A5024696558- Fibroblast Growth Factor Research
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
The Netherlands Cancer Institute
2022-2023
Oncode Institute
2023
Abstract Somatic hotspot mutations and structural amplifications fusions that affect fibroblast growth factor receptor 2 (encoded by FGFR2 ) occur in multiple types of cancer 1 . However, clinical responses to FGFR inhibitors have remained variable 1–9 , emphasizing the need better understand which alterations are oncogenic therapeutically targetable. Here we apply transposon-based screening 10,11 tumour modelling mice 12,13 find truncation exon 18 (E18) Fgfr2 is a potent driver mutation....
The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at NH2-terminus proteins, thereby influencing their biological properties. A number studies have implicated QPCTL in regulation chemokine stability. Furthermore, activity has recently been shown to be critical for high-affinity SIRPα binding site CD47 "don't-eat-me" protein. Based on latter data, interference with —and hence maturation—may proposed as a means promote...
Targeting the PI3K-AKT-mTOR pathway is a promising therapeutic strategy for breast cancer treatment. However, low response rates and development of resistance to inhibitors remain major clinical challenges. Here, we show that MYC activation drives mTOR (mTORi) in cancer. Multiomic profiling mouse invasive lobular carcinoma (ILC) tumors revealed recurrent Myc amplifications acquired mTORi AZD8055. was associated with biological processes linked counteracted mTORi-induced translation...
The spectrum of background, incidental, and experimentally induced lesions affecting NSG NOG mice has been the subject intense investigation. However, comprehensive studies focusing on spontaneous neuropathological changes these immunocompromised strains are lacking. This work describes development early-onset neurodegeneration both juvenile adult NSG, NOG, NXG mice. study cohort consisted 367 sexes (including 33 NSG-SGM3), 61 females 31 NOG-EXL), 4 females. These animals were primarily used...