A5079290034- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- Microbial Metabolic Engineering and Bioproduction
- RNA Research and Splicing
- Advancements in PLL and VCO Technologies
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Biofuel production and bioconversion
- Electronic Packaging and Soldering Technologies
- Internet Traffic Analysis and Secure E-voting
- Surface and Thin Film Phenomena
- Galectins and Cancer Biology
- Chromosomal and Genetic Variations
- Distributed systems and fault tolerance
- Blockchain Technology Applications and Security
- Protein Degradation and Inhibitors
- Radio Astronomy Observations and Technology
- Security and Verification in Computing
- Algorithms and Data Compression
- Geomagnetism and Paleomagnetism Studies
- Fault Detection and Control Systems
- Kruppel-like factors research
- Cryptography and Data Security
Institute of Information Security
2023
University of Stuttgart
2022-2023
Max Planck Institute for Dynamics of Complex Technical Systems
2022-2023
Universitätsmedizin Greifswald
2021-2022
Jena University Hospital
2020
TU Bergakademie Freiberg
2020
Heidelberg University
2017
Medizinische Hochschule Hannover
2016
University of Sussex
2005-2011
The development of monitoring systems for rotating machines is the ability to accurately detect different faults in an incipient state. most popular machine industry squirrel-cage induction motor, and failure on such motors may have severe consequences costs, product quality, safety. Most condition-monitoring techniques focus a single specific fault. identification two or more combined has been rarely considered, spite being very usual situation real rotary machines. On other hand,...
PMM2-CDG, formerly known as congenital disorder of glycosylation-Ia (CDG-Ia), is caused by mutations in the gene encoding phosphomannomutase 2 (PMM2). This disease most frequent form inherited CDG-diseases affecting protein N-glycosylation human. PMM2-CDG a multisystemic with severe psychomotor and mental retardation. In order to study pathophysiology human cell culture model, we generated induced pluripotent stem cells (iPSCs) from fibroblasts PMM2-CDG-patient (PMM2-iPSCs). Expression...
Abstract Persistence of malignant clones is a major determinant adverse outcome in patients with hematologic malignancies. Despite the fact that majority acute myeloid leukemia (AML) achieve complete remission after chemotherapy, large proportion them relapse as result residual cells. These persistent have competitive advantage and can re-establish disease. Therefore, targeting strategies specifically diminish cell competition cells while leaving normal unaffected are clearly warranted....
Elections are an important corner stone of democratic processes. In addition to publishing the final result (e.g., overall winner), elections typically publish full tally consisting all (aggregated) individual votes. This causes several issues, including loss privacy for both voters and election candidates as well so-called Italian attacks that allow easily coercing voters.
In the liver tumor necrosis factor (TNF)-induced signaling critically regulates immune response of non-parenchymal cells as well proliferation and apoptosis hepatocytes via activation NF-κB JNK pathways. Especially, induction negative feedback regulators such IκBα A20 is responsible for dynamic time-restricted these important However, precise mechanisms different TNF-induced phenotypes under physiological stimulation conditions are not completely understood so far. addition, it known if...
Abstract Mutations of the JAK2 gene are frequent aberrations in aging hematopoietic system and myeloid neoplasms. While JAK-inhibitors efficiently reduce hyperinflammation induced by constitutively active mutated kinase, malignant clone abundance cells remains rather unaffected. Here, we sought to assess for genetic vulnerabilities JAK2-mutated clones. We identified lysine-specific demethylase KDM4C as a selective dependency that persists upon JAK-inhibitor treatment. Genetic inactivation...
In this article we describe a novel design of the fixed-length, one-bit autocorrelation function (ACF) using Spartan XC2S300 field programmable gate array (FPGA). It has been implemented both asynchronously and synchronously following same underlying architectural concept. Although some problems arose in asynchronous case due to nature design, these were overcome with synchronous architecture. With new method there ninefold reduction terms FPGA active area usage for implementation algorithm...
Cell-free production systems are increasingly used for the synthesis of industrially relevant chemicals and biopharmaceuticals. often utilize cell lysates, but biocatalytic cascades based on recombinant enzymes have emerged as a promising alternative strategy. However, implementing efficient enzyme is non-trivial task mathematical modeling optimization has become key tool to improve their performance. In this work, we introduce generic framework model-based cell-free given kinetic model...
Safety-critical digital systems such as Fly-by-wire control have demanding integrity and availability requirements which significantly exceed the occurrence rates of random hardware faults observed in computers. As a result, system designers need to employ reliable fault detection mitigation techniques. Until now, only method achieve sufficiently for that can cause hazardous or catastrophic events, is replicate computer lanes detect by comparing outputs. However, this comes with large...
Cell-free biosynthesis uses the machinery of cells, such as metabolic reactions, to carry out conversion processes in vitro. This can be more beneficial than vivo approaches like fermentations. Some advantages these synthetic biology include higher product yields, rates and titers, flexibility pathway design. is still early stages and, unlike production, there are very few examples model-based optimization. Moreover, we encounter static optimizations most cases, neglecting dynamic nature...