A5101810259- Adrenal Hormones and Disorders
- Stress Responses and Cortisol
- Biochemical and Molecular Research
- Hormonal Regulation and Hypertension
- Renal cell carcinoma treatment
- Vitamin D Research Studies
- Sex and Gender in Healthcare
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- Papaya Research and Applications
- Exercise and Physiological Responses
- Biochemical effects in animals
- Pneumonia and Respiratory Infections
- Advanced NMR Techniques and Applications
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Insect Resistance and Genetics
- Acute Myeloid Leukemia Research
- HIV/AIDS drug development and treatment
- Microbial infections and disease research
- Respiratory viral infections research
- Estrogen and related hormone effects
- Chemical Thermodynamics and Molecular Structure
- Adipose Tissue and Metabolism
- Cancer Mechanisms and Therapy
Augusta University
2019-2024
Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but chronic senescence, as in aging, can contribute to the development of age-related tissue dysfunction and disease. Previous studies clearly show removal senescent help extend healthspan during aging. increases with age skeletal system, selective depletion or inhibition their senescence-associated secretory phenotype (SASP) has been reported maintain improve bone mass aged mice. This suggests promoting...
Hyaluronic acid (HA) promotes cancer metastasis; however, the currently approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable disease. Sorafenib (SF) a modestly effective antiangiogenic drug for mRCC. Although only endothelial cells express known SF targets, cytotoxic to RCC at concentrations higher than pharmacological-dose (5-µM). Using patient cohorts, mRCC models, and combination with 4-methylumbelliferone (MU), we discovered in targeted it treatment.We...
Excess fat within bone marrow is associated with lower density. Metabolic stressors such as chronic caloric restriction (CR) can exacerbate adiposity, and increased glucocorticoid signaling adrenergic are implicated in this phenotype. The current study tested the role of CR-induced stress by conditionally deleting receptor (GR) osteoprogenitors (Osx1-Cre) mice subjected to CR ad libitum diets. Conditional knockout GR (GR-CKO) reduced cortical trabecular mass compared wildtype (WT) under both...
ABSTRACT Hallmarks of aging-associated osteoporosis include bone loss, marrow adipose tissue (BMAT) expansion, and impaired osteoblast function. Endogenous glucocorticoid levels increase with age, elevated signaling, associated chronic stress dysregulated metabolism, can have a deleterious effect on mass. Canonical signaling through the receptor (GR) was recently investigated as mediator during caloric restriction. To address role GR in an osteoporotic phenotype, current study utilized...
The paucity of preclinical models that recapitulate COVID-19 pathology without requiring SARS-COV-2 adaptation and humanized/transgenic mice limits research into new therapeutics against the frequently emerging variants-of-concern. We developed virus-free by C57BL/6 receiving oropharyngeal instillations a ribo-oligonucleotide common in all variants or specific to Delta/Omicron variants, concurrently with low-dose bleomycin. Mice COVID-19-like lung pathologies including ground-glass...
In the quest for improving clinical outcome of patients with metastatic genitourinary cancers, including renal cell carcinoma (mRCC), emphasis often is on finding new targeted therapies. However, two studies by Jordan et al. (Oncogenesis 2020) and Wang (Cancer Cell Int 2022) demonstrate feasibility efficacy a modestly effective drug Sorafenib against mRCC attacking mechanism hijacked RCC cells inactivating Sorafenib. The also identified hyaluronic acid synthase -3 (HAS3) as bonafide target...