A5077735640- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Viral gastroenteritis research and epidemiology
- Toxin Mechanisms and Immunotoxins
- Gastrointestinal disorders and treatments
- Intestinal and Peritoneal Adhesions
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Gastroesophageal reflux and treatments
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Screening and Detection
- Microbial Metabolites in Food Biotechnology
- Genetic factors in colorectal cancer
- NF-κB Signaling Pathways
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
- Contemporary Literature and Criticism
- RNA modifications and cancer
Pasteur Institute of Iran
2015-2024
Iran Meteorological Organization
2022-2024
Iran Khodro (Iran)
2024
Biotechnology Research Center
2014-2024
Shahid Beheshti University of Medical Sciences
2024
Tehran University of Medical Sciences
2021
Royan Institute
2021
Academic Center for Education, Culture and Research
2021
Shariati Hospital
2008
University of Tehran
2008
Studies regarding the nature of cell-mediated immunity in Helicobacter pylori infection and its role pathogenesis have yielded controversial results. To address this issue a controlled manner, we employed well-characterized felis-mouse model. Immunized/challenged nonimmunized/infected mice were evaluated for cellular proliferation, gastric inflammation, cytokine Ab production at various times after infection. We observed two types immune responses depending on Ag preparation. The first...
In humans, Helicobacter pylori establishes a chronic infection which can result in various degrees of gastric inflammation, peptic ulcer disease, and predisposition to cancer. It has been suggested that bacterial virulence factors such as the vacuolating toxin (VacA) cytotoxin-associated gene product (CagA) may play major role determining clinical outcome infections. The host responses these varied outcomes received little attention. felis, does not express CagA or VacA, causes inflammation...
ABSTRACT Helicobacter pylori causes peptic ulceration and gastric adenocarcinoma; the latter is common in Iran but not Iraq. We hypothesized that more virulent H. strains may be found than Iraq so compared established newly described virulence factors from these countries. studied 59 unselected dyspeptic patients 49 cagA was similar proportions of both countries (76% versus 71% Iraq) significantly associated with ulcer disease ( P ≤ 0.01) Iran. alleles encoding four or tyrosine...
The Helicobacter pylori duodenal ulcer promoting (dupA) gene has been previously described as a risk marker for (DU) development and protective factor against gastric cancer (GC). Recent studies which have assessed the application of dupA in prediction clinical outcomes controversial. In current study, association with histopathological changes following H. infection was evaluated Iranian patients. A total 157 pylori-infected patients DU (n=30), (n=23), gastritis (n=68) or GC (n=36) were...
Abstract Background The Naive Bayes (NB) classifier is a powerful supervised algorithm widely used in Machine Learning (ML). However, its effectiveness relies on strict assumption of conditional independence, which often violated real-world scenarios. To address this limitation, various studies have explored extensions NB that tackle the issue non-conditional independence data. These approaches can be broadly categorized into two main categories: feature selection and structure expansion. In...
AIM:To examine the frequency of antibiotic resistance in Iranian Helicobacter pylori (H pylori) strains isolated from two major hospitals Tehran. METHODS:Examination was performed on 120 by modified disc diffusion test and PCR-RFLP methods.In addition, order to identify possible causes therapeutic failure Iran, we also determined these most commonly used antibiotics (metronidazole, amoxicillin, tetracycline) test. RESULTS:According test, 1.6% studied were resistant 16.7% clarithromycin,...
This paper focuses on a collection of eight loosely connected stories written by the Iranian dramatist and author Gholamhossein Sa‘edi under title The Mourners Bayal (1963). In fourth story, which is basis for scenario celebrated New Wave film, Cow (1969), narrator relates puzzling case farmer who has turned into his cow as result having lost it unexpectedly. ominous transformation Mash Hassan in Sa‘edi’s narrative prophetic reflection problem sovereignty Iran, positioned peripheries global...
<i>Background/Aim:</i> The identification of the <i>vacA </i>intermediate region has provided new insights into role <i>vacA</i> heterogeneity in relation to gastro-duodenal pathogenesis. aim this study was assess polymorphism Iranian <i>Helicobacter pylori </i>strains and its association with <i>cagA</i> as a major virulence determinant, gastric histopathology disease. <i>Methods:</i><i>vacA</i> serum...
Helicobacter pylori is a highly diverse pathogen, which encounters epithelial cells as the initial defense barrier during its lifelong infection. The structure of can be disrupted through cleavage microfilaments. Cytokeratin 18 (CK18) an intermediate filament, considered early event apoptosis following activation effector caspases.Helicobacter strains were isolated from 76 dyspeptic patients. cagA 3' variable region and CagA protein status analyzed by PCR western blotting, respectively....
Background: Multiple etiologic factors are suspected to cause gastric cancer, the most important of which is infection with virulent types Helicobacter pylori. Materials and Methods: We have compared 102 cancer patients 122 non-ulcer, non-cancer dyspeptic patients. Gastric specimens were evaluated for H. pylori by tissue-based detection methods. Patient sera underwent antigen-specific ELISA western blotting using a Helicoblot 2.1 kit antibody responses various antigens assessed. Results: The...
Attempts for early detection of gastric cancer have recently focused on host's genetic susceptibility factors and gene-environment interactions. We have, herein, studied the association MTHFR C677T single nucleotide polymorphism (SNP) its interaction with Helicobacter pylori infection, smoking, age gender risk among an Iranian population.Gastric patients (n = 450) cancer-free controls 780) were serum H. pylori-specific IgG antibodies by ELISA PCR-RFLP. Demographic life style data collected...
The aim of this study was to evaluate the prevalence chronic gastritis in pet dogs, determine histopathologic changes gastric mucosa and, its relationship with canine Helicobacter infection. Sixty percent (n = 18), 27% 8) and 13% 4) examined stomachs showed normal, congested erosive respectively. Histopathologic examination confirmed presence 40% dogs 12). Lymphocytic-plasmacytic most common type gastritis. Gastric detected cytological 26 out 30 (86.6%) but PCR analysis, 93% samples were...