A5043245758- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Advanced Proteomics Techniques and Applications
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Amino Acid Enzymes and Metabolism
- Bacteriophages and microbial interactions
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Connexins and lens biology
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Corrosion Behavior and Inhibition
- Urinary and Genital Oncology Studies
- Antibiotic Resistance in Bacteria
- Mine drainage and remediation techniques
- Microbial Community Ecology and Physiology
- Streptococcal Infections and Treatments
Federal Medical-Biological Agency
2018-2025
Moscow Institute of Physics and Technology
2016-2019
Federal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin
2015-2019
Center for Theoretical Problems of Physicochemical Pharmacology
2017
Escherichia coli (E. coli) has been increasingly implicated in the pathogenesis of Crohn's disease (CD). The phylogeny E. isolated from patients (CDEC) was controversial, and while genotyping results suggested heterogeneity, sequenced strains CD were closely related. We performed shotgun genome sequencing 28 isolates ten compared genomes these with already published other pathogenic non-pathogenic strains. CDEC shown to belong A, B1, B2 D phylogenetic groups. plasmid several operons...
Crohn's disease is associated with gut dysbiosis. Independent studies have shown an increase in the abundance of certain bacterial species, particularly Escherichia coli adherent-invasive pathotype, gut. The role these species this needs to be elucidated.We performed a metagenomic study investigating microbiota patients disease. A reconstruction consensus genome content was used assess genetic variability.The abnormal shifts microbial community structures were heterogeneous among patients....
Preclinical evaluation of PCA3 and AMACR transcript simultaneous detection in urine to diagnose clinical significant prostate cancer (prostate with Gleason score ≥7) a Russian cohort.We analyzed samples patients total serum PSA ≥2 ng/mL: 31 men scheduled for radical prostatectomy, 128 first diagnostic biopsy (prebiopsy cohort). PCA3, AMACR, GPI transcripts were detected by multiplex reverse transcription quantitative polymerase chain reaction, the results used scores calculation statistical...
Although modern methods of whole genome DNA methylation analysis have a wide range applications, they are not suitable for clinical diagnostics due to their high cost and complexity the large amount sample required analysis. Therefore, it is crucial be able identify relatively small number sites that provide precision sensitivity diagnosis pathological states. We propose an algorithm constructing limited subsamples from high-dimensional data form diagnostic panels. developed tool utilizes...
Abstract Background Proteomics of bacterial pathogens is a developing field exploring microbial physiology, gene expression and the complex interactions between bacteria their hosts. One complications in proteomic approach micro- macro-heterogeneity species, which makes it impossible to build comprehensive database genomes for identification, while most existing algorithms rely largely on genomic data. Results Here we present large scale study identification single amino acid polymorphisms...
BACKGROUND: Decreased skeletal muscle mass and properties lead to the development of various pathologies increased risk for injuries. Studies molecular mechanisms adaptation resistance training increase strength appear imperative medicine sports. AIM: To assess changes in proteomic profile (quantitative panoramic spectrometric analysis) muscles correlation these with expression corresponding mRNAs (RNA-sequencing) before after 12 weeks transcriptome 8 24 h an acute exercise one leg. METHODS:...
Here, we report the draft genome sequences of green sulfur bacterium Chlorobium phaeovibrioides strains GrTcv12 and PhvTcv-s14, isolated from chemocline zone meromictic Lake Trekhtzvetnoe, separated White Sea, in Russia. This is first showing presence plasmids containing antiphage systems sp. genome.
One of the dysbioses often observed in Crohn's disease (CD) patients is an increased abundance Escherichia coli (10-100 fold compared to healthy individuals) (Gevers et al., 2014). The data reported a large-scale proteome profile for E. isolates collected from CD and individuals. 43 were achieved 30 (17 male, 12 female, median age 30) 19 7 individuals (7 19). Isolates cultivated on LB medium at aerobic conditions up log phase. Protein extraction was performed with sodium deoxycholate (DCNa)...
Cancer immunotherapy represents a promising and rapidly developing approach for the treatment of oncological diseases. Among methods personalized adjuvant immunotherapy, neoantigenic peptide-based drugs have demonstrated substantial efficiency. These are designed to target mutant proteins arising from somatic alterations in genome tumor cells thus stimulate immune response against tissues. The individual screening potentially immunogenic mutations mostly based on next-generation exome...