A5025206213- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Photoacoustic and Ultrasonic Imaging
- Image and Signal Denoising Methods
- Drug Transport and Resistance Mechanisms
- Protein Structure and Dynamics
- Biochemical effects in animals
- Advanced Image Fusion Techniques
- Alzheimer's disease research and treatments
- Neurobiology and Insect Physiology Research
- S100 Proteins and Annexins
- Olfactory and Sensory Function Studies
King's College London
2021-2024
Nanchang University
2020
Wuhan University
2020
Molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques intracellular tau neurofibrillary tangles Alzheimer's disease (AD). In addition, AD is characterized an increase astrocyte reactivity. The chaperone HSPB1 has been proposed a marker for reactive astrocytes; however, its astrocytic functions neurodegeneration remain to be elucidated. Here, we identify that secreted from astrocytes exert...
Abstract Astrocytes associate with amyloid plaques in Alzheimer's disease (AD). react to changes the brain environment, including increasing concentrations of amyloid‐β (Aβ). However, precise response astrocytes soluble small Aβ oligomers at similar those present human has not been addressed. In this study, we exposed media from neurons that express precursor protein ( APP) transgene double Swedish mutation (APPSwe), and which contains APP‐derived fragments, oligomers. We then used...
The accessory olfactory bulb (AOB), located at the posterior dorsal aspect of main (MOB), is first brain relay system (AOS), which can parallelly detect and process volatile nonvolatile social chemosignals mediate different sexual behaviors with (MOS). However, due to its anatomical location absence specific markers, there a lack research on internal external neural circuits AOB. This issue was addressed by single-color labeling fluorescent double using retrograde rAAVs injected into bed...
Image denoising, a fundamental step in image processing, has been widely studied for several decades. Denoising methods can be classified as internal or external depending on whether they exploit the prior noisy-clean priors to reconstruct latent image. Typically, these two kinds of have their respective merits and demerits. Using single denoising model improve existing remains challenge. In this paper, we propose method boosting effect via fusion strategy. This study aims boost performance...
Molecular chaperones have protective functions in neurodegeneration by preventing misfolding of aggregation-prone proteins. These been mostly studied neurons. However, members the family known as small heat shock proteins (sHSPs), including HSPB1, CRYAB, and HSPB8, are specifically expressed glial cells rather than neurons, their levels increase astrocytes human post-mortem Alzheimer's disease (AD) brain. While traditionally considered intracellular proteins, novel extracellular attributed...
Astrocytes are vital in the onset and progression of Alzheimer's disease (AD). Accumulation reactive astrocytes, together with tau phosphorylation, correlates very strongly cognitive decline. Molecular chaperones essential for maintaining protein homeostasis. One family small heat shock proteins (sHSPs), which include HSPB1 CRYAB. Expression these sHSPs seems to be restricted glial cells, levels found increase those astrocytes AD brains. The role that sHSP play is still not known. Emerging...