A5101835836- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Pharmacological Effects of Natural Compounds
- Distributed and Parallel Computing Systems
- Dermatologic Treatments and Research
- Flavonoids in Medical Research
- Covalent Organic Framework Applications
- Machine Learning in Bioinformatics
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Advanced Malware Detection Techniques
- Skin Protection and Aging
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Innovations in Medical Education
- Nuts composition and effects
- Phytochemicals and Antioxidant Activities
- Receptor Mechanisms and Signaling
- Laser Applications in Dentistry and Medicine
- Physical Unclonable Functions (PUFs) and Hardware Security
- Medicinal Plants and Bioactive Compounds
- Drug Transport and Resistance Mechanisms
- Pharmacovigilance and Adverse Drug Reactions
- Spam and Phishing Detection
Georgia Institute of Technology
2023-2025
Liaoning Technical University
2025
Qiqihar University
2023-2024
Zhejiang University
2022-2023
Jilin University
2020-2023
Worcester Polytechnic Institute
2020
First Hospital of Jilin University
2020
University of Michigan
2016-2018
ZTE (China)
2017
Shaanxi Research Association for Women and Family
2008
Isochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and considered to have potential effects. The activation IDH1 as a pathway development anticancer drugs not been attempted. We demonstrated that can limit glycolysis in hepatocellular carcinoma (HCC) cells activate tumor immune microenvironment. In addition, through proteomic microarray analysis, we identified natural small molecule, scutellarin (Scu),...
Emodin, a naturally occurring compound derived from anthraquinone, demonstrates notable efficacy in combating oxidative stress, protecting neural tissues, and inhibiting malignant cell proliferation. This bioactive phytochemical has garnered significant scientific attention due to its multifaceted therapeutic potential, particularly the context of oncological interventions neurodegenerative disorder management. The neuroprotective capacity emodin preventing dopaminergic neuronal demise...
Abstract During its first month, the recently emerged 2019 Wuhan novel coronavirus (2019-nCoV) has already infected many thousands of people in mainland China and worldwide took hundreds lives. However, swiftly spreading virus also caused an unprecedentedly rapid response from research community facing unknown health challenge potentially enormous proportions. Unfortunately, experimental to understand molecular mechanisms behind viral infection design a vaccine or antivirals is costly takes...
Rationale Huahong tablet, a commonly used clinical Chinese patent medicine, shows good efficacy in treating pelvic inflammation and other gynaecological infectious diseases. However, the specific composition of tablets, which are complex herbal formulations, remains unclear. Therefore, this study aims to identify active compounds targets tablets investigate their mechanism action inflammatory Methods We utilised ultrahigh‐performance liquid chromatography Q‐Exactive‐Orbitrap mass...
DNS protocol has been used by many malwares for command-and-control (C&C). To improve the resiliency of C&C communication, Domain Generation Algorithm (DGA) utilized recent such as Locky, Conficker and Zeus. Many detection systems have introduced DGA-based botnets detection. However, approaches suffer from several limitations, instance, requiring a group DGA domains, period behaviors, presence multiple bots, so forth. It is very hard them to detect an individually running malware which leave...
In order to revise the deviation caused by ignoring dynamic character of fault propagation in traditional path identification methods, a method based on maximum occurrence probability is proposed identify key path. Occurrence defined importance, and rate. Taking information CNC machine tools which subject Weibull distribution as an example, this has been proven be reasonable through comparative analysis. Result shows that not unique, but changes with time. Before 1000 hours, electrical...
Abundant ribonucleoside-triphosphate (rNTP) incorporation into DNA by polymerases in the form of ribonucleoside monophosphates (rNMPs) is a widespread phenomenon nature, resulting DNA-structural change and genome instability. The rNMP distribution, characteristics, hotspots association with metabolic processes human mitochondrial (hmtDNA) remain mostly unknown. Here, we utilize ribose-seq technique to capture embedded rNMPs hmtDNA six different cell types. In most types, are preferentially...
Epimedium is a traditional Chinese medicine with wide range of clinical applications; however, there have been numerous reports adverse reactions in recent years. The most common side effect liver injury. In this study, the liquid chromatography-mass spectrometry (LC-MS) method has established to study components and identify absorbed into blood rats. Bioinformatics was used screen out potential toxic components, integrating metabolomics explore molecular mechanism Epimedium-induced chemical...
During its first month, the recently emerged 2019 Wuhan novel coronavirus (SARS-CoV-2) has already infected many thousands of people in mainland China and worldwide took hundreds lives. However, swiftly spreading virus also caused an unprecedentedly rapid response from research community facing unknown health challenge potentially enormous proportions. Unfortunately, experimental to understand molecular mechanisms behind viral infection design a vaccine or antivirals is costly takes months...
It has been widely adopted to deploy low-precision CNN model inference on FPGAs for edge applications, such as target detection or graph classification, where convolution is always the most time-consuming kernel because it introduces massive multiplications. The existing work shows that quantized kernels well inference. Typically, 4-bit precision enough guarantee accuracy. When deploying FPGAs, state-of-the-art approach TiNNA implements three multiplications within a DSP block, e.g., 27x18...
Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of non-Hodgkin's lymphoma, which has an aggressive clinical course and extremely poor prognosis. Chidamide novel, orally active, benzamide-type histone deacetylase (HDAC) inhibitor that been used for peripheral (PTCL) treatment. However, to date, there no report the treatment effect HDAC chidamide in HSTCL, special PTCL.A 45-year-old male patient was admitted with splenomegaly slight bicytopenia. He diagnosed HSTCL via splenectomy. The...
With increasing computation of various applications, dynamic voltage and frequency scaling (DVFS) is gradually deployed on FPGAs. However, its reliability security haven't been sufficiently evaluated. In this paper, we present a practical DVFS fault attack targeting at the SkyNet accelerator IP successfully destroy detection accuracy. no knowledge about internal structure, our can achieve more than 98% accuracy loss under ten vulnerable operating point pairs (OPPs). Meanwhile, explore local...
Recent advances in large language models have brought immense value to the world, with their superior capabilities stemming from massive number of parameters they utilize. However, even GPUs highest memory capacities, currently peaking at 80GB, are far sufficient accommodate these vast and associated optimizer states when conducting stochastic gradient descent-based optimization. One approach hosting such huge is aggregate device many GPUs. this introduces prohibitive costs for most academic...
Abstract Motivation Ribonucleoside monophosphates (rNMPs) are the most abundant non-standard nucleotides embedded in genomic DNA. If presence of rNMP DNA cannot be controlled, it can lead to genome instability. The actual regulatory functions rNMPs remain mainly unknown. Considering association between embedment and various diseases cancer, phenomenon has become a prominent area research recent years. Results We introduce rNMPID database, which is first database revealing rNMP-embedment...
Rationale Although Naomaitai capsule (NMC) is widely used in clinical practice and has a good curative effect for cerebral infarction, its material basis mechanism of action remain unclear. Methods In this study, ultra‐high‐performance liquid chromatography (UHPLC) coupled with quadrupole Orbitrap MS technology was to analyse the vivo vitro components NMC, Global Natural Products Social Molecular Networking website further NMC. Next, systems biology approaches were employed investigate...
The present study aimed to systematically analyse the differences in metabolites, proteins, and microbiota among white sufu (WS), red (RS), grey (GS) by integrating multi‐omics detection techniques. First, various metabolites were identified through widely targeted metabolomics. Then, differential proteins screened, principal functions of further mined using proteomic Finally, analysed via 16S rRNA sequencing technology observe microbial composition. results showed that approximately 306...
This study analyzed adverse drug event (ADE) signals associated with metreleptin using the FDA Adverse Event Reporting System (FAERS) to provide insights for safe clinical use.