A5018786774- Chronic Myeloid Leukemia Treatments
- Protein Tyrosine Phosphatases
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Treatment and Research
- PI3K/AKT/mTOR signaling in cancer
- Eosinophilic Disorders and Syndromes
- Genomic variations and chromosomal abnormalities
- Hemoglobinopathies and Related Disorders
- Prostate Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Multiple Myeloma Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Molecular Biology Techniques and Applications
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Acute Lymphoblastic Leukemia research
- Biochemical and Molecular Research
- Cancer-related Molecular Pathways
- Plant Virus Research Studies
- Urologic and reproductive health conditions
Associazione Istituzione Libera Università Nuorese
2021-2023
ATS Sardegna (Italy)
2008-2020
University of Verona
2006-2010
University of Bologna
2010
Azienda Ospedaliero Universitaria di Sassari
2009
Istituto di Chimica Biomolecolare
2009
University of Sassari
2009
University of Cagliari
1989-2006
Thomas Jefferson University
1994-1996
University of Ferrara
1995
Prostate-specific antigen (PSA) is widely used as a tumor marker of prostatic adenocarcinoma. We recently found that 30% breast tumors produce PSA and favorable prognostic in female cancer. measured immunoreactive cytosolic extracts normal tissue from eight women receiving no medication one woman who was the progestin-containing oral contraceptive Brevicon. None contained appreciable amounts PSA. However, left right tissues Brevicon high levels This species shown to have molecular weight...
The CTLA-4 molecule plays an important role in immune regulation by downregulating activation of T cells. Polymorphisms the gene have been shown to be associated a number autoimmune diseases including blood disorders. In this study, intragenic polymorphisms at position -318*C/T, +49*A/G, and dinucleotide (AT)(n) repeat polymorphism exon 3 were analyzed patients with non-Hodgkin's lymphoma. Genotype haplotype analysis showed that 1+49*AA genotype was over-represented among NHL (P = 0.002),...
Chronic myelogenous leukemia (CML) is the most common myeloproliferative disease. Protein tyrosine phosphatase receptor type γ (PTPRG) a tumor suppressor gene and myeloid cell marker expressed by CD34(+) cells. Downregulation of PTPRG increases colony formation in PTPRG-positive megakaryocytic lines MEG-01 LAMA-84 but has no effect PTPRG-negative K562 KYO-1. Its overexpression an oncosuppressive all these associated with differentiation inhibition BCR/ABL-dependent signaling. The...
Abstract In chronic lymphocytic leukemia, the reliability of next‐generation sequencing (NGS) to detect TP53 variants ≤10% allelic frequency (low‐VAF) is debated. We tested ability 23 such in 41 different laboratories using their NGS method choice. The sensitivity was 85.6%, 94.5%, and 94.8% at 1%, 2%, 3% VAF cut‐off, respectively. While only one false positive (FP) result reported >2% VAF, it more challenging distinguish true <2% from background noise (37 FPs by 9 laboratories)....
Protein tyrosine phosphatase receptor gamma (PTPRG) is a ubiquitously expressed member of the protein family known to act as tumor suppressor gene in many different neoplasms with mechanisms inactivation including mutations and methylation CpG islands promoter region. Although critical role human hematopoiesis an oncosuppressor chronic myeloid leukemia (CML) have been reported, only one polyclonal antibody (named chPTPRG) has described capable recognizing native antigen this by flow...
There is strong evidence that altered immunological function entails an increased risk of lymphoma, although the current knowledge aetiological factors for lymphomas limited. The CTLA4 gene encodes a receptor provides negative signal to T-cell once immune response initiated and completed. We analysed 2q33 chromosomal region harbouring CD28, ICOS genes, which are closely linked have related functions in regulation, association 100 non-Hodgkin's lymphoma (NHL) patients 128 healthy controls;...
Abstract Background In recent years, numerous studies have assessed the prevalence of germline mutations in BRCA1 and BRCA2 genes various cohorts. We here extensively investigated geographical distribution BRCA1-2 entire genetically-homogeneous Sardinian population. The occurrence phenotypic characteristics which may be predictive for presence was also evaluated. Methods Three hundred forty-eight breast cancer patients presenting a familial recurrence invasive or ovarian carcinoma with at...
Aberrant DNA methylation of promoter region CpG islands is an alternative mechanism that leads to genetic defects in the inactivation tumor suppressor genes during myelomagenesis. The aim this study was examine status phosphates and tensin homologue on chromosome 10 (PTEN) gene a cohort multiple myeloma patients.The PTEN hypermethylated 7 out 58 (12%) primary samples. correlation between functional mRNA levels not statistically significant. subgroup with aberrant had prevalence component...
A polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) not only differ in orientation but also copy-number. Although the processes driving spread of inversion-associated lineage (H2) humans remain unclear, a selective advantage has been proposed for one its subtypes. Here, we genotyped large panel individuals from previously overlooked populations using custom array with unique H2-specific single nucleotide polymorphisms found patchy...
Italy has been the first European Country dealing with SARS-CoV-2, whose diffusion on territory not homogeneous. Among Italian regions, Sardinia represented one of lowest incidence areas, likely due to its insular nature. Despite this, impact insularity SARS-CoV-2 genetic diversity comprehensively described.
Abstract Protein tyrosine phosphatase receptor gamma ( PTPRG ) is a member of the receptor-like family protein phosphatases and acts as tumor suppressor gene in different neoplasms. Recent studies reported down-regulation expression levels Chronic Myeloid Leukemia disease (CML). In addition, BCR-ABL1 transcript level currently key predictive biomarker CML response to treatment with Tyrosine Kinase Inhibitors (TKIs). The aim this study was employ flow cytometry monitor changes white blood...
Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression a natural inhibitory mechanism downregulated chronic myeloid (CML) disease. The behind its downregulation has not been fully elucidated yet.This study aimed to investigate the CpG status at PTPRG locus CML patients.Peripheral blood samples from patients time of diagnosis [no kinase inhibitors (TKIs)] (n = 13), failure (TKIs)...