A5064770427- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Healthcare and Venom Research
- Ion channel regulation and function
- Insect and Pesticide Research
University of Utah
2020-2024
University of the Philippines Diliman
2020
The venom of cone snails has been proven to be a rich source bioactive peptides that target variety ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) are powerful tools for investigating the structure function various nAChR subtypes. By studying how conotoxins nAChRs, we can improve our understanding these receptors, leading new insights into neurological diseases associated nAChRs. Here, describe discovery characterization novel...
The cone snails (family Conidae) are the best known and most intensively studied venomous marine gastropods. However, of total biodiversity mollusks (superfamily Conoidea, >20,000 species), comprise a minor fraction. venoms family Drilliidae, highly diversified in have not previously been investigated. In this report, we provide first biochemical characterization component Drilliidae venom define gene superfamily peptides. A bioactive peptide, cdg14a, was purified from Clavus davidgilmouri...