A5077629794- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Genetics, Bioinformatics, and Biomedical Research
- Photosynthetic Processes and Mechanisms
- Microbial infections and disease research
- RNA and protein synthesis mechanisms
- Career Development and Diversity
- Photoreceptor and optogenetics research
- Light effects on plants
- Interdisciplinary Research and Collaboration
- Biomedical and Engineering Education
- Epigenetics and DNA Methylation
- Plant nutrient uptake and metabolism
- Histone Deacetylase Inhibitors Research
- Spaceflight effects on biology
- Innovative Teaching Methods
- Monoclonal and Polyclonal Antibodies Research
- Plant responses to elevated CO2
- Molecular Biology Techniques and Applications
- Evaluation of Teaching Practices
- Bioinformatics and Genomic Networks
- Toxoplasma gondii Research Studies
- Gene Regulatory Network Analysis
- Problem and Project Based Learning
Western Kentucky University
2011-2025
University of Kentucky
1989
University of Georgia
1981-1985
American Standard (United States)
1985
University of Wisconsin–Madison
1985
Brigham Young University
1977-1983
The bacteriophage population is vast, dynamic, old, and genetically diverse. genomics of phages that infect bacterial hosts in the phylum Actinobacteria show them to not only be diverse but also pervasively mosaic, replete with genes unknown function. To further explore this broad group bacteriophages, we describe here isolation genomic characterization 116 Microbacterium spp. Most are lytic, can grouped into twelve clusters according their overall relatedness; seven singletons no close...
Chromatin-modifying enzymes play a fundamental role in regulating chromatin structure so that DNA replication is spatially and temporally coordinated. For example, the lysine demethylase 4A/Jumonji domain-containing 2A (KDM4A/JMJD2A) tightly regulated during cell cycle. Overexpression of JMJD2A leads to altered timing faster S phase progression. In this study, we demonstrate degradation by proteasome. turnover coordinated through SKP1-Cul1-F-box ubiquitin ligase complex contains cullin 1...
Abstract Excess Phosphorus (P) in agriculture is causing serious environmental problems like eutrophication of lakes and rivers. Unlike the enormous information available for phosphate starvation response (P 0 ), very few effect excess P i on plants. Characterization Phosphate Response (EP R) essential designing strategies to increase accumulation tolerance. We show a significant modulation root developmental plasticity under increasing supply . An 20 mM ) produces shallow system...
ABSTRACT Genomic analysis of a large set phages infecting the common host Mycobacterium smegmatis mc 2 155 shows that they span considerable genetic diversity. There are more than 20 distinct types lack nucleotide similarity with each other, and there is diversity within most groups. Three newly isolated temperate mycobacteriophages, Bongo, PegLeg, Rey, constitute new group (cluster M), closely related Bongo PegLeg forming subcluster M1 distantly Rey M2. The cluster M mycobacteriophages have...
A report on research that explicates three models of pedagogical practice underpin and characterize inquiry instruction in a course-based experience.
Bacteriophages Xandras and BigBubba were isolated on Mycobacterium smegmatis mc 2 155 from enriched soil samples. Xandras' genome length is 75,179 bp with 144 predicted protein-coding genes two tRNAs. BigBubba's 75,006 147 Each contains a cyclic oligonucleotide sequestering protein (CBASS antagonist).
Infrastructure Network (KBRIN), have collaborated over the past decade to share research and educational expertise in bioinformatics.One result of this collaboration is joint sponsorship an annual regional summit bring together researchers, educators students who are interested bioinformatics from a variety institutions.This provides unique opportunities for forging links between members various year, Ninth Annual UT-ORNL-KBRIN Bioinformatics Summit was held at Lake Barkley State Park...
Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA amount have been reported. These generally differ amplitude and phase. The authors investigated how far parameter not regulated by clock can influence phase rhythm RNA arising from transcription. Using discrete-time approach, they modeled sinusoidal transcription with various constant exponential decay rates. They found that slower degradation, later compared transcriptional...
The photosynthetic enzyme ribulose bisphosphate carboxylase-oxygenase [EC 4.1.1.39] (RuBPCase) plays a key role in the carbon reduction system of plants. In this study, we determined kinetic variability RuBPCase among 46 varieties Hordeum vulgare L. at two ages. V(max) CO(2) and K(m) was for each cultivar. Varietal differences were found one four genotypes, respectively. One variety exhibited atypical behavior both V(max). A comparison age showed significant interaction between these factors...
Abstract Background Whole genome sequencing promises to revolutionize our ability link genotypic and phenotypic variation in a wide range of model non-model species. Results Here we describe the isolation characterization novel mycobacteriophage named BGlluviae that grows on Mycobacterium smegmatis mc 2 155. normally produces turbid plaques but spontaneous clear plaque was also recovered. The genomic DNA from pure populations phage mutant were sequenced. A single substitution, at amino acid...
Background Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii is a major cause of morbidity and mortality in patients with AIDS an important miscarriage, stillbirth congenital disease newborns. Previous studies have provided evidence that dietary supplementation vitamin E selenium harmful during experimental toxoplasmosis mice, whereas diet deficient results decreased numbers tissue cysts brain dramatically reduced pathology. The overall goal present study was to determine...
We report here the complete genome sequences of 44 phages infecting Arthrobacter sp. strain ATCC 21022. These have double-stranded DNA genomes with sizes ranging from 15,680 to 70,707 bp and G+C contents 45.1% 68.5%. All three tail types (belonging families Siphoviridae, Myoviridae, Podoviridae) are represented.
The light-dependent development of the photosynthetic apparatus in first leaf C(4) plant pearl millet (Pennisetum americanum) was monitored by immunologically determining concentration phospho-enolpyruvate carboxylase and ribulose 1,5-bisphosphate carboxylase. A competitive enzyme-linked immunosorbent assay procedure using antibodies to monomeric subunit phosphoenolpyruvate large small used quantitate amounts these polypeptides etiolated seedlings exposed light for varying periods time....
Over the last two decades, there have been numerous initiatives to improve undergraduate student outcomes in STEM. One model for scalable reform is inclusive Research Education Community (iREC). In an iREC, STEM faculty from colleges and universities across nation are supported adopt sustainably implement course-based research – a form of science pedagogy that enhances learning persistence science. this study, we used pathway modeling develop qualitative description explicates HHMI Science...
Background In order to develop treatments or preventive measures for auditory hair cell loss, an understanding of both the process regeneration and factors that influence this process, is needed. Our previous microarray analysis showed growth hormone (GH) was significantly upregulated during zebrafish regeneration, coupled with proliferation [1,2]. We further tested effects GH on by injecting after sound exposure found can efficiently promote post-trauma which may be achieved through...
Figure 1 BoxWhiskerChart of codon frequencies in phage without tRNA (blue boxes) and those with their genomes (red boxes).Colored boxes encompass the 25%-75% quantile while whiskers 0-25% 75-100% quantiles.Dark dots are outliers gray far outliers.The brown line is mean cyan median.The numbers on left margin represent number observations, n.