A5031170152- Nonlinear Waves and Solitons
- Nonlinear Photonic Systems
- Fibroblast Growth Factor Research
- Advanced Fiber Laser Technologies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Advanced Mathematical Physics Problems
- Dust and Plasma Wave Phenomena
- VLSI and Analog Circuit Testing
- Metaheuristic Optimization Algorithms Research
- Chronic Myeloid Leukemia Treatments
- Cold Atom Physics and Bose-Einstein Condensates
- Peptidase Inhibition and Analysis
- Algebraic structures and combinatorial models
- Formal Methods in Verification
- Software Engineering Research
- Model-Driven Software Engineering Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vehicle Routing Optimization Methods
- Advanced Multi-Objective Optimization Algorithms
- Natural Language Processing Techniques
- Scheduling and Optimization Algorithms
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
Incyte (United States)
2016-2025
Yichang Central People's Hospital
2024
China Three Gorges University
2024
Huawei Technologies (China)
2021-2024
Huawei Technologies (Sweden)
2022-2024
University of South Carolina
2006-2022
Beijing University of Posts and Telecommunications
2012-2018
City University of Hong Kong
2018
State Key Laboratory of Information Photonics and Optical Communications
2015-2016
Abstract Pemigatinib, a selective FGFR1–3 inhibitor, has demonstrated antitumor activity in FIGHT-202, phase II study patients with cholangiocarcinoma harboring FGFR2 fusions/rearrangements, and gained regulatory approval the United States. Eligibility for FIGHT-202 was assessed using genomic profiling; here, these data were utilized to characterize landscape of uncover unique molecular features rearrangements. The results highlight high percentage potentially actionable alterations...
FGFR2 rearrangements resulting in dysregulated signaling are drivers of cholangiocarcinoma (CCA) tumorigenesis, and occur almost exclusively intrahepatic CCA. Pemigatinib, a selective, potent, oral inhibitor FGFR1-3, has demonstrated efficacy safety Phase II study patients with previously treated locally advanced/metastatic CCA harboring fusions/rearrangements. We describe the design FIGHT-302, an open-label, randomized, active-controlled, multicenter, global, III comparing first-line...
•FIGHT-202 evaluated pemigatinib in patients with previously treated, advanced/metastatic CCA FGFR2 rearrangements.•Median follow-up was 45.4 months; demonstrated an ORR of 37% and a median DOR 9.1 months.•Median PFS OS were 7.0 17.5 months, respectively.•AEs treatment manageable; during extended follow-up, no new safety signals identified.•The importance tumor molecular profiling efficacy fusions/rearrangements are described. BackgroundFibroblast growth factor receptor 2 (FGFR2) fusions...
RESPONSE is an open-label phase 3 study evaluating the Janus kinase 1/Janus 2 inhibitor ruxolitinib versus best available therapy for efficacy/safety in hydroxyurea-resistant or intolerant patients with polycythemia vera. This preplanned analysis occurred when all completed Week 80 visit discontinued. Objectives included durability of primary response (Week 32 phlebotomy-independent hematocrit control plus ≥35% spleen volume reduction), its components, and that complete hematologic...
Abstract Somatic hotspot mutations and structural amplifications fusions that affect fibroblast growth factor receptor 2 (encoded by FGFR2 ) occur in multiple types of cancer 1 . However, clinical responses to FGFR inhibitors have remained variable 1–9 , emphasizing the need better understand which alterations are oncogenic therapeutically targetable. Here we apply transposon-based screening 10,11 tumour modelling mice 12,13 find truncation exon 18 (E18) Fgfr2 is a potent driver mutation....
Summary The randomized, double‐blind, double‐dummy, phase 3b RELIEF trial evaluated polycythaemia vera ( PV )‐related symptoms in patients who were well controlled with a stable dose of hydroxycarbamide (also termed hydroxyurea) but reported ‐related symptoms. Patients randomized 1:1 to ruxolitinib 10 mg BID n = 54) or (prerandomization dose/schedule; 56); crossover was permitted after Week 16. primary endpoint, ≥50% improvement from baseline myeloproliferative neoplasm ‐symptom assessment...
Multi-task learning is a powerful method for solving multiple correlated tasks simultaneously. However, it often impossible to find one single solution optimize all the tasks, since different might conflict with each other. Recently, novel proposed Pareto optimal good trade-off among by casting multi-task as multiobjective optimization. In this paper, we generalize idea and propose algorithm (Pareto MTL) set of well-distributed solutions which can represent trade-offs tasks. The first...
This work is geared toward a real-world manufacturing planning (MP) task, whose two objectives are to maximize the order fulfillment rate and minimize total cost. More important, requirements constraints in real make MP task very challenging several aspects. For example, needs cover many production components of multiple plants over 30-day horizon, which means that it involves large number decision variables. Furthermore, task's have extremely different magnitudes, some difficult handle....
Optical rogue waves of the coupled nonlinear Schr\"odinger equations with negative coherent coupling, which describe propagation orthogonally polarized optical in an isotropic medium, are reported. We construct and discuss a family vector rogue-wave solutions, including bright waves, four-petaled dark waves. A wave without valley can split up, giving birth to two eye-shaped
For the interaction between high-frequency Langmuir waves and low-frequency ion-acoustic in plasma, Zakharov equations are studied this paper. Via Hirota method, we obtain soliton solutions, based on which propagation is presented. It found that with λ increasing, amplitude of u decreases, whereas v remains unchanged, where speed, slowly-varying envelope wave, fluctuation equilibrium ion density. Both head-on bound-state interactions two solitons displayed. We observe decreasing, period...
The extended Zakharov-Kuznetsov (eZK) equation for the magnetized two-ion-temperature dusty plasma is studied in this paper. With help of Hirota method, bilinear forms and N-soliton solutions are given, soliton propagation graphically analyzed. We find that amplitude positively related to nonlinear coefficient A, while inversely dispersion coefficients B C. obtain will increase with mass jth dust grain average charge number residing on decreased, but equilibrium density increased. Upon...
This paper reviews the recent literature on solving Boolean satisfiability problem (SAT), an archetypal $$\cal{N}\cal{P}$$ -complete problem, with aid of machine learning (ML) techniques. Over last decade, society advances rapidly and surpasses human performance several tasks. trend also inspires a number works that apply methods for SAT solving. In this survey, we examine evolving ML solvers from naive classifiers handcrafted features to emerging end-to-end solvers, as well progress...
Due to the growing complexity of modern Integrated Circuits (ICs), there is a need for automated circuit design methods. Recent years have seen rising research in hardware language generation facilitate process. In this work, we propose Verilog framework, BetterV, which fine-tunes large models (LLMs) on processed domain-specific datasets and incorporates generative discriminators guidance particular demands. The modules are collected, filtered from internet form clean abundant dataset....
Abstract Objectives Polycythemia vera ( PV )‐related symptoms may not be adequately controlled with conventional therapy. This current analysis of the RESPONSE trial evaluated effects ruxolitinib compared standard therapy on quality life (QoL) and in patients who were hydroxyurea resistant/intolerant. Methods In previously reported primary analysis, achieved composite endpoint hematocrit control ≥35% reduction spleen volume at Week 32. The patient‐reported outcomes using European...
Covariance matrix adaptation evolution strategy (CMA-ES) is a successful gradient-free optimization algorithm. Yet, it can hardly scale to handle high-dimensional problems. In this paper, we propose fast variant of CMA-ES (Fast CMA-ES) large-scale black-box We approximate the covariance by low-rank with few vectors and use two them generate each new solution. The algorithm achieves linear internal complexity on dimension search space. illustrate that underlying distribution be considered as...