A5041570055- Lymphoma Diagnosis and Treatment
- Public Health and Nutrition
- Cancer, Hypoxia, and Metabolism
- Hibiscus Plant Research Studies
- Methodologies in Health Research and Practice
- Viral-associated cancers and disorders
- Medicinal Plant Research
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac tumors and thrombi
- Thyroid Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Retinoids in leukemia and cellular processes
- Pancreatic and Hepatic Oncology Research
- Computer Science and Engineering
- Retinopathy of Prematurity Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Tea Polyphenols and Effects
- Phytochemistry and biological activities of Ficus species
- Agricultural and Biological Research
- Indonesian Legal and Regulatory Studies
- Curcumin's Biomedical Applications
- Tannin, Tannase and Anticancer Activities
- Legal and Policy Analysis in Indonesia
- Corneal surgery and disorders
Diponegoro University
2019-2025
Dr. Kariadi Hospital
2021-2024
Background: Indonesia is a tropical country that has high exposure to UV radiation causes. To overcome these effects, antioxidants are needed can inhibit the effects of radiation. Clitoria ternatea, which rich in flavonoids, able fight free radicals and reduce photoaging. Objective: This study aims determine effect ternatea extract cream on number fibroblasts collagen thickness UVB-induced male white rats. Methods: was true experimental type with post-test only control group design 36 White...
The diagnosis of thyroid neoplasms necessitates the identification distinct histological features. Various education/hospital centers located in cities across Indonesia likely result discordances among pathologists when diagnosing neoplasms.
While the association of hypoxia has been established in various types solid cancers, little is known about its presence and existence diffuse large B-cell lymphoma (DLBCL). The purpose present study was to evaluate expression hypoxia-inducible factor-1α (HIF-1α) vascular endothelial growth factor A (VEGF-A) DLBCL analyze these factors with several clinical pathological characteristics. immunohistochemical protein HIF-1α VEGF-A investigated 34 de novo tumor samples from January 2017 December...
Atherosclerosis is a complex pathological process begins with endothelial dysfunction, one of which triggered by an inflammatory due to increased levels low-density lipoprotein (LDL) cholesterol and exposure cigarette smoke. White tea leaf (Camellia sinensis) shows anti-inflammatory effect has not been known for its on the atherosclerotic process. The aim this study determine Camellia sinensis extract IL-6 levels, foam cell count, ratio intima-media thickness smoke high-fat diet-induced...
Background: Breast cancer is the most common type of malignancy in women. Many studies report that characteristics and prognosis young-aged breast carcinoma are worse than old age. Data on Indonesia relatively lacking always needs updates.Objective: To determine incidence distribution based histological profiles clinical stage, as well association between molecular subtype with grade stage (<40 years old) at Dr. Kariadi General Hospital Center 2018-2020.Methods: This research was an...
Latar Belakang: Obesitas merupakan faktor risiko yang signfikan untuk perkembangan banyak penyakit, salah satunya gangguan pernapasan. Pada orang mengalami obesitas, deposit jaringan adiposa dapat menyebabkan penurunan dimensi saluran napas bagian atas dan meningkatkan resistensi aliran udara. Massa tubuh tinggi peningkatan kebutuhan oksigen dengan demikian pasien harus bernapas frekuensi lebih atau volume besar setiap inspirasi. Tujuan: Mengetahui hubungan obesitas derajat sumbatan hidung....
Hypoxia fuels cancer growth by supporting blood vessel formation, suppressing immune response, and helping cells adapt to harsh surroundings. This happens when react low oxygen levels activating hypoxia inducible factor-1 alpha (HIF-1α). High of HIF-1α can indicate an aggressive form resistance treatment in diffuse large B-cell lymphoma (DLBCL) patients. study aimed identify which factors are linked distribution using immunohistochemistry DLBCL patients.This conducted at a hospital Indonesia...
Background: In the new normal era, face masks are very important for everyday use. Masks began to be developed involving herbal plants with anti-inflammatory and antibacterial potential. This study aims prove potential of KN95 Acchadana® Herbal Masks. Methods: randomized control trial has 50 laboratory workers as subjects. Subjects were divided into two groups. The group wore KN95® (n=25), treatment (n=25, 1 dropout). Each a mask 60 days. Then nasal wash sample was taken test IL-6 levels...
Abstract
 Introduction & Objectives : To prove the effect of oral curcumin on NMDA receptor expression and retinal ganglion cell density.
 Methods Wistar rats model traumatic optic neuropathy were divided into 2 groups. The treatment group was given 150mg/kgBW/24 hours for 14 days 1 hour after trauma. examined by IHC staining density HE staining. Data collected analyzed.
 Results found to be significantly lower in compared control (p = 0.046). mean 12.88 ± 2.44 17.92 6.95,...
Abstract
 Introduction & Objectives : Traumatic optic neuropathy is a visual disturbance caused by acute injury to the nerve which results in retinal ganglion cell apoptosis through glutamate excitotoxicity pathway. Brimonidine an alpha 2-receptor agonist that acts as neuroprotector pathway and causes modulation of NMDA receptors associated with glutamate. Objective this study prove effect topical brimonidine on receptor expression density rat model traumatic neuropathy
...
Introduction & ObjectivesRetinal ganglion cell (RGC) damage can affect the thinning of GCC layers, which is nervefiber layer, layer and inner plexiform layer. The loss RGC plexiformlayer (IPL) strongly correlated with visual field defect. layerare potential targets to evaluate progression glaucoma. Glaucoma treatment not only focus onreducing IOP. Decreasing IOP according target pressure often can’t stop process RGCdamage make it permanently irreversible. Vitamin D3 known as...
Introduction & ObjectivesGlaucoma is a disorder characterized by the presence of optic neuropathy. Visual impairment inglaucoma caused retinal ganglion cell (RGC) apoptosis associated with N-methyl-D-aspartate(NMDA)-mediated excitotoxicity. Excitotoxicity causes an increase in calcium cells as well asactivation caspase-3. Glaucoma therapy currently given to reduce intraocular pressure (IOP),but damage still progressing progressively. Hesperidin known neuroprotector that cansuppress...
Abstract
 Introduction & Objectives : Traumatic optic neuropathy is a visual disturbance condition after acute injury to nerve. This results in retinal ganglion cells ischemic leading excitotoxicity and apoptosis. Coenzyme Q10 (CoQ10) an antioxidant cofactor electron transport within mitochondria that inhibits glutamate thereby preventing cell research aims prove the effect of coenzyme on NMDA receptor expression density rat model traumatic neuropathy.
 Methods study use...
Background: Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy remains the standard of first-line treatment for diffuse large B-cell lymphoma (DLBCL). Up to 40% DLBCL is characterized by relapse refractory after treatment. Preliminary study reported Hypoxia-inducible factor-1? (HIF-1?) overexpression in 88.5% tumors Dr. Kariadi Hospital. Moreover, role hypoxia HIF-1? has previously never been explored DLBCL. Objectives: To evaluate effect modulation...
Background: Diabetes mellitus (DM) is a chronic metabolic disease that can cause microvascular and macrovascular complications. The formation of superoxide (O2-) by dysfunctional mitochondria in diabetes has been recognised as major driver diabetic Consequently, the utilisation antioxidants may prove advantageous. plant Andredera cordifolia contains flavonoids, which act antioxidants.Objective : to investigate effect binahong leaf extract on development atherosclerosis carotid...
Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid antioxidant and hydrogen peroxide which stimulate fibroblasts proliferation angiogenesis on healing phase.Objective: to determine the effect of in second degree from number Wistar rats. Methods: This research posttest only controlled group design 15 rats with random selection divided into 3 groups: H-G was given honey, B-G...
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin in Asia and Indonesia. DLBCL could be further classified according to cell origin as germinal center (GCB) subtype or non-germinal (non-GCB) subtypes; these, non-GCB usually has poorer prognosis. The purpose this study determine relationship between cell-origin 3-year overall survival patients with at Kariadi General Hospital Semarang.This research represents an observational analytical 36 who visited January August...
Latar Belakang : Epilepsi adalah salah satu kelainan neurologi kronik yang ditandai dengan gejala khas yaitu kejang berulang akibat lepasnya muatan listrik neuron otak secara berlebihan dan paroksismal. Salah pengobatan epilepsi OAE. Pada keadaan dimana telah mengonsumsi 2 atau lebih jenis OAE teratur adekuat selama 18 bulan namun tidak menunjukkan penurunan frekuensi durasi kejang, hal ini disebut intraktabel. Pengetahuan mengenai faktor berpengaruh pada kejadian intraktabel anak penting...
Background: DLBCL is the most common type of NHL in world. based on cell origin divided into GCB and non-GCB. The diagnosis has not been routinely done to its origin, there have many studies that discuss subtype overall survival patients, especially Kariadi General Hospital. This study aims determine correlation with 2-year patients Methods: an observational analytic 40 Hospital from January August 2017. data collection including: age diagnosis, location, stage survival. Data analysis used...
Background: Prostate cancer is one the most common malignancy in men worldwide, and acinar adenocarcinoma prevalent one. Gleason score grade group recently used to predict therapy prognosis based on pattern. Her-2 Ki-67 are markers that widely studied breast cancer, but their role prostate still unclear. a transmembrane protein involved oncogenesis. We hope by using basic determinant pattern analyze expression of these two markers, it will contribute understand its carcinogenesis prognosis....
Background: A wound is a disorder of the continuity epithelial layer skin or mucosa and can result from physical thermal damage. Proliferation remodeling processes are important phases in incision healing. Celery believed to have potential regulate inflammatory phase accelerate process proliferation tissue. This study aims evaluate potency celery extract (Apium graveolens (Linn)) on healing vivo.
 Methods: was an vivo experimental study. total 24 rats were used this divided into 4...