A5025096061- RNA and protein synthesis mechanisms
- Archaeology and Historical Studies
- Ancient Mediterranean Archaeology and History
- Origins and Evolution of Life
- Nanopore and Nanochannel Transport Studies
- Lipid Membrane Structure and Behavior
- RNA Research and Splicing
- Force Microscopy Techniques and Applications
- Bacterial Genetics and Biotechnology
- Historical, Religious, and Philosophical Studies
- Geotechnical and Geomechanical Engineering
- Oral and Craniofacial Lesions
- Museums and Cultural Heritage
- Oral and gingival health research
- Oral Health Pathology and Treatment
- Supramolecular Chemistry and Complexes
- DNA and Biological Computing
- Chemical Synthesis and Analysis
- Metallurgy and Cultural Artifacts
- Ancient Near East History
- European Political History Analysis
- Forensic Anthropology and Bioarchaeology Studies
- Mining Techniques and Economics
- Mass Spectrometry Techniques and Applications
- Linguistics and Cultural Studies
Technical University of Munich
2024-2025
Excellence Cluster Origins
2024
Abstract One of science’s greatest challenges is determining how life can spontaneously emerge from a mixture molecules. A complicating factor that and its molecules are inherently unstable—RNA proteins prone to hydrolysis denaturation. For the de novo synthesis or better understand emergence at origin, selection mechanisms needed for unstable Here we present chemically fuelled dynamic combinatorial library model RNA oligomerization deoligomerization shine new light on purification under...
Recent experiments have shown that the diffusion coefficient of some metabolic enzymes increases with concentration their cognate substrate, a phenomenon known as enhanced diffusion. In presence substrate gradients, induces enzymatic drift, resulting in non-homogeneous enzyme distribution. Here, we study effects on enzyme-loaded vesicles placed external gradients using combination computer simulations and analytical modeling. We observe spatially inhomogeneous profiles generated by result...
The transition from prebiotic chemistry to living systems requires the emergence of a scheme for enzyme-free genetic replication. Here, we analyze recently proposed replication scenario, so-called Virtual Circular Genome (VCG) [Zhou et al., RNA 27, 1-11 (2021)]: Replication takes place in pool oligomers, where each oligomer contains subsequence circular genome, such that oligomers encode full genome collectively. While sequence may be reconstructed based on long short merely act as...
The transition from prebiotic chemistry to living systems requires the emergence of a scheme for enzyme-free genetic replication. Here, we analyze recently proposed replication scenario, so-called Virtual Circular Genome (VCG) [Zhou et al., RNA 27, 1-11 (2021)]: Replication takes place in pool oligomers, where each oligomer contains subsequence circular genome, such that oligomers encode full genome collectively. While sequence may be reconstructed based on long short merely act as...
The diffusion coefficient of some metabolic enzymes increases with the concentration their cognate substrate, a phenomenon known as enhanced diffusion. In presence substrate gradients, induces enzymatic drift, resulting in nonhomogeneous enzyme distribution. Here, we study effects on enzyme-loaded vesicles placed external gradients using combination computer simulations and analytical modeling. We observe that spatially inhomogeneous profiles generated by result pressure gradient across...
The transition from prebiotic chemistry to living systems requires the emergence of a scheme for enzyme-free genetic replication. Here, we analyze recently proposed replication scenario, so-called Virtual Circular Genome (VCG) [Zhou et al., RNA 27, 1-11 (2021)]: Replication takes place in pool oligomers, where each oligomer contains subsequence circular genome, such that oligomers encode full genome collectively. While sequence may be reconstructed based on long short merely act as...
In RNA world scenarios, pools of oligomers form strongly interacting, dynamic systems, which enable molecular evolution. such pools, hybridize and dehybridize, ligate break, ultimately generating longer molecules, may fold into catalytically active ribozymes. A key process for the elongation is templated ligation, can occur when two strands are adjacently hybridized onto a template strand. Detailed simulations dynamics in involve large variety possible sequences reactions. Here, we develop...
<title>Abstract</title> One of science’s greatest challenges is how life can spontaneously emerge from a mixture abiotic molecules. A complicating factor that inherently unstable, and, by extension, so are its molecules—RNA and proteins prone to hydrolysis denaturation. For the synthesis or better understand emergence at origin, selection mechanisms needed for such unstable Here, we present chemically-fueled dynamic combinatorial library as model RNA oligomerization deoligomerization shines...