A5040413100- Origins and Evolution of Life
- Photoreceptor and optogenetics research
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Micro and Nano Robotics
- Chemical Synthesis and Analysis
- Mass Spectrometry Techniques and Applications
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Electrohydrodynamics and Fluid Dynamics
- Chemical Reaction Mechanisms
- Lipid Membrane Structure and Behavior
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photosynthetic Processes and Mechanisms
- Advanced Chemical Physics Studies
- DNA and Biological Computing
- Gene Regulatory Network Analysis
- Advanced Thermodynamics and Statistical Mechanics
- Microtubule and mitosis dynamics
Technical University of Munich
2021-2025
Abstract One of science’s greatest challenges is determining how life can spontaneously emerge from a mixture molecules. A complicating factor that and its molecules are inherently unstable—RNA proteins prone to hydrolysis denaturation. For the de novo synthesis or better understand emergence at origin, selection mechanisms needed for unstable Here we present chemically fuelled dynamic combinatorial library model RNA oligomerization deoligomerization shine new light on purification under...
In dynamic combinatorial libraries, molecules react with each other reversibly to form intricate networks under thermodynamic control. biological systems, chemical reaction operate kinetic control by the transduction of energy. We thus introduced notion energy transduction, via cycles, a library. library, monomers can be oligomerized, oligomers deoligomerized, and recombine. Interestingly, we found that dynamics library's components were dominated transacylation, which is an equilibrium...
Abstract RNA is an information‐carrying molecule that instructs protein synthesis, but it also functions as a catalyst in so‐called ribozymes. Here, we study this multifunctional character using dynamic combinatorial library powered by chemical fuel. On the one hand, demonstrate templates oligomerization and inhibits deoligomerization. other show can be structural element formation of hydrogels. Moreover, its hydrogel, degradation nucleases accelerated. Thus, have role beyond blueprints,...
Biology uses chemical potential differences from molecules like ATP to drive membrane pumps, transporting across membranes even against concentration gradients. Here, we report a synthetic system that transports small an aqueous phase (the sender) receiver centimeter‐sized immiscible solvent at the expense of energy. Molecules with high (fuels) in sender transiently activate transporter molecules, which enter and exit on side, thus allowing transport gradient. Importantly, show this active...
Biology uses chemical potential differences from molecules like ATP to drive membrane pumps, transporting across membranes even against concentration gradients. Here, we report a synthetic system that transports small an aqueous phase (the sender) receiver centimeter‐sized immiscible solvent at the expense of energy. Molecules with high (fuels) in sender transiently activate transporter molecules, which enter and exit on side, thus allowing transport gradient. Importantly, show this active...
Division is crucial for replicating biological compartments and, by extension, a fundamental aspect of life. Current studies highlight the importance simple vesicular structures in prebiotic conditions, yet mechanisms behind their self-division remain poorly understood. Recent research suggests that environmental factors can induce phase transitions fatty acid-based protocells, leading to vesicle fission. However, using chemical energy division, similar extant life, has been less explored....
Division is crucial for replication of biological compartments and by extension a fundamental aspect life. Current studies highlight the importance simple vesicular structures in prebiotic conditions, yet mechanisms behind their self-division remain poorly understood. Recent research suggests that environmental factors can induce phase transitions fatty acid-based protocells, leading to vesicle fission. However, transduction role chemical energy facilitating division has been less explored....
The synthesis of life from non-living matter has captivated scientists for centuries. It is a grand challenge aimed at unraveling the fundamental principles and leveraging its unique features, such as resilience, sustainability, ability to evolve. Synthetic holds immense potential in biotechnology, medicine, materials science. Advancements synthetic biology, systems chemistry, biophysics have brought us closer achieving this ambitious goal. Researchers successfully assembled cellular...
Abstract Nature uses dynamic, molecular self‐assembly to create cellular architectures that adapt their environment. For example, a guanosine triphosphate (GTP)‐driven reaction cycle activates and deactivates tubulin for dynamic assembly into microtubules. Inspired by in biology, recent studies have developed synthetic analogs of assemblies regulated chemically fueled cycles. A challenge these is control the interplay between rapid disassembly kinetic trapping building blocks known as...
Abstract Lipids spontaneously assemble into vesicle‐forming membranes. Such vesicles serve as compartments for even the simplest living systems. Vesicles have been extensively studied constructing synthetic cells or models protocells—the hypothesized to existed before life. These exist almost always close equilibrium. Life, however, exists out of In this work, we vesicle‐based regulated by a non‐equilibrium chemical reaction network that converts activating agents. way, require constant...
Abstract Lipids spontaneously assemble into vesicle‐forming membranes. Such vesicles serve as compartments for even the simplest living systems. Vesicles have been extensively studied constructing synthetic cells or models protocells—the hypothesized to existed before life. These exist almost always close equilibrium. Life, however, exists out of In this work, we vesicle‐based regulated by a non‐equilibrium chemical reaction network that converts activating agents. way, require constant...
Division is crucial for replication of biological compartments and by extension a fundamental aspect life. Current studies highlight the importance simple vesicular structures in prebiotic conditions, yet mechanisms behind their self-division remain poorly understood. Recent research suggests that environmental factors can induce phase transitions fatty acid-based protocells, leading to vesicle fission. However, transduction role chemical energy facilitating division has been less explored....
Abstract The front cover artwork is provided by BoekhovenLab at TU Munich. image shows an energy landscape of kinetically trapped chemically fueled supramolecular fibers, which reminds a mountain landscape. Read the full text Research Article 10.1002/syst.202200035 .
Lipids can spontaneously assemble into vesicle-forming membranes. Such vesicles serve as compartments for even the simplest living systems. Vesicles have been extensively studied constructing synthetic cells or models protocells—the hypothesized to existed before life. These exist almost always close equilibrium. Life, however, exists out of In this work, we vesicle-based regulated by a non-equilibrium chemical reaction network that converts activating agents. Specifically, use agents...
Biology uses chemical potential differences from molecules like ATP to drive membrane pumps, transporting across mem-branes even against concentration gradients. Here, we report a synthetic system that transports small an aqueous phase (the sender) receiver centimeter-sized immiscible solvent at the expense of energy. Molecules with high (fuels) in sender transiently activate transporter molecule enter and exit on side, thus allowing transport gradient. Importantly, show this active...
Lipids can spontaneously assemble into vesicle-forming membranes. Such vesicles serve as compartments for even the simplest living systems. Vesicles have been extensively studied constructing synthetic cells or models protocells—the hypothesized to existed before life. These exist almost always close equilibrium. Life, however, exists out of In this work, we vesicle-based regulated by a non-equilibrium chemical reaction network that converts activating agents. Specifically, use agents...
Nature uses dynamic, molecular self-assembly to create cellular architectures that adapt their environment. For example, a guanosine triphosphate (GTP)-driven reaction cycle activates and deactivates tubulin for assembly into microtubules disassembly. Inspired by dynamic in biology, multiple studies have developed synthetic analogs of assemblies regulated chemical chemically fueled cycles. A challenge most these is molecules assemble upon activation but do not disassemble deactivation. In...
<title>Abstract</title> One of science’s greatest challenges is how life can spontaneously emerge from a mixture abiotic molecules. A complicating factor that inherently unstable, and, by extension, so are its molecules—RNA and proteins prone to hydrolysis denaturation. For the synthesis or better understand emergence at origin, selection mechanisms needed for such unstable Here, we present chemically-fueled dynamic combinatorial library as model RNA oligomerization deoligomerization shines...