A5062896743- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Liver Diseases and Immunity
- Bone and Joint Diseases
- Mesenchymal stem cell research
- Autoimmune and Inflammatory Disorders Research
- Liver Disease Diagnosis and Treatment
- Wound Healing and Treatments
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal pain and rehabilitation
- Mobile Health and mHealth Applications
- Spine and Intervertebral Disc Pathology
- Hepatitis C virus research
- Nerve injury and regeneration
- Maternal and Perinatal Health Interventions
- Advanced Sensor and Energy Harvesting Materials
- Bone Metabolism and Diseases
- Angiogenesis and VEGF in Cancer
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Army Medical University
2009-2024
Ministry of Education of the People's Republic of China
2023
Heilongjiang University
2018
Huazhong University of Science and Technology
2006
National University Hospital
1989-1992
Indiana University School of Medicine
1987
Indiana University – Purdue University Indianapolis
1987
China has a large population; however, medical resources are unevenly distributed and extremely limited, more services needed. With the development ever-increasing popularity of mobile internet communication, created mode health (mHealth) care to resolve this problem.The aim study was (1) describe problems associated with China's practice, (2) explore need for feasibility internet-based in China, (3) analyze functionality offered by platforms management chronic diseases.Data search performed...
Although strong underwater bioadhesion is important for many biomedical applications, designing adhesives to perform in the presence of body fluids proves be a challenge. To address this, we propose an and situ applicable hydrophobic adhesive (UIHA) composed polydimethylsiloxane, entangled macromolecular silicone fluid, reactive silane. The fluid displaced boundary water, formed gel, bonded tissues, achieved exceptional adhesion strength. Its lap shear on porcine skin was significantly...
ABSTRACT Objective The association of long‐term hyperuricemia with liver function remains less well understood. This prospective cohort study aimed to investigate the relationship between and as other metabolic cardiovascular parameters. Methods We enrolled 375 participants 599 normouricemic controls. Participants were followed up for 3 years, data on indicators, including alanine aminotransferase (ALT), aspartate (AST), ultrasonography collected. Additionally, we assessed parameters, such...
Angiogenesis is a major obstacle for wound healing in patients with diabetic foot wounds. Mesenchymal stem cells (MSCs) have an important function repair, and neurotrophin-3 (NT-3) can promote nerve regeneration angiogenesis. We investigated the effect of NT-3 on accelerating by improving human bone marrow MSC (hMSC) activation. In vitro, significantly promoted VEGF, NGF, BDNF secretion hMSCs. improved activation hMSC conditioned medium, umbilical vein endothelial cell (HUVEC) proliferation...
The application of tissue-engineered blood vessels (TEBVs) is the main developmental direction vascular replacement therapy. Due to few and/or dysfunctional endothelial progenitor cells (EPCs), it difficult successfully construct EPC capture TEBVs in diabetes. RNA has a potential cell protection and diabetes treatment, but poor specificity low efficiency transfection vivo limit RNA. On basis an acellular matrix, we propose aptamer–siRNA chimera-modified TEBV that can maintain satisfactory...
Abstract Background Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, the correlation between efficacy of TNF-α inhibitor changes in is unclear. Methods A total 40 cells were tested flow cytometry, results 105 healthy control (HC) subjects, 177 active-stage AS patients, 23 cases before after 12 weeks therapy (Anbainuo) analyzed. Results Compared HC group, proportion cells, such as naïve central memory CD4+T increased ( P < 0.0001), but...
Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as hematopoietic stem niche secretes cardioprotective factors MI, it is unclear whether could be used human pluripotent (hiPSC) cultivation provide proper microenvironment grafts against the environment. Herein, we developed splenic extracellular matrix derived thermoresponsive hydrogel...
Small-diameter tissue-engineered vascular grafts (sdTEVGs) are essential materials used in bypass or replacement surgery for cardiovascular diseases; however, their application efficacy is limited because of patency rates, especially under hyperlipidemia, which also clinically observed patients with diseases. In such cases, improving sdTEVG challenging cholesterol crystals easily cause thrombosis and impede endothelialization. Herein, the development a biomimetic antithrombotic incorporating...
Cross-linking agents are frequently used to restore corneal properties after decellularization, and it is especially important select an appropriate method avoid excessive cross-linking. In addition, how promote wound healing improve scar formation require further investigation. To ensure the safety efficacy of animal-derived products, we designed bioartificial corneas (BACs) according criteria for Class III medical devices. Our BACs do not cross-linking increase mechanical strength via...
Abstract The aim of the study was to investigate and compare clinical manifestations between HLA‐B27 + − ankylosing spondylitis ( AS ) patients in order obtain knowledge impact status on , inform treatment. A nationwide epidemiological investigation performed from November 2008 October 2010. demographic data characteristics, were collected using questionnaires laboratory assay, respectively. total 2144 (78.5% males 78.4% patients) participated this study. percentages males, with family...
Abstract Small‐diameter (<6 mm) tissue–engineered blood vessels (TEBVs) have a low patency rate due to chronic inflammation mediated intimal hyperplasia. Functional coating with drug release is promising solution, but preventing the released from being rushed away by flow remains great challenge. A single‐walled carboxylic acid functionalized carbon nanotube (C‐SWCNT) used build an irregular mesh for TEBV coating. However, interaction between and cells still insufficient flow. Thus,...
Human leukocyte antigen ( HLA )‐ B27 is closely associated with ankylosing spondylitis AS ). However, the exact correlation between HLA‐B27 subtypes and manifestations remains unknown. This study aimed to investigate polymorphism clinical features of . included 846 patients 959 healthy controls. Direct sequencing was used identify genotype. Clinical parameters, including age, age onset, family history, low back pain, peripheral arthritis, hip joint involvement, dactylitis, uveitis, sex...
ABSTRACT Objective To assess the reliability of intrauterine pressure measurements in labour with transducer tipped catheters. Design Prospective clinical study. Setting Delivery ward, National University Hospital, Singapore. Subjects 20 women admitted early were randomly allocated to two groups. Interventions Women first group had catheters that been tied together introduced transcervically into same amniotic fluid pocket. The second different directions so each catheter tip was a pocket...
Background: Anti-IL-17A therapy is generally effectively applied in patients with Ankylosing Spondylitis (AS) to achieve and maintain remission. However, the influence of anti-IL-17A on composition immune system not apparent. Our prospective study was explore changes imbalance regarding T cell, B cell natural killer (NK) subsets after secukinumab treatment AS patients. Methods: Immune distribution 43 treated for 12 weeks 47 healthy controls (HC) were evaluated. Flow cytometry using...
Electrical stimulation is an effective strategy for facilitating wound healing. However, it hindered by unwieldy electrical systems. In this study, a light-powered dressing based on long-lived photoacid generator (PAG)-doped polyaniline composites used, which can generate photocurrent under visible light irradiation to interact with the endogenous electric field and facilitate skin growth. Light-controlled proton binding dissociation result in oxidation reduction of backbone, inducing charge...
Stem cell-derived blood vessel organoids are embedded in extracellular matrices to stimulate sprouting. Although vascular 3D collagen I-Matrigel gels currently available, they primarily capillaries composed of endothelial cells (ECs), pericytes, and mesenchymal stem-like cells, which necessitate mature arteriole differentiation for neovascularization. In this context, the hypothesis that matrix viscoelasticity regulates development is investigated cultures by encapsulating within...
Great challenges in transplantation of mesenchymal stem cells (MSCs) for treating ischemic diabetic ulcers (IDUs) are to find a suitable carrier and create beneficial microenvironment. Brain-derived neurotrophic factor (BDNF), member neurotrophin family, is considered angiogenic neuroprotective. Given that IDUs caused by vascular disease peripheral neuropathy, we used BDNF as stimulant, intended explore the role new biomaterials complex with MSCs wound healing. promoted proliferation...