A5014631069- CAR-T cell therapy research
- Neuroscience and Neural Engineering
- Corneal surgery and disorders
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Glaucoma and retinal disorders
- EEG and Brain-Computer Interfaces
- interferon and immune responses
- Corneal Surgery and Treatments
- Photoreceptor and optogenetics research
- Immune Cell Function and Interaction
- Vestibular and auditory disorders
- CRISPR and Genetic Engineering
- Ophthalmology and Visual Impairment Studies
- Advanced Memory and Neural Computing
- Molecular Biology Techniques and Applications
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Intraocular Surgery and Lenses
- Spine and Intervertebral Disc Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Ocular Surface and Contact Lens
University Hospital of Zurich
2022-2025
University of Zurich
2023-2024
ETH Zurich
2024
Leipzig University
2014-2023
University Hospital Leipzig
2013-2015
RWTH Aachen University
2006-2011
Charité - Universitätsmedizin Berlin
2007
purpose. Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of neurons implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety efficacy a wireless intraocular implant (EPIRET3) six volunteers RP. methods. The is remotely controlled, fully device consisting receiver stimulator module. placed on surface. Data energy are transmitted via an inductive link from outside eye implant. Surgery included...
Abstract TP53 -mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option for AML/MDS. However, the impact of deficiency in AML cells on efficacy CAR is unknown. We here show that engaging -deficient exhibit prolonged interaction time, upregulate exhaustion markers, inefficient to control cell outgrowth vitro vivo compared...
Visual sensations in blind patients suffering from retinal degenerations may be restored by electrical stimulation of neurons using implantable microelectrode arrays. The EPI-RET-3 project was initiated to evaluate a wireless intraocular implant system for human use terms safety and efficiency. is remotely controlled fully prosthesis consisting receiver stimulator module. placed onto the retina's surface. Data energy are transmitted via an inductive link outside eye implant. device implanted...
Abstract Missense mutants of p53 - such as the frequent hotspot variant R248Q exert a dominant-negative effect (DNE) on wildtype (WT) in cancer cells with monoallelic TP53 mutations. However, precise functional and molecular mechanisms DNE have remained elusive due to lack appropriate model systems. Here, we developed variety systems, including CRISPR-edited human isogenic cell lines transcriptional reporter lines, targeted protein degradation assays that were combined analyses functionally...
CAR T-cell products targeting lineage-specific cell-of-origin antigens, thereby eliminating both tumor and healthy counterpart cells, are currently clinically approved therapeutics in B- plasma-cell malignancies. While they represent a major clinical improvement, still limited terms of efficacy by e.g. single, sometimes low-expressed antigen targeting, safety e.g., lack on-off activity. Successful non-discriminative heterogeneous hematopoietic stem progenitor cell malignancies, such as acute...
Optical coherence tomography (OCT) is an established diagnostic tool for retinal pathologies in human eyes and has been adapted to small animal models. However, there have only a few attempts use OCT examination of avian eyes, little known about structural details healthy or pathologically affected retinas living birds.We used SD-OCT (high-resolution spectral domain OCT) investigate various species including birds prey. The were anesthetized by isoflurane application during examination. Eyes...
Background Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological events, however, have not methodically been described and studied. Furthermore, safety data on CAR-T therapy in patients with central nervous system (CNS) lymphoma remain limited. Main body We here report occurrence Guillain-Barré-like (GBS) diabetes insipidus (cDI) following tisagenlecleucel for relapsed...
A wireless epiretinal retina implant system, capable of stimulating the retinal ganglion cells in blind Retinitis Pigmentosa (RP) patients, was developed. The prosthesis itself is completely implanted into eyeball, with no cable crossing eyepsilas wall. Data and energy are provided by inductive coupling. based on a flexible polyimide tape an integrated receiver coil, stimulation electrodes microchips. system six legally patients for four weeks. All reported visual sensations, evoked...
Abstract Objective Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment obesity. Since activation Fas (CD95) induces pathways known to blunt expression uncoupling protein 1 (UCP1), we hypothesized that adipocytes inhibits WAT thus contributes development Methods Adipocyte‐specific knockout (Fas Δadipo ) control littermate F/F mice were fed a regular chow diet or high‐fat (HFD) 20 weeks. Energy was assessed by...
Abstract Purpose To determine the visco‐elastic properties of isolated rabbit scleral tissue and dose‐dependent biomechanical morphological changes after collagen cross‐linking by riboflavin/blue light treatment. Material Scleral patches from 87 adult albino eyes were examined dynamic shear rheology. treated riboflavin different intensities blue (450 nm), impact on was determined various rheological test regimes. The relative elastic modulus calculated non‐treated corresponding patches,...
Abstract Background The chemokines, CXCL12 and CXCL11, are upregulated in tumors from many organs control their progression. CXCL11 affect tumor cell functions by either binding prime receptors, CXCR4 CXCR3, respectively, and/or CXCR7 as a common second chemokine receptor. In humans, CXCR3 exists the functional splice variants, CXCR3A CXCR3B, which have pro- or anti-tumor activity, respectively. Despite intimate crosstalk between CXCL12- CXCL11-system, impact of combination on progression...
Abstract Acute myeloid leukemia (AML) derives from hematopoietic stem and progenitor cells (HSPCs). To date, no AML‐exclusive, non‐HSPC‐expressed cell‐surface target molecules for AML selective immunotherapy have been identified. Therefore, to still apply surface‐directed in this disease setting, time‐limited combined immune‐targeting of healthy HSPCs, followed by cell transplantation (HSCT), might be a viable therapeutic approach. explore this, we generated recombinant single‐chain variable...
The 2-year-old sheep is a frequently used model in spinal orthopaedic research; however, so far no investigations have been performed on physiological tissue of untreated animals. In this study, the cervical spine segment 3/4 eight female Merino was evaluated histologically and histomorphometrically. Specimens were stained with Masson-Goldner-Trichrome, Safranin-Orange/Lightgreen, Safranin-Orange/von Kossa Astrablue. Analysis bone mass, mass cartilage mineralized defined region interest...
MR safety and compatibility are important issues for all devices used within an environment. testing of medical is required device approval by the regulatory agencies worldwide. Besides basic also computer modeling electromagnetic fields SAR distribution passive has been established. Further methods numerical analysis currently under development active implantable devices. The will be published soon as ISO Technical Specification listing such RF- gradient-induced voltages, heating, vibration...
<title>Abstract</title> CAR T-cell products targeting lineage-specific cell-of-origin antigens, thereby eliminating both tumor and healthy counterpart cells, are currently clinically approved therapeutics in B- plasma-cell malignancies. While they represent a major clinical improvement, still limited terms of efficacy by e.g. single, sometimes low-expressed antigen targeting, safety lack on-off activity. Successful non-discriminative heterogeneous hematopoietic stem progenitor cell...