A5102850061- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Poxvirus research and outbreaks
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Streptococcal Infections and Treatments
- Vaccine Coverage and Hesitancy
- Bacillus and Francisella bacterial research
- Telemedicine and Telehealth Implementation
- Adolescent Sexual and Reproductive Health
- Hepatitis C virus research
- Reproductive tract infections research
- Pharmaceutical Practices and Patient Outcomes
- Infectious Encephalopathies and Encephalitis
- Bacterial Infections and Vaccines
- Medication Adherence and Compliance
- Syphilis Diagnosis and Treatment
- COVID-19 and healthcare impacts
Yale University
2016-2025
Centre Hospitalier Universitaire Ibn Rochd
2025
Office of Infectious Diseases
2024
Yale Cancer Center
2018-2022
Gilead Sciences (Australia)
2018
Griffin Hospital
2002
Context Complicated left-sided native valve endocarditis causes significant morbidity and mortality in adults. Lack of valid data regarding estimation prognosis makes management this condition difficult. Objective To derive externally validate a prognostic classification system for adults with complicated endocarditis. Design, Setting, Patients Retrospective observational cohort study conducted from January 1990 to 2000 at 7 Connecticut hospitals among 513 patients older than 16 years who...
COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It widely recognized as a pathogen, but neurologic complications can be presenting manifestation in subset of infected patients.
A DIagnosis of inhalational anthrax in a media outlet employee Florida marked the recognition first confirmed outbreak associated with bioterrorism United States.3][4][5] Direct exposure to envelopes containing Bacillus anthracis or contaminated postal equipment was likely 9 patients.The 10th reported patient resident New York, NY, and nature her is currently unknown.The 11th bioterrorism-related identified Connecticut described this article. CASE REPORTOn November 16, 2001, 94-year-old...
Introduction: Scaling up vaccination against COVID-19 is central to controlling the epidemic in United States. Several vaccines are now approved for prevention of COVID-19, but public concerns over safety and efficacy have heightened distrust vaccine hesitancy. This particularly concerning among people with HIV (PWH) who may be vulnerable more severe disease. Here, we aimed identify understand hesitancy a sample PWH U.S. Methods: We conducted cross-sectional online survey between 6 December...
ABSTRACT Elite controllers (ECs) are a rare group of HIV seropositive individuals who able to control viral replication without antiretroviral therapy. The mechanisms responsible for this phenotype, however, have not been fully elucidated. In study, we examined CD4 + T cell resistance in cohort elite and explored transcriptional signatures associated with cellular resistance. We demonstrate that subgroup possess cells specifically resistant R5-tropic while remaining susceptible X4-tropic...
Effective and safe COVID-19 vaccines have been developed resulted in decreased incidence severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can decrease secondary transmission. However, there are concerns about dampened immune responses to vaccination among immunocompromised patients, including people living with HIV (PLWH), which may blunt the vaccine's efficacy durability protection. This study aimed assess qualitative SARS-CoV-2 vaccine immunogenicity PLWH...
Abstract Immunological memory mediates rapid protection following infection or vaccination including heterologous exposure. However, cross-reactive responses in humans remain poorly characterized. We explored the longevity and specificity of cross-protective to orthopoxviruses through smallpox Mpox virus (MPXV) infection. Smallpox using Vaccinia (VACV)-based vaccines provides a unique opportunity study long-term immunity without antigen re-exposure. assessed systemic mucosal four human...
Abstract Background To end the HIV and hepatitis C virus (HCV) epidemics, people who use drugs (PWUD) need more opportunities for testing. While inpatient hospitalizations are an essential opportunity to test HCV, there is limited research on rates of testing HCV among PWUD. Methods Eleven hospital sites were included in study. Each site created a cohort encounters associated with injection drug use. From these cohorts, we collected data consent policies from 65 276 PWUD hospitalizations....
Abstract Background Data are limited on implementation of long-acting injectable (LAI) HIV treatment (ART) and preexposure prophylaxis (PrEP). We characterized “early adopters” LAI ART PrEP in terms social determinants health using a equity lens. Methods Our retrospective cohort included patients prescribed or through large urban system (January 2021–September 2023) the Northeastern United States. used electronic record data for to examine group differences between those oral medications...
Retroperitoneal fibrosis (RPF), also known as Ormond's disease, is a rare and progressive condition characterized by the formation of abnormal fibroinflammatory tissue in retroperitoneum.It can be idiopathic or secondary to infiltrative, infectious, malignant diseases.Retroperitoneal associated with tuberculosis particularly form, complex diagnosis poorly understood pathophysiological mechanisms.At same time, Takayasu's vasculitis primarily affecting aorta its major branches, triggered Case...
Abstract Background More than half of people living with HIV in the United States are 50 years age or older. Understanding how best to assess and address conditions associated aging primary care is important for this population. Methods We trained clinicians an academic clinic 4F’s (polypharmacy, Falls, Fragility Fractures) their patients (PAH). share results screening as well key knowledge, attitudes, practices (KAP) from pre-test assessment our clinician champions. Results 126 50+ were...
Abstract Background Elite controllers are people living with HIV (PLWH) who maintain their viral load (VL) < 50 copies/mL without antiretroviral therapy (ART). Viremic persons have able to keep VL 2000 ART. Current published data does not clearly define the benefits of ART nor adverse effects in elite controllers. Evaluation on immune activation, inflammatory markers, mitochondrial and cellular function can better inform utilization this group. Methods Four PLWH—3 1 viremic...
Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control. We aimed assess the magnitude, specificity, durability of cross-reactive elicited by smallpox vaccines mpox virus infection. did a multicohort observational study involving participants from USA, Brazil, Portugal across four groups: Dryvax (first-generation vaccine) recipients vaccinated 40-80 years ago, JYNNEOS (third-generation...
Abstract Background Among the 1.2 million people with human immunodeficiency virus (HIV) in United States, 25% are coinfected hepatitis C (HCV). The availability of effective direct acting antivirals (DAAs) makes goal HCV elimination feasible, but implementation requires improvements to treatment cascade, especially linkage and initiation underserved populations. Methods In this retrospective review, a cohort patients receiving care at hospital-based HIV clinic New Haven, Connecticut...
Approximately 215 million Americans have been fully vaccinated for COVID-19, representing over 65% of the total population. People with HIV (PWH) may be more susceptible to COVID-19 infection or severe disease, elevating importance vaccination uptake in We report results from a national survey PWH evaluate likelihood receiving vaccine. conducted an online 1,030 living United States between December 6, 2020 and January 8, 2021 Overall, participants were highly willing vaccinated, 83.8%...
Very-low-level viremia (VLLV) is a relatively new concept in the realm of human immunodeficiency virus (HIV) care. Newer generation assays are now able to detect plasma HIV RNA Viral Load (VL) levels as low 20 copies/mL. The authors characterized patients with VLLV (VL between and 50 copies/mL) order identify possible risk factors associated virologic failure poor clinical outcomes.The reviewed 119 consecutive charts VLLV. Sociodemographic data were extracted viral load CD4 counts trended...
Abstract Background Late diagnosis of human immunodeficiency virus (HIV) is associated with increased morbidity and mortality, represents a serious public health concern. Methods A retrospective medical record review was conducted on 188 patients newly diagnosed HIV at large academic center’s clinic from 1/2010 to 12/2019. Patient demographic data, staging, response combination antiretroviral therapy (cART) as measured by viral suppression 12 weeks (HIV RNA < 50 copies) were collected....
Since the first reported case in December 2019, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million people and claimed over 500,000 lives worldwide. Although SARS-CoV-2 is widely recognized as a pathogen, an increasing number of dermatologic manifestations virus exist. Here we report unilateral laterothoracic exanthem association with SARS-CoV-2.
OBJECTIVE Mortality in hospitalized human immunodeficiency virus (HIV)‐infected patients is not well described. We sought to characterize in‐hospital deaths among HIV‐infected the antiretroviral (ART) era and identify factors associated with mortality. METHODS reviewed medical records of who died from January 1, 1995 December 31, 2011 at an urban teaching hospital. evaluated trends early late ART use due acquired syndrome (AIDS) non‐AIDS, identified clinical demographic correlates non‐AIDS...