA/MA), down‐regulate mRNA expression matrix metalloproteinase‐9 (MMP‐9)...

Slug is associated with the radioresistance of nasopharyngeal carcinoma (NPC) and main current approach treatment for NPC radiotherapy. Hence, aim study was to determine effect silencing on radiosensitivity cells. Lentiviral‑mediated transfection RNA interference (RNAi) in cell line C666‑1 performed vitro. Following inhibition, its expression detected using western blotting. A clonogenic survival assay flow cytometry were then evaluate survival, cycle distribution apoptosis cells following...

The vestibule of the inner ear is susceptible to certain chemotherapeutic agents in clinical practice. Therefore, it great significance discover molecular pathways and targets that can protect from drugs. Notch signaling pathway closely related hair cell regeneration ear. However, role drug-induced vestibular injury still remains unclear. aim this study was first evaluate chemotherapy-induced injury. Cisplatin-induced mice evaluated by swimming test. Changes cells expression levels Notch1,...

Pseudo-benign paroxysmal positional vertigo (pseudo-BPPV) is a specific type of vestibular migraine disguised as benign vertigo, which characterized by recurrent different types and atypical with features. It easy to be misdiagnosed BPPV at the first visit, means that ideal therapeutic effects are not achieved. Twenty-five cases pseudo-BPPV frequent changing were retrospected following key features help identify disease: migrainous accompanying symptoms or history, mild indistinctive...

Chorda tympani schwannoma is a very rare tumor, with only 12 reported cases in the English literature. There are few reports on diagnosis of chorda schwannoma, and it easily misdiagnosed. At present, surgery recognized as treatment for schwannoma. We describe clinical course patient presenting treated surgical resection using transcanal endoscopic approach, results after this were satisfactory. Therefore, we accordingly advocate minimally invasive method to maximize intraoperative...

Auricular pseudocyst is a benign cystic lesion in cartilages of the auricle. Different methods are currently used to manage this disease. In these methods, simple aspiration combined with pressure dressing, local steroid injection and surgery most prevalent therapies.To find best clinical path for treatment auricular pseudocyst.Eighty-four subjects were randomly allocated into three equal groups (Group A: suction dressing; Group B: injection; and, C: surgery). Two otolaryngologists assessed...

Nocardia farcinica usually infects people with impaired immune status and manifests in the lungs. Otomastoiditis caused by infection is extremely rare, only 4 cases reported to date. This report describes a case of otomastoid N. an immunocompetent patient. The was 10-month-old infant who presented approximately 3-month history right ear discharge for which treatment various antibiotics had not resulted significant improvement. Multiple cultures secretions pathologic examination failed...

The swift global spread of coronavirus disease 2019 (COVID-19), a respiratory ailment primarily marked by pulmonary symptoms, has been linked to the involvement various organs, including intestines, kidneys, throat, and ears. Otitis media with effusion (OME), often succeeding an upper tract infection, mirrors its incidence. As infectious disease, it prompts query whether COVID-19 pandemic spurred uptick in OME virus persists middle ear (MEE) for extended period. To gauge incidence population...