A5068955139- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Gene expression and cancer classification
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
Johns Hopkins University
2023-2024
Cancer Research Center
2023-2024
Circulating carbohydrate antigen 19-9 (CA19-9) levels reflect FUT3 and FUT2 fucosyltransferase activity. Measuring the related glycan, DUPAN-2, can be useful in individuals unable to synthesize CA19-9. We hypothesized that similar CA19-9, FUT functional groups determined by variants
Abstract Purpose: CA19–9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT variants, evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC). Experimental Design: A representative set of controls from Cancer Pancreas Screening study was identified each functional group. Diagnostic sensitivity determined first testing 234 PDAC cases, followed 134-case validation set, all whom...
PURPOSE Inherited cancer susceptibility is often not suspected in the absence of a significant family history. Pathogenic germline variants pancreatic are well-studied, and routine genetic testing recommended guidelines. However, data on rare periampullary cancers other than insufficient. We compared prevalence patients with nonpancreatic cancers. MATERIALS AND METHODS Six hundred eight who had undergone pancreaticoduodenal resection at tertiary referral hospital were studied, including 213...
<p>Supplementary tables</p>
<p>Supplementary Figure 1</p>
<p>Supplementary Figure 2</p>
<p>Supplementary Figure 2</p>
<p>Supplementary tables</p>
<p>Supplementary Figure 1</p>
<div>Abstract<p>Purpose: CA19-9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC). Experimental Design: A representative set of controls from Cancer Pancreas Screening study was identified each functional group. Diagnostic sensitivity determined first testing 234 PDAC cases, followed 134-case validation set,...
<p>Supplementary tables</p>
<p>Supplementary Figure 2</p>
<p>Supplementary tables</p>
<div>Abstract<p>Purpose: CA19-9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC). Experimental Design: A representative set of controls from Cancer Pancreas Screening study was identified each functional group. Diagnostic sensitivity determined first testing 234 PDAC cases, followed 134-case validation set,...
<p>Supplementary Figure 1</p>
<p>Supplementary Figure 1</p>
<p>Supplementary Figure 2</p>
<div>AbstractPurpose:<p>CA19–9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT variants, evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC).</p>Experimental Design:<p>A representative set of controls from Cancer Pancreas Screening study was identified each functional group. Diagnostic sensitivity determined first testing 234 PDAC cases, followed...