A5032582694- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Mechanical Circulatory Support Devices
- Viral Infections and Immunology Research
- Metabolism, Diabetes, and Cancer
- Coronary Interventions and Diagnostics
- Adenosine and Purinergic Signaling
- Cardiovascular Function and Risk Factors
- PI3K/AKT/mTOR signaling in cancer
- Parasitic Infections and Diagnostics
- Ultrasound and Hyperthermia Applications
- Sports injuries and prevention
- Cardiovascular Issues in Pregnancy
- Regulation of Appetite and Obesity
- Cardiac Valve Diseases and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Organ and Tissue Transplantation Research
- Cardiovascular Disease and Adiposity
- Amoebic Infections and Treatments
Harefield Hospital
2023-2024
University of Messina
2021-2024
Royal Brompton & Harefield NHS Foundation Trust
2024
Humanitas Gavazzeni
2024
Guy's and St Thomas' NHS Foundation Trust
2023
University of Pisa
2020
Magna Graecia University
2005-2011
Interleukin 6 (IL-6) is an independent predictor of type 2 diabetes and cardiovascular disease correlated with insulin resistance. Insulin stimulates nitric oxide (NO) production through the IRS-1/PI3-kinase/Akt/eNOS pathway (where IRS-1 receptor substrate 1, PI3-kinase phosphatidylinositol 3-kinase, eNOS endothelial NO synthase). We asked if IL-6 affects vasodilator action both in human umbilical vein cells (HUVEC) aortas C57BL/6J mice whether this inhibitory effect was caused by increased...
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic and associated with insulin resistance cardiovascular disease. Among potential factors that may account for increased cardiometabolic risk, IGF-I a plausible candidate because main site its production. Our objective was to examine relationship between NAFLD levels test hypothesis free acids-induced might impair insulin-induced increase GH receptor (GHR) expression in human hepatoma cells. Five hundred three...
OBJECTIVE—The C-174G promoter polymorphism of the interleukin (IL)-6 gene was found to influence transcriptional activity and plasma IL-6 levels in humans. We addressed question whether contributes variation insulin sensitivity. RESEARCH DESIGN AND METHODS—Two cohorts subjects were genotyped. Cohort 1 includes 275 nondiabetic who underwent a euglycemic-hyperinsulinemic clamp. 2 77 patients with morbid obesity laparoscopic adjustable gastric banding (LAGB). RESULTS—The genotypes consistent...
The AMP-activated protein kinase (AMPK) lies upstream of Akt in the pathway leading to endothelial NO synthase (eNOS) activation. Whether leptin promotes eNOS activation via AMPK-dependent Akt, and which two AMPKα catalytic subunits is involved, remains unknown. Leptin resistance may be partly attributed interaction between C-reactive (CRP). We hypothesized that effect on human aortic cells might blunted by direct with recombinant CRP. Small interfering RNAs (siRNAs) were used knock down...
Abstract The use of left ventricular assist devices (LVAD) has significantly increased in the last years, trying to offer a therapeutic alternative heart transplantation, light also significant donor shortage compared growing advanced failure population. Despite technological improvements devices, LVAD-related mortality is still fairly high, with right being one predominant predictors. Therefore, many efforts have been made toward thorough (RV) evaluation prior LVAD implant, considering...
Myocardial infarction with non-obstructive coronary arteries (MINOCA) defines a heterogeneous group of atherosclerotic and non-atherosclerotic conditions, causing myocardial injury in the absence obstructive artery disease. Unveiling mechanisms subtended to acute event is often challenging; multimodality imaging approach helpful aid diagnosis. Invasive intravascular ultrasound or optical coherence tomography should be used, when available, during index angiography detect plaque disruption...
Background: Canine primary chronic enteropathy (CE) includes a heterogeneous group of diseases characterized by gastrointestinal signs.Aim: This study evaluated the occurrence Giardia duodenalis infection in CE-affected dogs.Methods: Forty-seven dogs different age and sex were enrolled study. For each dog, frequency defecation, fecal consistency, eventual abnormalities evaluated. A clinical scoring index CE severity (clinical activity index) was also assessed, type retrospectively...
Background: Cardiac allograft vasculopathy (CAV) is a rapidly progressive form of coronary atherosclerosis limiting long-term survival after heart transplantation. Objectives: We evaluated the diagnostic and prognostic yield quantitative stress cardiovascular magnetic resonance (CMR) perfusion for CAV detection in transplant recipients. Methods: Patients who received orthotopic transplants underwent CMR assessment were included study followed up almost 2 years (median 1.8; IQR 0.9,2.7). The...
Pandemie v podobně onemocnění COVID-19 rychle změnila klinický obraz světa. Symptomy se často dostavují plíživě a maskují dramatické klinické scénáře. Na oddělení akutního příjmu byl dopraven 52letý muž s perzistentní bolestí na hrudi, dyspnoe hypoxií. Stěžoval si rovněž kašel horečku (38 °C) přetrvávající už čtyři dny bez jakéhokoli klinického zlepšení při užívání paracetamolu. Nazofaryngeální stěr pozitivní přítomnost viru SARS-CoV-2. Vyšetření výpočetní tomografií vysokým rozlišením...
Abstract Aims Takotsubo syndrome (TTS) is an acute stress-induced cardiomyopathy showing left ventricular (LV) dysfunction without obstructive coronary arteries disease. A sudden massive surge of circulatory catecholamines from intense physical or emotional stress may play a central role in the pathogenesis TTS. We report case 87 years-old woman who developed TTS with uncommon presentation after permanent pacemaker (PM) implantation. Methods and results The patient was referred to our...
Background: Stress perfusion cardiac magnetic resonance (CMR) imaging is recommended in international guidelines class I patients with known or suspected CAD. Patients undergoing transplantation (OHT) are at risk of developing allograft vasculopathy (CAV). Adenosine relatively contraindicated after because a presumed atrioventricular block denervated hearts. We sought to evaluate the safety and feasibility adenosine stress CMR OHT CAV. Methods: In an outpatient cohort study, we measured...
This case, illustrating 12-years natural history of biventricular ACM, demonstrated the key role CMR as non-1 invasive imaging modality in identification pathognomonic features and dynamic changes phenotypical 2 expression this complex disease.3 4
Abstract Background During the last years, left atrial (LA) strain by speckle tracking echocardiography (STE) is gaining increasing evidence as diagnostic and prognostic tool in several clinical settings. However, lack of a dedicated software was considered one its main limitations, despite proven good feasibility reproducibility ventricular-based software. Importantly, brand-new fully automated tools to atrium have been developed, both for on-line measurement on echocardiographic machine...
Abstract Hypertrophic cardiomyopathy (HCM) is a muscle disorder with impairment of microvascular circulation. Intramyocardial hemorrhage (IMH) represents possible complication in patients myocardial infarction (MI) involving left ventricular (LV) tissue and micro vascularization. We describe case HCM patient anterior STEMI evidence IMH. Case Report A 61-years-old male from Sri Lanka no prior medical history presented to the emergency Department persistent chest pain started 3 hours. He was...