A5033784811- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Education, Psychology, and Social Research
- Management of metastatic bone disease
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging Techniques and Applications
- Reproductive System and Pregnancy
- Head and Neck Surgical Oncology
- Advanced Neuroimaging Techniques and Applications
- Abdominal Surgery and Complications
Masaryk University
2013-2024
University Hospital Brno
2015-2024
Masaryk Memorial Cancer Institute
2024
Povodí Moravy
2020
Ocní klinika
2020
University of Central Florida
2017
Florida College
2017
Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain tumor; patients with GBM often have a very poor prognosis and differing responses to treatment. Therefore, it important find new biomarkers that can predict clinical outcomes help in treatment decisions. MicroRNAs are small, non-coding RNAs function as post-transcriptional regulators of gene expression play key role pathogenesis GBM. In group 38 GBM, we analyzed eight microRNAs (miR-21, miR-128a, miR-181c,...
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies showed altered expression levels of several microRNAs in glioblastomas. In this study, we examined the selected 22 primary glioblastomas and six specimens adult brain tissue by real-time PCR method. addition, methylation status MGMT promoter methylation-specific PCR, as has been shown to be a predictive marker was not correlated with response concomitant chemoradiotherapy temozolomide (RT/TMZ). MiR-221...
The aim of this retrospective study is to provide real-world evidence in glioblastoma treatment and compare overall survival after Stupp's regimen today a decade ago. A current consecutive cohort histologically confirmed irradiated from 1/2014 12/2017 our cancer center was compared with an already published historical control patients treated 1/2003-12/2009. total new 155 analyzed, median age 60.9 years, 61% men, 58 (37%) underwent gross tumor resection. indicated 90 (58%), 65 (42%)...
Central nervous system (CNS) malignancies include primary tumors that originate within the CNS as well secondary develop a result of metastatic spread. Circulating microRNAs (miRNAs) were found in almost all human body fluids including cerebrospinal fluid (CSF), and they seem to be highly stable resistant even extreme conditions. The overall aim our study was identify specific CSF miRNA patterns could differentiate among brain tumors. These new biomarkers potentially aid borderline or...
The role of nonclassical human leukocyte antigens G and E (HLA-G HLA-E) was originally thought to be restricted the protection fetus from a maternal allorecognition. Now it is known that HLA-G HLA-E exert multiple immunoregulatory functions. A prognostic significance expression by neoplastic cells in glioblastoma not well characterized. In this study, we evaluated 39 cases glioblastoma. We found production HLA majority cases. There an unexpected positive correlation between length survival....
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor. Despite radical surgery and radiotherapy supported by chemotherapy, disease still remains incurable with an extremely low median survival rate 12-15 months from time initial diagnosis. The main cause treatment failure considered to be presence cells that are resistant treatment. MicroRNAs (miRNAs) as regulators gene expression involved in tumor pathogenesis, including GBM. MiR-338 a brain-specific miRNA which has been...
Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) contribute to its resistance adjuvant treatment. MicroRNAs (miRNAs) small, non-coding RNAs controlling gene expression at post-transcriptional level, which known be important regulators features. Moreover, miRNAs have been previously proved promising diagnostic biomarkers in several cancers including GBM. Using global analysis 10 paired in-vitro as well in-vivo characterized primary...
Glioblastoma (GBM) is one of the deadliest human cancers responding very poorly to therapy. Although central nervous system has been traditionally considered an immunologically privileged site with enhanced immune response, GBM appears benefit from this immunosuppressive milieu. Immunomodulatory molecules play important role in tumor-host interactions. Non-classical leukocyte antigens (HLA) class Ib HLA-E, HLA-F, and HLA-G have previously described be involved protecting semi-allogeneic...
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and histopathological examination not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators gene expression were repeatedly proved to play important roles in pathogenesis GBM. In our study, we performed global miRNA profiling 58 glioblastoma tissue samples obtained during surgical...
Associated with the pathogenesis of many cancers, including brain tumors, microRNAs (miRNAs) present promising diagnostic biomarkers. These molecules have been also studied in cerebrospinal fluid (CSF), showing great potential as a tool patients tumors. Even though there are some biological and technological factors that could affect results their clinical interpretation, miRNA analysis CSF is not fully standardized. This study aims to compare several RNA extraction quantification...
Abstract Background Glioblastoma (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists a combination surgery subsequent oncological therapy, i.e., radiotherapy, chemotherapy, or their combination. If postoperative therapy involves irradiation, magnetic resonance imaging (MRI) used for radiotherapy planning. Unfortunately, in some cases, very early worsening (progression) return (recurrence) disease observed several weeks after called rapid progression...
Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques chemotherapy, median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure considered presence cells resistant to conventional therapy, mainly radiotherapy. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators gene expression have been...
Glioblastoma inevitably recurs, but no standard regimen has been established for treating this recurrent disease. Several reports claim that reoperative surgery can improve survival, the effects of reoperation timing on survival have rarely investigated. We, therefore, evaluated relationship between and in GBM. A consecutive cohort unselected patients (real-world data) from three neuro-oncology cancer centers was analyzed (a total 109 patients). All underwent initial maximal safe resection...
The aim of this retrospective study is to assess the incidence, localization, and potential predictors rapid early progression (REP) prior initiation radiotherapy in newly diagnosed glioblastoma patients compare survival outcomes cohorts with or without REP relation treatment. We assessed a consecutive cohort 155 histologically confirmed irradiated from 1/2014 12/2017. A total 90 preoperative, postoperative, planning MRI were analyzed. Median age 59 years, 59% men, 39 (43%) underwent gross...
Glioblastoma (GBM) is the most frequently occurring primary malignant brain tumor of astrocytic origin. To change poor prognosis, it necessary to deeply understand molecular mechanisms gliomagenesis and identify new potential biomarkers therapeutic targets. PIWI-interacting RNAs (piRNAs) help in maintaining genome stability, their deregulation has already been observed many tumors. Recent studies suggest that these molecules could also play an important role glioma biology. determine...
BACKGROUND AND OBJECTIVES: Meningioma, the most common primary intracranial tumor, presents challenges in surgical treatment because of varying tissue stiffness. This study explores molecular background meningioma stiffness, a critical factor planning and prognosis, focusing on utility microRNAs (miRNAs) as diagnostic biomarkers METHODS: Patients with meningiomas treated surgically at University Hospital Brno were included this study. Total RNA, isolated from tumor samples, underwent quality...