A5059856801- Constructed Wetlands for Wastewater Treatment
- interferon and immune responses
- Coastal wetland ecosystem dynamics
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Bacterial Genetics and Biotechnology
- Polydiacetylene-based materials and applications
- Silkworms and Sericulture Research
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Lipid Membrane Structure and Behavior
- Eosinophilic Esophagitis
- Chemical Synthesis and Analysis
- Biological Control of Invasive Species
- Geochemistry and Elemental Analysis
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Circular RNAs in diseases
- Advanced Chemical Sensor Technologies
- Genomics and Chromatin Dynamics
- SARS-CoV-2 detection and testing
- Retinoids in leukemia and cellular processes
- Biosensors and Analytical Detection
- Phosphorus and nutrient management
- Fungal Biology and Applications
Sri Lanka Institute of Information Technology
2023-2025
CRUK Lung Cancer Centre of Excellence
2020-2022
University College London
2020-2022
London Cancer
2021
University of Sheffield
2011-2015
University of Moratuwa
2004-2009
Summary In Bacillus subtilis , EzrA is involved in preventing aberrant formation of FtsZ rings and has also been implicated the localization cycle Pbp1. We have identified orthologue Staphylococcus aureus to be essential for growth cell division this organism. Phenotypic analyses following titration levels S. shown that protein required peptidoglycan synthesis as well assembly divisome at midcell cytokinesis. Protein interaction studies revealed forms a complex with both cytoplasmic...
This paper elucidates the phytoremediation potential of water hyacinth (Eichhornia crassipes [Mart.] Solms) for TN and TP rich industrial wastewaters determined 15 weeks under different set-ups 2-fold (56 mg/l 15.4 mg/l), 1-fold, 1/2-fold, 1/4-fold 1/8-fold a control with no nutrients in duplicate. A mass balance was conducted to evaluate efficiencies identify key mechanisms nutrient removal from wastewaters. Our results manifested that is promising candidate batch 100% both observed at end...
All life demands the temporal and spatial control of essential biological functions. In bacteria, recent discovery coordinating elements provides a framework to begin explain cell growth division. Here we present supramolecular structure in membrane coccal bacterium Staphylococcus aureus, which leads formation large-scale pattern across entire body; this has been unveiled by studying distribution proteins involved lipid metabolism (PlsY CdsA). The organization is found require MreD,...
Abstract Innate lymphoid cells are central to the regulation of immunity at mucosal barrier sites, with group 2 innate (ILC2s) being particularly important in type immunity. In this study, we demonstrate that microRNA(miR)-142 plays a critical, cell-intrinsic role homeostasis and function ILC2s. Mice deficient for miR-142 expression an ILC2 progenitor–biased development bone marrow, along peripheral ILC2s these display greatly altered phenotype based on surface marker expression....
Abstract Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate histone H3.3 chaperone Daxx, a element repressor inactivated in myeloid leukaemia other neoplasms, protection from inflammatory disease. Loss Daxx alters chromatin landscape, distribution marks haematopoietic progenitors, leading engagement Pu.1-dependent transcriptional programme for...
AML is a genetically heterogeneous disease and understanding how different co-occurring mutations cooperate to drive leukemogenesis will be crucial for improving diagnostic therapeutic options patients. MIR142 have been recurrently detected in IDH-mutated samples. Here, we used mouse model investigate the interaction between these two demonstrate striking synergy Mir142 loss-of-function IDH2R140Q, with only recipients of double mutant cells succumbing leukemia. Transcriptomic analysis...
This article discusses key mechanisms involved in removing 1 mg/L Mn from synthetic wastewaters constructed wetlands comprising water hyacinth ( Eichhornia crassipes (Mart.) Solms) grown under different nutrient levels of 1‐fold (28 and 7.7 total nitrogen phosphorus, respectively), 2‐fold, 1/4‐fold, 1/8‐fold. A mass balance was carried out to evaluate the removal mechanisms. Phytoremediation mainly due phytoextraction substantially contributed manganese removal. However, chemical...
Abstract This article reports the phytoremediation efficiencies of water hyacinth (Eichhornia crassipes (Mart.) Solms) grown under different nutritional conditions for Al rich wastewaters in batch type constructed wetlands (floating aquatic macrophyte-based plant treatment systems). study was conducted 15 weeks after 1 week acclimatization by culturing young (average height 20 ± 2 cm) 590 L capacity fiberglass tanks nutrient concentrations 2-fold [56 and 15.4 mg/L total nitrogen (TN)...
This study investigated the development of aptamer-based molecular probes to detect Methicillin-Resistant Staphylococcus aureus (MRSA) and evaluated antibacterial activity. Early detection MRSA infection will improve patients’ recovery reduce cost for treating patients. S. can become resistant methicillin other β-lactam antibiotics through expression PBP2A protein, which is action methicillin. We have developed two aptamer against protein whole bacterial cell under optimized in vitro...
Anti biotic resistant bacteria have posed a serious threat to world health in recent years, forcing the investigation of alternate sources for anti bacterials. Higher plants are key source medicinal compounds. The objective this study was evaluate bacterial properties C. speciosus against gram-negative E. coli and gram-positive Staphylococcus aureus, explore its potential as natural alternative conventional bioti cs. Leaves, stems, rhizomes were extracted using hexane, methanol, water...
Fluoropyrimidine (FP) chemotherapy drug is utilized to treat colon, head, neck and breast cancers. Apart from its effectiveness, toxicity a limitation. DPD (dihydropyrimidine dehydrogenase) enzyme, which aids in the FP metabolism produced by highly polymorphic DPYD gene. Mutations gene cause deficiency or non-functionality of enzyme varies among different populations. This research aimed compare allele frequencies common variants South Asians (SAS) such as DPYD*2A(rs3918290),...
Gyrinops walla (G.walla), often referred to as ‘Walla Patta’ in Sinhala, is an indigenous, economically important plant renowned for its production of agarwood, which a highly valuable resin having high economical, religious and traditional values. G. trees take 5-7 years on average grow naturally before being inoculated produce resin. In-vitro callus culture approach will shorten the agarwood process significantly be industry. However, tissue methods are challenging due explant...
An amendment to this paper has been published and can be accessed via a link at the top of paper.