A5072380804- Biosensors and Analytical Detection
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Advanced Biosensing Techniques and Applications
- COVID-19 Clinical Research Studies
- Proteins in Food Systems
- Electrochemical Analysis and Applications
- Biochemical Acid Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cell Image Analysis Techniques
- Advanced Chemical Sensor Technologies
- Respiratory viral infections research
- Advanced biosensing and bioanalysis techniques
- Human Health and Disease
- Blood properties and coagulation
- Geochemistry and Geologic Mapping
- Viral gastroenteritis research and epidemiology
- Urinary Tract Infections Management
- Alzheimer's disease research and treatments
- SARS-CoV-2 detection and testing
- Advanced Fluorescence Microscopy Techniques
- Thermoregulation and physiological responses
- Heavy metals in environment
- Water Quality Monitoring Technologies
- Optical Coherence Tomography Applications
The University of Texas at Austin
2021-2025
University of Arizona
2019-2023
Age-dependent transition of metastable, liquid-like protein condensates to amyloid fibrils is an emergent phenomenon numerous neurodegeneration-linked systems. A key question whether the thermodynamic forces underlying reversible phase separation and maturation irreversible amyloids are distinct separable. Here, we address this using engineered version microtubule-associated Tau, which forms biochemically active condensates. Liquid-like Tau exhibit rapid aging under quiescent, cofactor-free...
Blood clotting is the body′s natural reaction in wound healing and also cause of many pathologies. Fibrin - main protein process provides clots′ mechanical strength by forming a scaffold complex fibrin fibers. fibers exhibit high extensibility primarily elastic properties under static loading, which differ from vivo dynamic forces. In biological materials, response changes repeated loading/unloading (cyclic loading). Using lateral force microscopy, we show possess viscoelastic behavior...
Pelvic organ prolapse (POP) is a gynecological disorder described by the descent of superior pelvic organs into or out vagina as consequence disrupted muscles and tissue. A thorough understanding etiology POP limited availability clinically relevant samples, restricting longitudinal studies on soft-tissue biomechanics structure to POP-induced models such fibulin-5 knockout ( FBLN5 -/- ) mice. Despite being principal constituent in extracellular matrix, little known about structural...
A straightforward method for classifying heavy metal ions in water is proposed using statistical classification and clustering techniques from non-specific microparticle scattering data. set of carboxylated polystyrene microparticles sizes 0.91, 0.75 0.40 µm was mixed with the solutions nine two control cations, measurements were collected at angles optimized non-aggregated aggregated particles. Classification these observations conducted compared among several machine learning techniques,...
Confocal microscopy provides optical sectioning that is invaluable for many applications, most notably imaging into thick samples. However, the high cost of commercial confocal microscopes limits uses to specialized research and clinical settings. We present a minimalistic line-scanning microscope costing less than $6,500 with performance comparable laser scanning system. The are shown through measurement axial line-spread function biological samples varying thickness. Comparison made...
The novel coronavirus caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has reached more than 160 countries and been declared a pandemic. SARS-CoV-2 infects host cells binding to the angiotensin-converting enzyme (ACE-2) surface receptor via spike (S) receptor-binding protein (RBD) on virus envelope. Global data similar infectious disease spread SARS-CoV-1 in 2002 indicated improved stability of at lower temperatures facilitating its high transmission community during colder months...
Abstract Pelvic organ prolapse (POP) is a gynecological disorder described by the descent of superior pelvic organs into or out vagina as consequence disrupted muscles and tissue. A thorough understanding etiology POP limited availability clinically relevant samples, restricting longitudinal studies on soft-tissue biomechanics structure to POP-induced models such fibulin-5 knockout ( FBLN5 -/- ) mice. Despite being principal constituent in extracellular matrix, little known about structural...