A5078637908- Chronic Myeloid Leukemia Treatments
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Chronic Lymphocytic Leukemia Research
- Career Development and Diversity
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- Biomedical and Engineering Education
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Herpesvirus Infections and Treatments
- Higher Education and Employability
- Fungal Plant Pathogen Control
- Antibiotic Resistance in Bacteria
- Galectins and Cancer Biology
- Experimental Learning in Engineering
- DNA Repair Mechanisms
- Plant and Fungal Interactions Research
- Various Chemistry Research Topics
- Cancer-related gene regulation
- Bacterial Genetics and Biotechnology
University of Pittsburgh at Greensburg
2023-2025
California Northstate University
2025
University of Pittsburgh
2024
University of California, Berkeley
2024
Thiel College
2014-2022
National Institute of Environmental Health Sciences
2014
University Hospitals of Cleveland
2007-2011
Case Western Reserve University
2007-2011
Comprehensive Blood & Cancer Center
2008
U-M Rogel Cancer Center
2008
It is generally believed that shutting down the kinase activity of BCR-ABL by imatinib will completely inhibit its functions, leading to inactivation downstream signaling pathways and cure disease. Imatinib highly effective at treating human Philadelphia chromosome-positive (Ph(+)) chronic myeloid leukemia (CML) in phase but not Ph(+) B cell acute lymphoblastic (B-ALL) CML blast crisis. We find SRC kinases activated remain fully active imatinib-treated mouse leukemic cells, suggesting does...
Glucocorticoid hormones, including dexamethasone, induce apoptosis in lymphocytes and consequently are used clinically as chemotherapeutic agents many hematologic malignancies. Dexamethasone also induces autophagy lymphocytes, although the mechanism is not fully elucidated. Through gene expression analysis, we found that dexamethasone of a encoding stress response protein variously referred to Dig2, RTP801, or REDD1. This reported inhibit mammalian target rapamycin (mTOR) signaling. Because...
Glucocorticosteroid hormones, including prednisone and dexamethasone (Dex), have been used to treat lymphoid malignancies for many years because they readily induce apoptosis in immature lymphocytes lacking Bcl-2. However, elevated expression of the anti-apoptotic protein Bcl-2 inhibits contributes glucocorticoid resistance. Using Bcl-2-negative WEHI7.2 lymphoma line as an experimental model, we found that Dex not only induces but also autophagy. The caspase inhibitor Z-VAD-fmk inhibited...
A report on research that explicates three models of pedagogical practice underpin and characterize inquiry instruction in a course-based experience.
Alternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional translational interference results in isoform-dependent changes protein expression. Specifically, long undecoded (LUTI) is transcribed from gene-distal promoter, interfering with expression the gene-proximal promoter. Although chromatin features associated LUTI have been described, mechanism underlying LUTI-based...
Two bacteriophages, BeatusComedenti and Cyan, were isolated using Arthrobacter sp. globiformis , respectively. which contain 100 70 putative genes, are assigned to actinobacteriophage clusters AT AZ1,
e18531 Background: Ponatinib has been well studied in treating Chronic Myeloid Leukemia. However, there are no reviews to date analyzing the efficacy of ponatinib Ph+ Acute Lymphoblastic Leukemia (ALL). is a 3rd generation, broad-spectrum tyrosine kinase inhibitor (TKI) designed suppress mutations conferring resistance earlier generations TKIs including threonine isoleucine mutation at position 315 (T315I) BCR-ABL fusion protein. We aim review clinical studies evaluating ALL populations....
Bacteria in the Arthrobacter genus belong to phylum Actinobacteria and are primarily soil-dwelling. Over 600 bacteriophages infecting hosts have been isolated sequenced, genomic analyses show these phages be highly diverse with mosaic genome architectures. We describe here a group of 32 grouped Cluster AZ, on four different strains all siphoviral morphologies. The AZ exhibit spectrum diversity can subdivided into subclusters. intracluster was analyzed in-depth at whole level through...
The professional identity of scientists has historically been cultivated to value research over teaching, which can undermine initiatives that aim reform science education. Course-Based Research Experiences (CRE) and the inclusive Education Communities (iREC) are two successful impactful efforts integrate teaching. this study is explicate instructors who implement a CRE within an established iREC explore how contributes success these programs. 97 from Science Alliance (SEA) participated in...
VOLUME 286 (2011) PAGES 30181–30189 The grant information footnote should read as follows. This work was supported, in whole or part, by National Institutes of Health Grants R01 CA42755 and CA85804 (to C. W. D.), AG031903 S. M.), T32 HL007147 J. K. GM007250 M.). “Acknowledgments” Dig2/RTP801 knock-out mice were obtained from Quark Pharmaceuticals, Inc., for whom they exclusively generated at Lexicon. We thank Tamotsu Yoshimori Noboru Mizushima providing LC3 cDNA Mark Jackson suggestions...
Alternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional translational interference results in isoform-dependent changes protein expression. Specifically, long undecoded (LUTI) is transcribed from gene-distal promoter, interfering with expression the gene-proximal promoter. While chromatin features associated LUTI have been described, mechanism underlying LUTI-based not...
ABSTRACT Seven bacteriophages were isolated from soil in Pennsylvania and Wisconsin using the host Microbacterium foliorum . These range number of predicted genes encoded, 25 to 91, are distributed across actinobacteriophage clusters EB, EC, EE, EK.
Course-based undergraduate research experiences (CUREs) provide a way for students to gain experience in classroom setting. Few examples of cell culture CUREs or online exist the literature.
BabyYoda and Lynlen are two cluster EB phages that were discovered at Thiel College using