A5063439031- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Chemistry and Chemical Engineering
- Inorganic and Organometallic Chemistry
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Organometallic Complex Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Catalytic Alkyne Reactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Ammonia Synthesis and Nitrogen Reduction
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Nanomaterials for catalytic reactions
Roche (Switzerland)
2023-2025
ETH Zurich
2015-2020
Max-Planck-Institut für Kohlenforschung
2019-2020
We report diverse C-N cross-coupling reactions of aryl thianthrenium salts that are formed site-selectively by direct C-H functionalization. The scope N-nucleophiles ranges from primary and secondary alkyl amines to various N-containing heterocycles, the overall transformation is applicable late-stage functionalization complex, drug-like small molecules.
Herein, we report a two-step process forming arene C-O bonds in excellent site-selectivity at late-stage. The bond formation is achieved by selective introduction of thianthrenium group, which then converted into using photoredox chemistry. Electron-rich, -poor and -neutral arenes as well complex drug-like small molecules are successfully transformed both phenols various ethers. sequence differs conceptually from all previous oxygenation reactions that oxygen functionality can be...
A library of 29 homologous Ru-based olefin metathesis catalysts has been tested for ethenolysis cyclic olefins toward the goal selectively forming α,ω-diene using cis-cyclooctene as a prototypical substrate. Dissymmetry at N-heterocyclic carbene (NHC) ligand was identified key parameter controlling selectivity. The best-performing catalyst bearing an N-CF3 group significantly outperformed benchmark second-generation Grubbs in cis-cyclooctene. Application this optimal to various norbornenes...
Abstract Herein, we report a two‐step process forming arene C−O bonds in excellent site‐selectivity at late‐stage. The bond formation is achieved by selective introduction of thianthrenium group, which then converted into using photoredox chemistry. Electron‐rich, ‐poor and ‐neutral arenes as well complex drug‐like small molecules are successfully transformed both phenols various ethers. sequence differs conceptually from all previous oxygenation reactions that oxygen functionality can be...
Starting from N-trifluoromethyl benzimidazole (1), a series of benzimidazolium salts 2a–f·HA have been prepared and fully characterized. These were engaged in the formation [Ir(CO)2(NHC)Cl], [Rh(COD)(NHC)Cl], [Se(NHC)], [Au(NHC)Cl] derivatives. IR analysis [Ir(CO)2(NHC)Cl] complexes revealed that trifluoromethyl substituent on nitrogen significantly decreases σ-donating ability carbene carbon. On other hand, π-acceptor property these novel ligands is enhanced. Examination 77Se NMR resonance...
We report a nucleophilic substitution reaction of five-membered hetarylsulfonium salts that results in change the pattern on arene. The products these cine-substitutions are hard to access synthetically otherwise. sulfonium serve as starting materials generated by highly site-selective C-H functionalization reaction.
We report the synthesis of ruthenium metathesis catalysts containing unsymmetrical N-trifluoromethyl NHC ligands. These complexes have been fully characterized, and a Ru–F interaction has identified in solid state by X-ray crystallographic analysis for three with distances between 2.629(2) 2.652(2) Å. The influence ligands on initiation rates activation parameters was studied. activity these evaluated benchmark olefin reactions compared to standard second-generation Grubbs catalyst....
ADVERTISEMENT RETURN TO ISSUEPREVGreen Chemistry High...Green HighlightsNEXTGreen Articles of Interest to the Pharmaceutical IndustryMelissa A. AshleyMelissa AshleyGenentech Inc., 1 DNA Way, South San Francisco, California 94080, United StatesMore by Melissa Ashley, Miles H. AuklandMiles AuklandChemical Development, Technology & Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.More Aukland, Marian C. Bryan*Marian BryanJanssen R&D, 1400 McKean Road, Spring House, Pennsylvania 19002,...
Abstract A high throughput experimentation (HTE) study identified active Ru metathesis catalysts and reaction conditions for the ethenolysis of maleate esters to respective acrylate esters. Catalysts were tested at various loadings (75–10’000 ppm) temperatures (30–60 °C) with dissolved in toluene (up ca . 44 wt‐%) or neat variable partial pressures ethylene (0.2–10 bar). Ruthenium containing a PCy 3 ligand, such as 1st 2nd generation Grubbs catalysts, well state‐of‐the‐art cyclic alkyl amino...
ADVERTISEMENT RETURN TO ISSUEPREVGreen Chemistry High...Green HighlightsNEXTGreen Articles of Interest to the Pharmaceutical IndustryMelissa A. AshleyMelissa AshleyGenentech Inc., 1 DNA Way, South San Francisco, California 94080, United StatesMore by Melissa Ashley, Miles H. AuklandMiles AuklandChemical Development, Technology & Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.More Aukland, Marian C. Bryan*Marian BryanJanssen R&D, 1400 McKean Road, Spring House, Pennsylvania 19002,...