A5046746033- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Dermatological and Skeletal Disorders
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Parkinson's Disease and Spinal Disorders
- Parathyroid Disorders and Treatments
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Eosinophilic Disorders and Syndromes
- Caveolin-1 and cellular processes
- Autoimmune Neurological Disorders and Treatments
- Galectins and Cancer Biology
- Microtubule and mitosis dynamics
- Pain Mechanisms and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Antifungal resistance and susceptibility
- Cardiac Arrest and Resuscitation
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
- Cancer Treatment and Pharmacology
University of Calgary
2015-2025
Deleted Institution
2021-2023
Universität Hamburg
2023
South Health Campus
2020-2022
Libin Cardiovascular Institute of Alberta
2022
McGill University
2022
Centre National pour la Recherche Scientifique et Technique (CNRST)
2021
Alberta Health Services
2021
Foothills Medical Centre
2020
Canadian Sleep Society
2020
The RNA-binding proteins LIN28A and LIN28B have diverse functions in embryonic stem cells, cellular reprogramming, growth, oncogenesis. Many of these effects occur via direct inhibition Let-7 microRNAs (miRNAs), although Let-7-independent been surmised. We report that intestine targeted expression causes intestinal hypertrophy, crypt expansion, Paneth cell loss. Furthermore, fosters polyp adenocarcinoma formation. To examine potential LIN28B, we pursued ribonucleoprotein cross-linking,...
Pancreatic exocrine cell plasticity can be observed during development, pancreatitis with subsequent regeneration, and also transformation. For example, acinar–ductal metaplasia (ADM) occurs acute might viewed as a prelude to pancreatic intraepithelial neoplasia (PanIN) ductal adenocarcinoma (PDAC) development. To elucidate regulatory processes that overlap ADM, the progression of normal cells PanIN lesions, we undertook systematic approach identify Prrx1 paired homeodomain transcriptional...
Igf2 mRNA binding protein 1 (IMP1, CRD-BP, ZBP-1) is a messenger RNA that we have shown previously to regulate colorectal cancer (CRC) cell growth in vitro . Furthermore, increased IMP1 expression correlates with enhanced metastasis and poor prognosis CRC patients. In the current study, sought elucidate IMP1-mediated functions pathogenesis vivo Using xenografts, demonstrate overexpression promotes xenograft tumor dissemination into blood. intestine-specific knockdown of Imp1 dramatically...
Objectives Patients commonly come to the emergency department (ED) with social needs. To address this, we created Highland Health Advocates (HHA), an ED-based help desk and medical-legal partnership using undergraduate volunteers patients navigate public resources provide onsite legal work referrals. We were able these services in English Spanish. aimed determine needs of who presented our ED potential impact programme resolving those connecting them a ‘medical home’ (defined as consistent,...
Wild-type transthyretin amyloidosis (wtATTR) is an important cause of heart failure (HF); however, the prevalence and clinical significance neurologic complications remains uncertain.This analysis reports findings from a single-centre experience routine neuropathy screening at time wtATTR diagnosis by nerve conduction studies neurologist assessment, compared with age-matched controls.Forty-one patients were included, 39 (95%) males, mean age 78.4 ± 7.7 years, 22 (54%) New York Heart...
Survival rates after out-of-hospital-cardiac-arrest (OHCA) differ widely between EMS systems. Since hypertonic saline appears to improve long-term outcome OHCA, some local systems have included it in their treatment protocols for OHCA. Our first aim was give a quality review of one these protocols. second assess whether short-term survival improves when is used resuscitation OHCA.Matched pairs were identified the independent "return spontaneous circulation (ROSC) cardiac arrest" (RACA) score...
Abstract Many motile bacteria exhibit chemotaxis, the ability to bias their random motion ward or away from increasing concentrations of chemical substances which benefit inhibit survival, respectively. Since encounter numerous concentration gradients simulatneously in natural surroundings, it is necessary know quantitatively how a bacterial population responds presence more than one stimulus develop predictive mathematical models describing migration systems. This work evaluates three...
Up to 25% of patients with myasthenia gravis (MG) have refractory disease despite trials multiple immunosuppressants. Several case series describe acetylcholine receptor antibody-positive (AChR) MG treated autologous hematopoietic stem cell transplant (HSCT). In this report, we three anti-muscle-specific kinase (MuSK) HSCT.We included all who had undergone HSCT anti-MuSK identified through the records Alberta Blood and Marrow Transplant Program. We collected demographic clinical data...
Background: Carpal tunnel syndrome (CTS) is common in patients with transthyretin amyloidosis (ATTR), and many experience residual symptoms and/or develop recurrent disease following routine carpal release (CTR). An extended CTR median nerve neurolysis recommended for thorough decompression. Tissue confirmation of can be performed at the time biopsies transverse ligament tenosynovium. Methods: We describe a retrospective, single-center performing an technique including unilateral bilateral...
ABSTRACT: Background: Flow cytometry of the cerebrospinal fluid (CSF) is used in isolation or as an adjunct to cytology increase sensitivity detecting central nervous system (CNS) lymphoma. We aimed evaluate CSF flow a diagnostic screening tool for primary CNS lymphoma patients presenting with undifferentiated neurologic symptoms. Methods: retrospectively reviewed all samples received by Calgary Laboratory Services Cytometry from 2012 2015. Clinical data, laboratory investigations,...
Abstract Background: Patients with acute cardio-embolic stroke from atrial fibrillation (AF) are at risk for recurrence up to 50% of recurrent occurring within two weeks the index event. Anti-coagulation heparinoids 48 hours has been shown increase symptomatic intracranial hemorrhage (ICH) no clear benefit on early recurrence. Methods : This study was a retrospective chart review consecutive patients who were admitted service Foothills Medical Centre between 2009 and 2011. All an etiology...
Abstract Background Hereditary transthyretin amyloidosis is an uncommon multisystem disorder caused by mutation of the protein, leading to peripheral neuropathy often with autonomic features, cardiomyopathy, or a mixed phenotype. Multiple other organ systems can be involved ophthalmologic, renal, hematologic, gastrointestinal, and/or genitourinary symptoms and signs. This results in assessments multiple specialists significant delays before diagnosis recognized. With recent advent...
Ultrasound-guided nerve blocks are quickly becoming integrated into emergency medicine practice for pain control and as an alternative to procedural sedation. Common, but potentially catastophic errors have not been reported outside of the anesthesiology literature. Evaluation brachial plexus with color Doppler should be standard clinicians performing a supraclavicular block determine ideal location prevention inadvertant intravascular injection. [West J Emerg Med. 2014;15(6):-0]
Alberta is a Canadian province with high prevalence of multiple sclerosis (MS). In this ecological study, we examined group differences in health care utilization among persons MS (pwMS) living within different regions the province.pwMS were identified from provincial administrative databases spanning 2002-2011. Utilization services was determined for 2-year period (April 2010-March 2012). Residential postal codes placed patients into their zones. As data provided to investigators an...
Hepatic portal venous gas (HPVG) has long been associated with catastrophic intraabdominal conditions. Advancements in ultrasound (US) and computed tomography (CT) imaging have resulted an increased number of incidental clinically benign HPVG cases identified. Causes include viral gastroenteritis, gastritis, pancreatitis, appendicitis diverticulitis. Our case demonstrates the first reported adolescent patient enteropathogenic E. coli (EPEC). The patient's course was favorable, marked by a...