A5000278865- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Inflammatory Bowel Disease
- Chronic Lymphocytic Leukemia Research
- Phagocytosis and Immune Regulation
- Microscopic Colitis
- Digestive system and related health
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Abdominal vascular conditions and treatments
- Neutropenia and Cancer Infections
- Wnt/β-catenin signaling in development and cancer
- Genetic and Kidney Cyst Diseases
- Radiomics and Machine Learning in Medical Imaging
- Medical and Agricultural Research Studies
- Cardiac Arrest and Resuscitation
- Intestinal and Peritoneal Adhesions
- Ginkgo biloba and Cashew Applications
- Mechanical Circulatory Support Devices
- PI3K/AKT/mTOR signaling in cancer
- Innovations in Medical Education
- Health Sciences Research and Education
- Synthesis and biological activity
- Protein Tyrosine Phosphatases
Bạch Mai Hospital
2025
Helsinki University Hospital
2025
University of Helsinki
2025
Johns Hopkins University
1998-2024
Johns Hopkins Medicine
2012-2024
108 Military Central Hospital
2024
Medical College of Wisconsin
2020-2023
University of Colorado Denver
2023
University of Colorado Anschutz Medical Campus
2023
Hanoi University of Science and Technology
2022
Head and neck cancer (HNC) is the seventh most common worldwide, with a 5-year overall survival of 50–60%. Despite known factors, unexpected deaths underscore need to refine pre-treatment predictions. This study aimed identify novel data-driven HNC patient phenotypes, associated features predict using deep clustering model VaDeSC. We used retrospective cohort 1341 patients from Helsinki University Hospital, utilizing their clinical demographic data electronic health records. identified six...
The purpose of this study was to evaluate the clinical efficacy ultrasmall superparamagnetic iron oxide particles as a magnetic resonance (MR) contrast agent in differentiating metastatic from benign lymph nodes. Eighteen patients with primary lung malignancy and suspected regional node metastases underwent MR imaging before after Combidex(R) infusion multi-institutional study. All sequences were interpreted by one or more board-certified radiologists experienced thoracic malignancy. Each...
Abstract The Wnt/ß-catenin pathway is a critical stem cell regulator and plays important roles in neuroepithelial cells during early gestation. However, the role of signaling radial glia, major neural population expanded by midgestation, remains poorly understood. This study shows that genetic ablation ß-catenin with hGFAP-Cre mice inhibits neocortical formation disrupting glial development. Reduced glia intermediate progenitors are found ß-catenin-deficient neocortex late Increased...
Introduction: Approximately 20% of patients with ulcerative colitis (UC) experience an acute disease flare requiring hospitalization. Acute severe UC (ASUC) is a life-threatening condition that frequently requires intensive treatment steroids, electrolyte and fluid supplementation, nutritional support. Although steroids remain first line therapy, who fail to respond may require rescue therapy medications such as infliximab (IFX). In in whom medical fails, colectomy considered. Small studies...
Functional dyspepsia (FD) is a common disorder in clinical practice. It necessary to rule out physical causes diagnose this condition. However, the diagnosis challenging particularly resource-limited areas. The aim of consensus update international and regional guidelines on management FD. panel included 32 experts from major Vietnamese universities institutes. This study was conducted using Delphi method. grade recommendation level evidence were assessed Grading Recommendations, Assessment,...
Acute myeloid leukemia (AML) patients with the FMS‐related receptor tyrosine kinase 3 internal tandem duplication ( FLT3 /ITD) mutation have a poorer prognosis, and treatment inhibitors (TKIs) has been hindered by resistance mechanisms. One such mechanism is known as adaptive resistance, in which downstream signaling pathways are reactivated after initial inhibition. Past work shown that /ITD cells undergo through reactivation of extracellular signal‐regulated (ERK) within 24 h sustained We...
The cashew apple (Anacardium occidentale L.), is a pseudofruit that grows alongside the nut (true fruit) on tree. good source of nutrients and bioactive compounds. However, it highly perishable has an astringent, unpalatable taste, which limited utilisation apples in food industry. study focused evaluating impact various extraction methods (hydraulic pressing, screw blending) quality juice wine also aimed to compare effects using gelatin powder versus solution for astringent tannin removal....
Abstract In order to produce low-lactose dairy products the process of lactose hydrolysis is studied and optimal parameters depending on type enzyme samples are determined. By example two types enzymatic lactase (β-galactosidase): “Lacta-free” TM “Lactoferm ECO”, obtained from mushrooms Aspergillus oryzae, produced by Biochem srl. (Italy) “Maxilact-2000”, Kluyveromyces lactis yeast, “DSM Food Specialties” (Netherlands) most effective has been tested. Optimal for “Lacta-free”: at temperature...
INTRODUCTION: Histoplasma capsulatum is an environmental mold that typically causes mild, self-limited respiratory symptoms; in immunosuppressed patients more severe disseminated infection may occur. Symptoms of gastrointestinal (GI) histoplasmosis are nonspecific and can manifest many ways. CASE DESCRIPTION/METHODS: Case 1 80-year-old male with multiple myeloma status post auto-stem cell transplant 12 years prior, currently on lenalidomide. The patient presented 4-year history worsening...
Hairy roots are widely known as a biological system for the production of highly diverse biomolecules. β‐carotene – precursor vitamin A is to be an anti‐oxidant and anti‐gastric cancer protection agent against cardiovascular disease, heart disease stroke. has been chemically synthesised consumed by humans. However, chemical process often produces by‐product that may harmful human health. Therefore, this study established protocol induce hairy (HRs) from Vietnamese carrot variety produce...
Journal Article Hepatomegaly and multiple liver lesions Get access H C Chang, Chang Imaging Department, Johns Hopkins Bayview Medical Centre, University School, Baltimore, MD 21224-2780, USA Search for other works by this author on: Oxford Academic Google Scholar B Nguyen, Nguyen F Regan Correspondence to Dr Postgraduate Journal, Volume 74, Issue 873, July 1998, Pages 439–440, https://doi.org/10.1136/pgmj.74.873.439 Published: 01 1998 history Accepted: 21 January
Abstract Acute myeloid leukemia (AML) is a hematologic malignancy that characterized by increased myeloproliferation and block in differentiation of progenitor cells, leading to infiltration immature blasts the bone marrow peripheral blood. FMS-like tyrosine kinase-3 (FLT3) receptor kinase expressed hematopoietic cells. Approximately 30% AML cases harbor mutation FLT3 gene constitutive activation FLT3. The most commonly observed occurs juxtamembrane domain as an internal tandem duplication...
Background: DUX4 encodes a transcription factor that is active during early embryonic development.DUX4 gene fusions are seen in cancers, most often as CIC::DUX4 observed 95% of CIC-rearranged sarcomas.CIC-rearranged sarcoma rare undifferentiated small round cell occurs over wide age range, amongst children and young adults.Diagnosis best confirmed by molecular studies.DUX4 immunohistochemistry an increasingly utilized surrogate for fusions.Aim: To examine the utility performed clinical...