A5063187344- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Fatty Acid Research and Health
- Pancreatitis Pathology and Treatment
- Ferroptosis and cancer prognosis
- Hypothalamic control of reproductive hormones
- Diabetes Treatment and Management
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Coagulation and Thrombosis Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiovascular Disease and Adiposity
- Birth, Development, and Health
- Hormonal and reproductive studies
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Prenatal Screening and Diagnostics
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
University of Bari Aldo Moro
2021-2023
University of Naples Federico II
2006
Diabetes mellitus is a chronic metabolic disease, the prevalence of which constantly increasing worldwide. It often burdened by disabling comorbidities that reduce quality and expectancy life affected individuals. The traditional complications diabetes are generally described as macrovascular (e.g., coronary heart peripheral arterial stroke), microvascular diabetic kidney retinopathy, neuropathy). Recently, due to advances in management increased patients, strong correlation between other...
Targeted drug delivery to pancreatic beta-cells could represent a promising therapeutic option for the treatment of type 2 diabetes (T2D), as it can improve efficacy and reduce required doses side effects. We will discuss strategies target T2D, describing possibility inducing expression specifically in beta-cells, available carriers, peptides that be used active targeting, most suitable routes administration direct beta-cells.
We evaluated the role of p66Shc redox adaptor protein in pancreatic β-cell insulin resistance that develops under lipotoxic conditions and with excess body fat. Prolonged exposure to palmitate vitro or presence overweight/obesity augmented expression levels caused an impaired ability exogenous increase cellular content secreted C-peptide INS-1E cells human murine islets. In cells, knockdown resulted enhanced insulin-induced augmentation secretion prevented impair these effects insulin....
Irisin is a hormone secreted by skeletal muscle following physical activity or excess of saturated fatty acids, able to promote energy expenditure and improve metabolic homeostasis. Serum irisin levels are reduced in type 2 diabetes (T2D), while exogenous administration improves glycemic control diabetic mice. We have previously demonstrated that promotes beta-cell viability insulin secretory function. This study investigated serum T2D patients according their antidiabetes treatment. 127...
Aim: Irisin is a hormone secreted by skeletal muscle able to improve metabolic homeostasis. Serum irisin levels are reduced in type 2 diabetes (T2D), while exogenous administration improves glycemic control diabetic mice. We have previously demonstrated that promotes beta-cell survival and function both vitro vivo healthy wild also restores the defective glucose-stimulated insulin secretion (GSIS) reduces apoptosis human pancreatic islets from patients with T2D. Nevertheless, beta-cellular...