A5100664517- Research in Cotton Cultivation
- Smart Agriculture and AI
- Endoplasmic Reticulum Stress and Disease
- Plant Molecular Biology Research
- Congenital Ear and Nasal Anomalies
- Industrial Technology and Control Systems
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Pancreatic function and diabetes
- Plant nutrient uptake and metabolism
- Advanced Sensor and Control Systems
- Plant and Fungal Interactions Research
- Hippo pathway signaling and YAP/TAZ
- Risk Management in Financial Firms
- Cancer-related gene regulation
- Plant Gene Expression Analysis
- Advanced Glycation End Products research
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Insect Utilization and Effects
- Polysaccharides and Plant Cell Walls
- Advanced Measurement and Detection Methods
- Advanced Decision-Making Techniques
- Congenital heart defects research
- Cleft Lip and Palate Research
Huazhong Agricultural University
2020-2025
Capital Medical University
2025
Beijing Tongren Hospital
2025
Chinese Academy of Agricultural Sciences
2024
Jinzhou Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
University of Rhode Island
2023
Beihang University
2022
Shanghai Jiao Tong University
2022
Shanghai Cancer Institute
2022
Abstract The conversion of serine and glycine that is accomplished by hydroxymethyltransferase 2 (SHMT2) in mitochondria significantly upregulated various cancers to support cancer cell proliferation. In this study, we observed SHMT2 acetylated at K95 colorectal (CRC) cells. SIRT3, the major deacetylase mitochondria, responsible for deacetylation. SHMT2-K95-Ac disrupts its functional tetramer structure inhibits enzymatic activity. also promotes degradation via K63-ubiquitin–lysosome pathway...
Abstract CD4+ Th1 and Th17 cells both can cause autoimmune diseases, either alone or collaboratively, if left unchecked. However, what determines the dominant Th effector phenotype in a specific disease remains poorly understood. Our present investigation shows that null mutation of IEX-1 promotes differentiation but compromises survival cells. The differential effect gave rise to greater number cells, higher level IL-17 production, more severe arthritis knockout mice than wild-type after...
Genome-wide characterization by next-generation sequencing has greatly improved our understanding of the landscape epigenetic modifications. Since 2008, whole-genome bisulfite (WGBS) become gold standard for DNA methylation analysis, and a tremendous amount WGBS data been generated research community. However, systematic comparison profiles to identify regulatory mechanisms yet be fully explored. Here we reprocessed raw over 500 publicly available Arabidopsis libraries from various mutant...
Abstract Interspecific genomic introgression is an important evolutionary process with respect to the generation of novel phenotypic diversity and adaptation. A key question how gene flow perturbs expression networks regulatory interactions. Here, population two species allopolyploid cotton ( Gossypium ) delineate perturbations regarding fiber development accompanying quality change utilized. De novo assembly recipient parent G. hirsutum Emian22) genome allowed identification variation...
Transposable element (TE) expansion has long been known to mediate genome evolution and phenotypic diversity in organisms, but its impact on the of post-transcriptional regulation following species divergence remains unclear. To address this issue, we perform long-read direct RNA sequencing, polysome profiling small sequencing cotton genus Gossypium, which range more than three folds size. We find that TE contributes turnover transcription splicing sites regulatory sequences, leading changes...
Retinal vascular diseases are typified by the proliferation of irregular and leaky microvessels, resulting in vision impairment. Although etiology retinal angiogenesis is not yet fully understood, it evident that microglia play a pivotal role promoting angiogenesis. Methods: In vivo, METTL14 conditional knockout (cKO) mouse was constructed to investigate oxygen-induced retinopathy (OIR). vitro, combination methylated RNA immunoprecipitation sequencing (MeRIP-seq), RNA-sequencing (RNA-seq),...
Retinal ganglion cells (RGCs) are among the first neurons to undergo apoptosis in diabetic retinopathy (DR), with their relationship endoplasmic reticulum stress (ERS)-induced still unclear. While glucocorticoid-induced transcript 1 (GLCCI1) has been shown inhibit apoptosis, its role ERS-induced and mechanisms DR remain unclarified. Our findings indicated that GLCCI1 is predominantly localized cell layer downregulated DR. overexpression mitigated of RGCs swelling mitochondria under...
The glucosyltransferases, Rab-like GTPase activators and myotubularins (GRAM) domain is highly conserved in eukaryotic cells found proteins involved membrane-associated processes. GRAM have not yet been functionally characterized cotton. In this study, we identified 164 genes encoding four cotton species, comprising two subfamilies. Gossypium hirsutum, our transcriptome data showed that GhGRAM31 was predominantly expressed during the rapid elongation stage of fiber development it might...
<title>Abstract</title> Transposable element (TE) expansion has long been known to mediate genome evolution and phenotypic diversity in organisms, but its impact on the of posttranscriptional regulation following species divergence remains unclear. To address this issue, we performed long-read direct RNA sequencing, polysome profiling small sequencing cotton genus <italic>Gossypium</italic>, which range more than 3-fold size. We found that TE contributed turnover transcription splicing sites...
Herein, a combined multipoint picking scheme was proposed, and the sizes of end bud picker were selectively designed. Firstly, abstracted as fixed-size box, it assumed that tea buds in box have certain probability being picked. Then, coverage greedy algorithm designed to make few numbers set possible cover all reduce picking. Furthermore, Graham minimum bounding applied fine-tune footholds each optimal set, so concentrated middle boxes much possible. Moreover, geometric center taken point,...
Congenital heart disease (CHD) is the most common birth defect and often accompanied by neurodevelopmental disabilities (NDD) which increase associated mortality. Plexin families are known to play a key role in development of occurrence anomalies. However, there has been no report PLXNB3 mutation isolated CHD or with concomitant NDD.We performed whole-exome sequencing (WES) on proband anomalies his family members. Targeted sequencing, conservation analysis, AlphaFold, PyRosetta were identify...
Long non-coding RNAs (lncRNAs) have been identified as influential indicators in variety of malignancies. Among which, LncRNA RUNDC3A-AS1 is reported to upregulate thyroid cancer. However, the expression pattern and pathological function lncRNA cancer unclear. In this study, we examined levels tissues cell lines via RT-qPCR analysis. The effects on metastasis were detected by transwell chamber assay, scratch assay vitro lung model vivo . results indicated that was highly expressed lines....
At present, citrus is mainly harvested manually with low efficiency and high cost, thereby resulting in an imminent demand for fruit-harvesting robot. Hence, recognizing locating from complex backgrounds using machine vision technology the premise a key robots to harvest them. To accurately immediately recognize mature citrus, this study proposes novel method based on Otsu adaptive threshold improved random ring method. First, region was segmented overthe V component of Luminance Chrominance...
<title>Abstract</title> Background Mitochondrial dysfunction plays a crucial role in retinal ganglion cells (RGCs) injury, the early pathogenesis of diabetic retinopathy (DR). G protein-coupled receptor 75 (GPR75), an orphan receptor, is novel regulator metabolic diseases. However, and mechanisms GPR75 underlying RGCs mitochondrial has not been reported. Methods High glucose (HG)-treated streptozotocin (STZ)-induced C57BL/6 mice were used present study. GPR75-knockdown adeno-associated virus...
Cases of microtia combined with pulmonary hypoplasia are occasionally in clinics, and its genetic etiology has so far proved inconclusive. Here, aiming to contribute a better understanding microtia-related comorbid respiratory anomalies, the authors provide clinical description rare trio family which son suffers deformities right microtia, left hypoplasia, dextrocardia using whole-genome sequence (WGS). A novel potential pathologic compound heterozygosity FREM1 gene was identified validated...
Sika deer velvet antler is the most important animal nutraceutic in traditional Chinese medicine. Reducing breeding cost of sika by looking for a low-cost diet main research direction at present. The purpose this experiment was to find an alternative and reduce using spent mushroom substrate (SMS) as concentrate supplement. apparent digestibility doe hematological changes suckling fawn were measured replacing 10% supplement with SMS Pleurotus ostreatus (SMS-MP). Compared control group, dry...