A5034383180- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Ferroptosis and cancer prognosis
- Economic, Social, and Health Studies
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
State Key Laboratory of Oncogene and Related Genes
2024
Abstract Background Immunotherapy has emerged as a potent clinical approach for cancer treatment, but only subsets of patients can benefit from it. Targeting lactate metabolism (LM) in tumor cells method to potentiate anti-tumor immune responses represents promising therapeutic strategy. Methods Public single-cell RNA-Seq (scRNA-seq) cohorts collected who received immunotherapy were systematically gathered and scrutinized delineate the association between LM response. A novel LM-related...
The resistance of tumors to immune checkpoint inhibitors (ICI) may be intricately linked cellular senescence, although definitive clinical validation remains elusive. In this study, comprehensive pan-cancer scRNA-seq analyses identify fibroblasts as exhibiting the most pronounced levels senescence among tumor-associated cell populations. To elucidate phenomenon, a fibroblast senescence-associated transcriptomic signature (FSS), which correlated strongly with protumorigenic signaling pathways...