A5066353382- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Pneumonia and Respiratory Infections
- Parvovirus B19 Infection Studies
- Pulmonary Hypertension Research and Treatments
- Hedgehog Signaling Pathway Studies
- Pituitary Gland Disorders and Treatments
- Blood disorders and treatments
- Bacterial Infections and Vaccines
- Neonatal Health and Biochemistry
- Neonatal Respiratory Health Research
- Williams Syndrome Research
- Vascular Malformations and Hemangiomas
- Blood Coagulation and Thrombosis Mechanisms
- Genetic and Kidney Cyst Diseases
- Tracheal and airway disorders
- Autoimmune and Inflammatory Disorders Research
- Atrial Fibrillation Management and Outcomes
- Vasculitis and related conditions
- Cystic Fibrosis Research Advances
- Genetic Syndromes and Imprinting
- Dermatological and COVID-19 studies
Hôpital Sahloul
2010-2024
GTx (United States)
2023
Hôpital Farhat Hached
2020
University of Sousse
2018
Hopital Universitaire Hedi Chaker
2017
Covance (United Kingdom)
2015
Background Ellis-van Creveld syndrome (EvC) is a recessive disorder characterised by acromesomelic limb shortening, postaxial polydactyly, nail-teeth dysplasia and congenital cardiac defects, primarily caused pathogenic variants in EVC or EVC2 . Weyers acrofacial dysostosis (WAD) an ultra-rare dominant condition allelic to EvC. The present work aimed enhance current knowledge on the clinical manifestations of EvC WAD broaden their mutational spectrum. Methods We conducted molecular studies...
Abstract Background Patients with Down syndrome are at a higher risk of developing autoimmune disorders such as thyroiditis, diabetes, and celiac disease compared the general population. Although some diseases well known to be associated syndrome, others idiopathic pulmonary hemosiderosis ischemic stroke due protein C deficiency remain rare. Case presentation We report case 2.5-year-old Tunisian girl hypothyroiditis admitted dyspnea, anemia, hemiplegia. Chest X-ray showed diffuse alveolar...
Autoimmune hemolytic anemia is rare in children. First-line therapies for this disease consist of corticosteroids and intravenously administered immunoglobulin that are effective most patients. However, a small proportion cases (5 to 10%) refractory these may represent medical emergency, especially when hemolysis due warm M. Recently, reports the use rituximab adult autoimmune diseases have shown promising results. In children, there few studies on treatment anemia, its long-term efficacy...
Aim: To establish a preliminary national report on clinical and genetic features of cystic fibrosis (CF) in Tunisian children as first measure for better health care organization.
 Methods: All with CF diagnosed by positive sweat tests between 1996 2015 children’s departments university hospitals were included. Data was recorded at diagnosis during the follow-up from patients’ medical records.
 Results: In 12 departments, 123 collected. The median age 5 months diag- nosis delay 3...
Abstract Background Children affected by Coronavirus disease 2019 (COVID-19) showed various manifestations. Some of them were severe cases presenting with multi-system inflammatory syndrome (MIS-C) causing multiple organ dysfunction. Case presentation We report the case a 12-year-old girl recent COVID-19 infection who presented persistent fever, abdominal pain and other symptoms that meet definition MIS-C. She had lymphopenia high level markers. was admitted to pediatric intensive care unit...
Kawasaki disease (KD) is an acute febrile systemic vasculitis occurring predominantly in young children less than 5 years of age. Although imperfectly known, the aetiopathogenesis KD would be secondary to immunological abnormalities that could constitute a favourable terrain for neoplasms. We report on case 2-year-old girl who presented clinical manifestations compatible with complicated by coronary aneurysm. Aetiopathological investigations revealed M. pneumoniae infection as specific IgM...
Infective endocarditis is a rare condition in childhood, and there limited data on this disease Tunisia.
Aims & Objectives: Burns represent a global public health problem affecting both adults and children. Each year, approximately 11 million people suffer from burns, with higher prevalence among children, especially those under 5 years of age. Aim: To describe the epidemiological clinical features, as well complications, severe burns in children short term. Methods: It is retrospective cross-sectional analytical study conducted on who were hospitalized Pediatrics Department Sahloul Hospital...
Aims & Objectives: Central venous catheters (CVC) represent devices commonly used in pediatric intensive care units. However, they are associated to multiple potentially severe complications. Aim: evaluate indications and complications of CVC children hospitalized our unit. Methods: It is a prospective, analytical study including all inserted the unit department Sahloul hospital during 26 months. Results: Our included 85 CVCs for 70 children. Most them were indicated parenteral nutrition...
Aims & Objectives: Therapeutic plasma exchange (TPE) is a technique of extracorporeal blood purification used in wide range diseases. While there are many studies on TPE adult patients, few have focused its use the pediatric population. Aim: To analyse clinical indications, outcomes, and complications intensive care unit (PICU). Methods: This retrospective study conducted PICU Sahloul hospital. Our included all patients who underwent were hospitalized between 2000 2023. Results: Eight our...
<sec><title>Introduction</title><p>Williams-Beuren syndrome (WBS) is a rare genetic disorder characterized by congenital heart defects, dysmorphic features, intellectual delay, and distinctive social behavioral profile. This highly recurrent homogeneous phenotype has been curiously reported to be associated with autism spectrum disorders (ASD). Both environmental origins have implicated. study aimed describe Tunisian patients WBS ASD explore the underlying...
In this study, we describe the case of a 5-year-old boy who presumably presented with Loeys-Dietz syndrome. A huge aneurysm ascending aorta and aortic arch extended beyond left subclavian artery was accompanied by slight narrowing isthmus.
<h3>Introduction</h3> Tuberculosis (TBC) continues to cause an unacceptably high toll of disease and death among children worldwide, particularly in the developing countries. <h3>Objective</h3> Study epidemiological clinical aspects TBC Tunisian clarify its treatment. <h3>Population methods</h3> A descriptive study was carried out, included all cases diagnosed Sahloul paediatric unit hospital between 2004 2013. Epidemiological, microbiological data were recorded. Therapeutic evolutionary...
Pseudotumoral cerebellitis in childhood is an uncommon presentation of mimicking a brain tumor.It often follows inflammatory or infectious event, particularly due to varicella virus.Patients could have wide clinical spectrum on presentation.Some patients may be asymptomatic present at most with mild cerebellar signs, whereas others suffer severe forms brainstem involvement and intracranial hypertension tumor warranting surgical intervention.Imaging techniques especially multimodal magnetic...