A5086412893- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Proteoglycans and glycosaminoglycans research
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Bamboo properties and applications
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Tree Root and Stability Studies
- Glioma Diagnosis and Treatment
- Tracheal and airway disorders
- Wood Treatment and Properties
University of California, Los Angeles
2022-2023
Pulmonary and Allergy Associates
2007
Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) patients. GBM cells aggressively invade parenchyma while encountering spatiotemporal changes their local ECM, including HA concentration. To investigate how varying concentrations affect invasion, patient-derived are cultured within soft, 3D which concentration is precisely varied and cell migration observed. Data...
Although many children with obstructive sleep apnea syndrome have complete resolution of after adenotonsillectomy, some patients persistent requiring positive airway pressure treatment. Little is known about adherence among school-aged and adolescents.We retrospectively reviewed records from January 2000 through December 2004 to assess following a comprehensive patient- parent-focused education program for 7 19 years age subsequent indicated adenotonsillectomy. A polysomnogram was obtained...
Cell-matrix interactions mediate complex physiological processes through biochemical, mechanical, and geometrical cues, influencing pathological changes therapeutic responses. Accounting for matrix effects earlier in the drug development pipeline is expected to increase likelihood of clinical success novel therapeutics. Biomaterial-based strategies recapitulating specific tissue microenvironments 3D cell culture exist but integrating these with 2D methods primarily used screening has been...
Direct-displacement seismic design assumes that the response of a structural system can be obtained through single-degree-of-freedom (SDOF) model with equivalent elastic lateral stiffness and viscous damping properties representative characteristics structure at target displacement. To date, this assumption has not been validated for structures exhibiting highly pinched hysteretic response, as is typical wood structures. This paper presents discusses results an extensive numerical...
Cell-matrix interactions mediate complex physiological processes through biochemical, mechanical, and geometrical cues, influencing pathological changes therapeutic responses. Accounting for matrix effects earlier in the drug development pipeline is expected to increase likelihood of clinical success novel therapeutics. Biomaterial-based strategies recapitulating specific tissue microenvironments 3D cell culture exist but integrating these with 2D methods primarily used screening has been...
Glioblastoma Tumors (GBM) tumors aggressively invade the brain and are highly lethal. Hyaluronic acid (HA), a polysaccharide ubiquitous in extracellular matrix, is overexpressed GBM tumors. Using patient-derived cells engineered, 3D culture microenvironments, article 2203143 by Stephanie K. Seidlits co-workers demonstrates biphasic relationship between invasive activity HA concentration that depends on phosphorylation of ezrin downstream CD44 receptor.