A5028085876- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Chemical Sensor Technologies
- Aquaculture Nutrition and Growth
- Memory and Neural Mechanisms
- Medical Image Segmentation Techniques
- Cell Image Analysis Techniques
- Human Pose and Action Recognition
- Clusterin in disease pathology
- Physiological and biochemical adaptations
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Animal Vocal Communication and Behavior
- Aquaculture disease management and microbiota
- Image Processing Techniques and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Healthcare and Venom Research
- Advanced Image and Video Retrieval Techniques
- Photoreceptor and optogenetics research
- Genetics and Neurodevelopmental Disorders
- Medicinal Plants and Neuroprotection
- Diet and metabolism studies
Huaqiao University
2025
Wuhan Institute of Physics and Mathematics
2013-2023
Wuhan National Laboratory for Optoelectronics
2023
Chinese Academy of Sciences
2013-2023
State Key Laboratory of Magnetism
2022-2023
University of Chinese Academy of Sciences
2013-2019
Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, whereas ventral tegmental area (VTA) dopaminergic (DAergic) neurons considered to be engaged motivation. Here, we found that VTA (DAergic)-mOT pathway could activated different types of naturalistic rewards as well odors DAT-cre mice. Optogenetic activation VTA-mOT DAergic fibers was able elicit...
Olfactory dysfunction is closely related to Alzheimer's disease (AD). Yet the mechanism behind this remains largely unknown. To clarify relationship between olfactory and memory deficits, we assessed behavioral system pathology in AβPP/PS1 transgenic mice using threshold test, Morris water maze, Western blotting, immunohistochemistry (IHC), thioflavine-s staining. blotting revealed following spatial-temporal deposition of amyloid-β (Aβ): appeared epithelium at 1-2 months old (mo); expanded...
s: The mammalian basal forebrain (BF), a heterogenous structure providing the primary cholinergic inputs to cortical and limbic structures, plays crucial role in various physiological processes such as learning/memory attention. Despite involvement of BF neurons (BFCNs) olfaction related memory has been reported, underlying neural circuits remain poorly understood. Here, we combined viral trans-synaptic tracing systems ChAT-cre transgenic mice systematically reveal relationship between...
Murine behavior recognition is widely used in biology, neuroscience, pharmacology, and other aspects of research, provides a basis for judging the psychological physiological state mice. To solve problem whereby traditional methods only model behavioral changes mice over time or space, we propose symmetrical algorithm that can capture spatiotemporal information based on changes. The first uses improved DeepLabCut keypoint detection to locate nose, left ear, right tail root mouse, then...
Abstract Food and predators are the most noteworthy objects for basic survival of wild animals, both often deviant in spatial temporal domains quickly attract an animal's attention. Although stimulus‐specific adaptation (SSA) is considered a potential neural basis salient sound detection domain, related research on visual SSA limited its relationship with saliency uncertain. The avian nucleus isthmi pars magnocellularis (Imc), which central to midbrain selective attention network, ideal site...
Electroacupuncture (EA) has been shown to enhance the recovery of symptoms in rheumatoid arthritis (RA); however, underlying mechanism remains unclear. Both pathogenesis RA and therapeutic effects EA are closely associated with metabolic activity brain. In this study, we investigated effect at "Zusanli" acupoint (ST36) on a rat model collagen-induced (CIA). The results demonstrated that effectively alleviated joint swelling, synovial hyperplasia, cartilage erosion, bone destruction CIA rats....
The accessory olfactory bulb (AOB), located at the posterior dorsal aspect of main (MOB), is first brain relay system (AOS), which can parallelly detect and process volatile nonvolatile social chemosignals mediate different sexual behaviors with (MOS). However, due to its anatomical location absence specific markers, there a lack research on internal external neural circuits AOB. This issue was addressed by single-color labeling fluorescent double using retrograde rAAVs injected into bed...
The extra copy of the methyl-CpG-binding protein 2 (MeCp2) gene causes MeCP2 duplication syndrome (MDS), a neurodevelopmental disorder characterized by intellectual disability and autistic phenotypes. However, disturbed microbiome metabolic profiling underlying autistic-like behavioral deficits MDS are rarely investigated. Here we aimed to understand contributions disruption associated alterations, especially neurotransmitters in employing transgenic mouse model with overexpression. We...
Glycogen synthase kinase 3β (GSK3β), a multifaceted kinase, is abundantly expressed in the brain, including olfactory bulb (OB). In resting cells, GSK3β constitutively active, and its over-activation presumably involved numerous brain diseases, such as Alzheimer’s disease. However, functions of active adult under physiological conditions are not well understood. Here, we studied possible activity OB. Odor stimulation, or blockade peripheral inputs caused by either transgenic knock-out ZnSO4...
Neuropeptide S (NPS) acts by activating its cognate receptor (NPSR). High level expression of NPSR in the posterior medial amygdala suggests that NPS-NPSR system should be involved regulation social behaviors induced pheromones. The present study was undertaken to investigate effects central administration NPS or with antagonist on alarm pheromone (AP)-evoked defensive and risk assessment mice. Furthermore, H129-H8, a novel high-brightness anterograde multiple trans-synaptic virus, c-Fos...
A series of oxime ester derivatives containing dehydroabietyl group were synthesized from dehydroabietic acid. Their structures characterized by IR, 1HNMR, MS, and elemental analysis. The preliminary antibacterial activity results indicate that these compounds display extensive anti-bacterial against Escherichia coli, Staphyloccocus aureu, Klebsiella pneumoniae, Pseudomonas aeruginosa, aerogenes epidermidis. Compounds (5a, 5b, 5c, 5d, 5e, 5f) exhibit excellent coli with the diameter...
The entire olfactory system, except for the sensory neurons in nasal cavity, is an intrinsic part of limb conferring olfaction many rarely known functions including regulation emotion, memory, and physiological psychological states, addition to general function smell. Meanwhile, innermost anatomical structures system lacking effective tools make study information coding, processing, transmission perception processes extremely difficult. functional magnetic resonance imaging (fMRI) has been...
Activity-dependent synaptic structural plasticity underlies the learning and memory. Mammals, especially rodents, are very sensitive to odorants, have considerable capability of odor Here, activity-dependent in olfactory bulb (OB) CNGA2 knock-out transgenic mice (CNGA2 KO), which is anosmic, was investigated. Using immunohistochemistry for specific presynaptic postsynaptic markers, it found that deficits peripheral inputs induced significant decreases expression synaptophysin, a general...
Clusterin, a protein involved in many biological processes, is expressed broadly the central nervous system, but its functions remain largely unknown. As preparations for elucidating some possible functions, we examined spatiotemporal expression patterns of clusterin mouse olfactory bulb at different developmental stages and under neuronal activity levels. Our results revealed dynamic during development. Clusterin signal was seemingly diffuse early development, shifted to cell somas later...