About
Contact & Profiles
A5093614125
Research Areas
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Zebrafish Biomedical Research Applications
IRCCS Humanitas Research Hospital
2023
Triggering receptor expressed on myeloid cells 2 (Trem2) is a cell-specific gene in brain microglia, with variants that are associated neurodegenerative diseases, including Alzheimer's disease. Trem2 essential for microglia-mediated synaptic refinement, but whether contributes to shaping neuronal development remains unclear. Here, we demonstrate plays key role controlling the bioenergetic profile of pyramidal neurons during development. In absence Trem2, developing hippocampal cornus ammonis...
10.1016/j.immuni.2023.12.002
article
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cc-by-nc
Immunity
2023-12-29
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