Background:The combined effects of metformin and epigallocatechin-3-gallate (EGCG) on cortisol, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), blood glucose levels have not been investigated.This study evaluated the effectiveness combining EGCG with in regulating those a rat model diet-induced diabetes obesity.Methods: Thirty diabetic obese rats high-fat diet were treated daily for 28 days (100 mg/kg body weight/day), (200 or both.Control groups comprised lean rats, untreated...

Cholestasis causes liver cirrhosis due to chronic total obstruction, in which accumulated bile acids induce inflammation and fibrosis. Inflammatory conditions are associated with hypoalbuminemia, changes albumin levels indicate the patient's clinical condition. Allium sativum has anti-inflammatory, antioxidant, antifibrotic effects against various diseases. Further, ursodeoxycholic acid (UDCA) is one of few available therapies for cirrhosis. Thus, this study aimed assess combination A. UDCA...

Sepsis is a severe medical condition characterized by an excessive inflammatory response to infection, often leading organ failure, particularly in the heart. Cardiac dysfunction sepsis results from multiple mechanisms and significantly worsens patient prognosis. Given limited therapeutic options for sepsis, there urgent need explore new substances that can help modulate response. This study aimed evaluate effects of Andrographis paniculata on transcription factors proinflammatory cytokines,...

Background: Moringa provides extra dietary benefits. The immune system is significantly influenced by the nine necessary amino acids, calcium, iron, potassium, magnesium, zinc, and vitamins A, C, E, B that are included in this food. Previous studies state moringa causes liver kidney damage. Another study found has an abortive effect.Objectives: This aimed to determine how exposure kelor (moringa oleifera) leaf extract affected hepar pregnant mice secondary metabolite of leaves.Materials...

Indonesia has a long experience in traditional medicine such as jamu. The government been encouraging all sectors, especially pharmaceutical industries together with research institutions and academia to increase herbal so that is increasingly used health services, including by medical doctors. Various efforts have made but empirically it seems this goal not achieved. For reason, necessary conduct survey determine the understanding use of among I was cross-sectional study using an electronic...

In vivo studies on the hazards of deep-fried foods were commonly done by feeding used-or heated-cooking oil to rats. The aim this study was determine effect

This study aimed to examine the effectiveness of ozonated Aloe vera oil on wound healing response full-thickness defect tissue in Sprague-Dawley rats, assessed by collagen thickness and number fibroblasts. was an experimental research method using control groups treatment with a posttest only group design. The results showed that wounds tended increase, day 3 7 Masson's trichrome staining microscopic evaluation. There significant difference fibroblasts between two days tested one-way...

Curcumin is a naturally occurring compound that has antioxidant properties, acts as hepatoprotective, and lowers lipid peroxidation. However, curcumin's low solubility bioavailability are its primary drawbacks prevent use therapeutic agent. In this study, curcumin nanoparticles will be created using the ultrasonic-assisted extraction method, their effectiveness against paracetamol-induced changes in ALT, AST, SOD, MDA, TNF-α compared to of pure curcumin.This study aimed determine...

BACKGROUND: Andrographis paniculata has anti-inflammatory, anti-cancer, and immunomodulatory effects. Intercellular adhesion molecule-1 (ICAM-1) E-selectin are released in inflammatory conditions due to sepsis. In sepsis-associated fatalities, is strongly expressed on pulmonary microvasculature ICAM-1 endothelial cells, macrophages, lymphocytes. Therefore, this study was conducted analyze the protective effect of A. leaf extract against lung injury lipopolysaccharide (LPS)-induced sepsis...

Phycocyanin from Spirulina platensis extract has anticancer activity against various types of cancer cell cultures. However study about its effect on colon lines, especially the WiDr, not been reported before. This aimed to reveal phycocyanin WiDr cells. The research was an in vitro experimental study, with investigation cytotoxicity also antiproliferation as parameters. Both and test conducted through MTT assay observe visualization inhibition proliferation different concentrations several...

Background: Associated with sepsis is the illness known as acute kidney injury (AKI). AKI may be mediated by uric acid, and blood creatinine levels can utilized to diagnose condition measure function. Sambiloto (Andrographis paniculata) a traditional medicine that has flavonoid compounds reduce Xanthine Oxidase Inhibitors which acid levels.Objective: Septic model rats generated lipopolysaccharide were used test effects of sambiloto leaf extract on serum (LPS).Methods: This study was...

Background: C-reactive protein (CRP) and ferritin are acute-phase reactants that have demonstrated association with the severity of a variety inflammation-mediated illnesses, including infection sepsis. Sambiloto (Andrographis paniculata) leaf is traditionally used as an anti-inflammation anti-bacterial herb. extract possesses anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant activitiesObjective: To evaluate effect on inflammation biomarker (CRP serum ferritin) in...

Atherosclerosis is a complex pathological process begins with endothelial dysfunction, one of which triggered by an inflammatory due to increased levels low-density lipoprotein (LDL) cholesterol and exposure cigarette smoke. White tea leaf (Camellia sinensis) shows anti-inflammatory effect has not been known for its on the atherosclerotic process. The aim this study determine Camellia sinensis extract IL-6 levels, foam cell count, ratio intima-media thickness smoke high-fat diet-induced...

Introduction: It is not yet known how Caesalpinia sappan L. extract (CSE) affects the activity of SOD and MDA levels in rats exposed to inhaled formaldehyde. Method: This true experimental study vivo uses a randomized post-test-only control group design. The subjects were male Sprague Dawley, 2-4 months old, weight 200-300 grams, total 30 heads divided into 6 groups. treatment was given CSE at doses 0, 100, 400, 1000 g/kg BW for 28 days, formaldehyde 2 weeks, 8 hours/day. measured using...

Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory plebotonic medicines, high fiber diet changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory medicine) since its effect may related antioxidant property.
 ObjectiveTo elaborate the anti-oxidant of GP on experimental in male Wistar rats.
 MethodsA Randomized Controlled Trial Post-test only design hemorrhoid-like...

Latar belakang : Cisplatin dapat menyebabkan penurunan sistem hemopoetik akibat Radical oxygen spesies (ROS) pada penderita kanker kepala dan leher (KKL). Kombinasi vitamin C E dosis tinggi sebagai antioksidan dari luar diperlukan untuk menetralisir ROS. Tujuan penelitian ini adalah membuktikan bahwa kombinasi mengurangi KKL cisplatin.
 Metode Penelitian eksperimental pre-post test design. Subyek yang memenuhi kriteria inklusi klinik bangsal THT-KL RSUP Dr. Kariadi Semarang dilakukan...

Latar Belakang: Kelor memiliki zat yang bermanfaat sebagai  gastroproteksi, antiulkus, dan antioksidan. Salah satu penyebab  kerusakan gaster adalah akibat paparan formalin merupakan iritatif karsinogenik sering disalahgunakan sebagai pengawet makanan. berpotensi mencegah disebabkan oleh formalin. Tujuan: Mengetahui pengaruh pemberian ekstrak daun kelor ( Moringa oleifera ) dosis bertingkat pada gambaran histopatologis mukosa tikus wistar dinduksi Metode: Jenis penelitian ini true...

Background: Burn injuries remain the third cause of death in world. The treatment, management deep dermal burns is by applying topical medications like nanosilver collagen cream. Collagen widely used for wound healing, cell development, angiogenesis, and platelets' activation. This study observed effectiveness drug administration cream compared to silver sulfadiazine against healing reviewed based on neutrophils counts angiogenesis.Methods: represents an experimental a laboratory with...

The incidence of anemia in Semarang was constantly increasing years by years. promotive and preventive activities through counseling were essential to increase the knowledge pregnant women for reducing anemia. Given fact that one-to-one using pamphlet rarely implemented, so this research about method needs be done. aim are determine difference between participant's pre post-intervention correlation among age, education, occupation, income, history (confounding variables) with knowledge....

Introduction: The soursoup leaves extract (Annona muricata) has widely been used as traditional medicine for cancer. No studies have conduct to investigate the safety of extract. Objectives: purpose study was acute oral toxicity test on Swiss mice’s liver and kidney.Methods: Twenty four mice were divided into 4 groups. Group I control group, while group II-IV given single dose orally via sonde. obsereved until day 7 determine LD50 at end terminated collect kidney. organs later made...

Introduction: Wounds fatality is possible on instances where treatment not conducted correctly. Moreover, Aloe Vera possesses anti-microbial activities, while ozone has bactericidal and antioxidant effects. This study is, therefore, aimed at assessing the number of neutrophils diameter full-thickness wounds, following multilevel dose administration ozonated aloe vera oil.Methods: an experimental study, based a post-test only control group design, with groups. A total 50 Sprague Dawley rats...

BACKGROUND Urinary tract infection (UTI) is a common source of bacteriemia. The most cause UTI Escherichia coli (E. coli). Tumor Necrosis Factor (TNF)-a gene polymorphism has been reported to be responsible for an excessive production TNF-a and eventual disruption pro-inflammatory cytokine regulation. aim this study was compare serum levels allele polymorphisms in patients with due E.coli non- controls. METHODS A cross-sectional conducted at Dr. Kariadi Central Hospital the Center Biomedical...

Background: Mosquito repellent technology has changed from conventional to electric technology, which is more secure and practical. All insect contains chemical compounds that can endanger health. D-Allethrin, the first pyrethroid generation of mosquito used commercially. Some studies in multi-ethnic population found transplacental transmission pregnancy. Objective: This study aims evaluate influences D-Allethrin on liver kidney, teratogenic effects foetal mice. Methods: An experimental...