A5031747809- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
- Gut microbiota and health
- Sphingolipid Metabolism and Signaling
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Probiotics and Fermented Foods
- Neonatal Respiratory Health Research
- Sirtuins and Resveratrol in Medicine
- Melanoma and MAPK Pathways
- Peroxisome Proliferator-Activated Receptors
- Gastrointestinal motility and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Effects of Radiation Exposure
- Infant Nutrition and Health
- S100 Proteins and Annexins
Sichuan University
2018-2024
Soochow University
2024
The First People’s Hospital of Lianyungang
2024
Nanjing Medical University
2024
Second Affiliated Hospital of Soochow University
2024
West China Hospital of Sichuan University
2024
Ningxia Medical University
2024
Harrison International Peace Hospital
2024
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
This study aimed to demonstrate whether exposure bifidobacteria during early life influences immunity and alleviates the risk of immunoglobulin E (IgE)-mediated allergies in adulthood. BALB/c neonatal mice (n=54) were administered with a lyophilised cell preparation Bifidobacterium bifidum TMC3115 (TMC3115) for 3 weeks. Following intervention, immunised intraperitoneal ovalbumin (OVA). The morphology function intestinal epithelium determined using histopathological examinations. Intestinal...
Accumulating evidence have shown that the intestinal microbiota plays an important role in prevention of host obesity and metabolism disorders. Recent studies also demonstrate early life is key time for colonization microbes host. However, there are few focusing on possible association between adulthood. Therefore present study was conducted to examine whether short term antibiotic and/or probiotic exposure could affect their long effects metabolism.A high-fat diet resulted glucose lipid...
e15111 Background: Mitogen-activated protein kinase (MAPK) pathway is a key regulator of cellular proliferation and survival, it highly correlated with the occurrence many cancers, JSI-1187 potent reversible small molecule inhibitor ERK1/2. This study designed to assess safety efficacy ERK Inhibitor for advanced MAPK-mutant tumors patients. Methods: phase 1 included dose escalation expansion (NCT06239623). The was conducted using 3+3 design 16, 24, 32, 48,72, 80 96 mg BID, 80, 128 152mg QD,...
High glucose (HG) induced endothelial senescence is related to dysfunction and cardiovascular complications in diabetic patients. Humanin, a member of mitochondrial derived peptides (MDPs), thought contribute aging-related protection. The goal the study explore pathogenesis HG-induced potential anti-senescent effects Humanin. Human umbilical vein cells (HUVECs) were exposed induce senescence, determined by β-galactosidase staining expressions p21, p53, p16. A clinically relevant dose HG (15...