A5009902751- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Testicular diseases and treatments
- CAR-T cell therapy research
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Reproductive System and Pregnancy
Masaryk Memorial Cancer Institute
2015-2024
Masaryk University
2014-2024
Weatherford College
2021
Miroslav Krleža Institute of Lexicography
2021
Národný Onkologický Ústav
2009-2020
Polytechnic Lavoslav Ružička Vukovar
2013
University Hospital in Motol
2012
Sanofi (France)
2012
University of Turin
2012
European Hospital
2012
Purpose Treatment for metastatic colorectal cancer (mCRC) commonly involves a fluoropyrimidine-based chemotherapy regimen such as infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) or oxaliplatin, often combined with bevacizumab an epidermal growth factor receptor monoclonal antibody. We studied the effect of adding novel antiangiogenic agent aflibercept (also known ziv-aflibercept in United States) to FOLFIRI patients mCRC previously treated including who received prior...
Abstract Background There is no standard serum biomarker used for diagnosis or early detection of recurrence renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, have been recently described as powerful circulating biomarkers a wide range solid cancers. Our aim was to identify miRNA signature that can distinguish the RCC patients matched healthy controls validate identified miRNAs potential RCC. Methods In screening phase study, 15 12 were...
PurposeThe antiangiogenic agent aflibercept (ziv-aflibercept in the United States) combination with 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) significantly improved survival a phase III study of patients metastatic colorectal cancer (mCRC) previously treated an oxaliplatin-based regimen. In present analysis, outcomes were evaluated prespecified subgroups to assess consistency treatment effect.MethodsPatients randomised receive FOLFIRI plus or placebo every 2 weeks until disease...
Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain tumor; patients with GBM often have a very poor prognosis and differing responses to treatment. Therefore, it important find new biomarkers that can predict clinical outcomes help in treatment decisions. MicroRNAs are small, non-coding RNAs function as post-transcriptional regulators of gene expression play key role pathogenesis GBM. In group 38 GBM, we analyzed eight microRNAs (miR-21, miR-128a, miR-181c,...
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies showed altered expression levels of several microRNAs in glioblastomas. In this study, we examined the selected 22 primary glioblastomas and six specimens adult brain tissue by real-time PCR method. addition, methylation status MGMT promoter methylation-specific PCR, as has been shown to be a predictive marker was not correlated with response concomitant chemoradiotherapy temozolomide (RT/TMZ). MiR-221...
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma. We examined the selected 38 samples conventional carcinoma (RCC) and 10 non-tumoral parenchyma using TaqMan real-time PCR method. The miRNA-155 (p < 0.0001), miRNA-210 miRNA-106a 0.0001) miRNA-106b were significantly over-expressed tumor tissue, whereas miRNA-141 miRNA-200c decreased RCC samples. There no significant differences...
The accurate identification of glioblastoma progression remains an unmet clinical need. aim this prospective single-institutional study is to determine and validate thresholds for the main metabolite concentrations obtained by MR spectroscopy (MRS) values apparent diffusion coefficient (ADC) enable distinguishing tumor recurrence from pseudoprogression. Thirty-nine patients after standard treatment a underwent advanced imaging MRS ADC at time suspected - median was 6.7 months. highest...
Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney. One important unmet medical needs in RCC prognostic biomarker enabling identification patients at high risk relapse after nephrectomy. MicroRNAs (miRNAs) constitute a robust regulatory network with posttranscriptional efficiency for almost one-half human coding genes, including oncogenes and tumor suppressors. To identify potential miRNAs, we analyzed expression profiles tumors different groups patients. Seventy-seven...
The aim of this retrospective study is to provide real-world evidence in glioblastoma treatment and compare overall survival after Stupp's regimen today a decade ago. A current consecutive cohort histologically confirmed irradiated from 1/2014 12/2017 our cancer center was compared with an already published historical control patients treated 1/2003-12/2009. total new 155 analyzed, median age 60.9 years, 61% men, 58 (37%) underwent gross tumor resection. indicated 90 (58%), 65 (42%)...
The role of nonclassical human leukocyte antigens G and E (HLA-G HLA-E) was originally thought to be restricted the protection fetus from a maternal allorecognition. Now it is known that HLA-G HLA-E exert multiple immunoregulatory functions. A prognostic significance expression by neoplastic cells in glioblastoma not well characterized. In this study, we evaluated 39 cases glioblastoma. We found production HLA majority cases. There an unexpected positive correlation between length survival....
Renal cell carcinoma (RCC) is the most common neoplasm of adult kidney accounting for about 3 % malignancies. MicroRNAs (miRNAs) are a class naturally occurring, short non-coding RNAs that regulate gene expression at post-transcriptional level. We determined global miRNA profiles RCC and parallel renal parenchyma tissues by using quantitative reverse transcriptase-polymerase chain reaction-based TaqMan low-density arrays. Afterward, we validated difference in miR-210 levels on larger group...
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor. Despite radical surgery and radiotherapy supported by chemotherapy, disease still remains incurable with an extremely low median survival rate 12-15 months from time initial diagnosis. The main cause treatment failure considered to be presence cells that are resistant treatment. MicroRNAs (miRNAs) as regulators gene expression involved in tumor pathogenesis, including GBM. MiR-338 a brain-specific miRNA which has been...
Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) contribute to its resistance adjuvant treatment. MicroRNAs (miRNAs) small, non-coding RNAs controlling gene expression at post-transcriptional level, which known be important regulators features. Moreover, miRNAs have been previously proved promising diagnostic biomarkers in several cancers including GBM. Using global analysis 10 paired in-vitro as well in-vivo characterized primary...
Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it an immunogenic tumor - able stimulate antitumor responses. A prognostic significance of HLA-G expression neoplastic cells in RCC not well characterized; HLA-E at all. In our study, we evaluated and specific mRNA transcripts produced 38 cases 10 samples normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. We...
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and histopathological examination not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators gene expression were repeatedly proved to play important roles in pathogenesis GBM. In our study, we performed global miRNA profiling 58 glioblastoma tissue samples obtained during surgical...
Abstract Background Immunotherapy and targeted therapy are currently two alternative backbones in the of BRAF‐mutated malignant melanoma. However, predictive biomarkers that would help with treatment selection lacking. Methods This retrospective study investigated outcomes anti‐programmed death receptor‐1 monotherapy first‐line setting patients metastatic melanoma, focusing on clinical laboratory parameters associated outcome. Results Data from 174 were analysed. The median progression‐free...