A5059894400- Plant tissue culture and regeneration
- Plant Molecular Biology Research
- Plant Reproductive Biology
- RNA regulation and disease
- Neurological Disorders and Treatments
- Neurology and Historical Studies
- Biotin and Related Studies
- Neuroscience and Neuropharmacology Research
- Fuel Cells and Related Materials
- Click Chemistry and Applications
- Various Chemistry Research Topics
- RNA and protein synthesis mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Molecular spectroscopy and chirality
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
Centre for Cellular and Molecular Biology
2024-2025
University College London
2018
Montreal Neurological Institute and Hospital
2018
Vita-Salute San Raffaele University
2018
Ghent University Hospital
2018
Abstract Long non-coding RNAs (lncRNAs) play a crucial role in fine-tuning the gene expression. In present study, we identified that lncRNA NEAT1 is upregulated failing murine hearts and human hypertrophic cardiomyopathies. Further investigations demonstrated expression regulated by calcium dependent NFAT (nuclear factor of activated T cells). Overexpression led to increased cardiomyocyte size elevated cardiac stress markers while its depletion had opposite effect. Through transcriptomic...
Abstract Refolding based Bimolecular Fluorescence Complementation (BiFC) has emerged as an important in vivo technique to identify protein interactions. Significant improvements have been made enhance the detection capacities of BiFC, however less attention paid expression levels proteins. Here we demonstrate development and validation improved method interactions that incorporates control on bicistronic interest a fluorescent separated by self-cleaving peptide. This gives robust...
Plants alternate between diploid sporophyte and haploid gametophyte generations. In mosses which retain features of ancestral land plants, the is dominant has an independent existence. However, in flowering plants undergone evolutionary reduction to just a few cells enclosed within sporophyte. The thought genetic control its development even after reduction. Here we demonstrate that male Arabidopsis, long considered be autonomous, also under We identify Arabidopsis gene SHUKR as inhibitor...
Homozygous LCDmut develop neurodegenerative phenotypes including a) decreased grip strength and b) muscle force, together with c) reduced number of surviving motor units d) positive p62 inclusions in the spinal cord Conclusion: Mutation-induced gain splicing function TDP43 is sufficient to cause neurodegeneration could constitute an early process pathophysiology ALS.