A5005201406- Ion Channels and Receptors
- Bladder and Urothelial Cancer Treatments
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Phytochemicals and Antioxidant Activities
- Advanced biosensing and bioanalysis techniques
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Chromosomal and Genetic Variations
- Heavy Metal Exposure and Toxicity
- Magnesium in Health and Disease
- Heart Rate Variability and Autonomic Control
- Trace Elements in Health
- Ethics and Legal Issues in Pediatric Healthcare
- Ion channel regulation and function
- Genetics and Neurodevelopmental Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Genomics and Phylogenetic Studies
- Urologic and reproductive health conditions
Heidelberg University
2020-2024
University of Rostock
2017-2021
Saarland University
2013
Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for lncRNAs that participate E2F1-activated prometastatic GRNs phenotypic targets the highly-relevant case E2F1-driven aggressive bladder cancer (BC). RNA immunoprecipitation was...
Human endogenous retroviruses (HERVs) of the HERV-W group comprise hundreds loci in human genome. Deregulated expression and locus ERVWE1-encoded Syncytin-1 protein have been implicated pathogenesis multiple sclerosis (MS). However, actual transcription MS context has not comprehensively analyzed. We investigated brain lesions white matter tissue from healthy controls by employing next-generation amplicon sequencing env-specific reverse transcriptase (RT) PCR products, thus revealing...
Bladder cancer progression has been associated with dysfunctional repair of double-strand breaks (DSB), a deleterious type DNA lesions that fuel genomic instability. Accurate DSB relies on two distinct pathways, homologous recombination (HR) and classical non-homologous end-joining (c-NHEJ). The transcription factor E2F1 supports HR-mediated protects stability. However, invasive bladder cancers (BC) display, in contrast to non-invasive stages, instability despite their high levels. Hence, is...
Mechanisms governing tumor progression differ from those of initiation. One enigmatic prometastatic process is the recapitulation pathways neural plasticity in aggressive stages. Cancer and neuronal cells develop reciprocal interactions via mutual production secretion growth factors, neurothrophins and/or axon guidance molecules microenvironment. Understanding cancer types where this active, as well drivers, markers underlying mechanisms, has great significance for blocking improving patient...
TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. expressed in cardiac cells including fibroblasts (CFs) have been implicated development pathological remodeling fibrosis. Using Ca2+ imaging several compound knockout mouse lines we analyzed involvement for angiotensin II (AngII)-induced changes homeostasis CFs isolated from adult mice. qPCR detected transcripts all Trpc genes CFs; Trpc1, Trpc3 Trpc4 being most...
Pathological cardiac remodeling correlates with chronic neurohumoral stimulation and abnormal Ca2+ signaling in cardiomyocytes. Store-operated calcium entry (SOCE) has been described adult neonatal murine cardiomyocytes, Orai1 proteins act as crucial ion-conducting constituents of this pathway that can be engaged not only by passive store depletion but also stimuli such angiotensin-II. In study, we, therefore, analyzed the consequences deletion for cardiomyocyte hypertrophy cardiomyocytes...
Early embryogenesis depends on proper control of intracellular homeostasis ions including Ca2+ and Mg2+. Deletion the Mg2+ conducting TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization, blastocoel formation, correct specification lineages trophectoderm inner cell mass unaltered despite that free cytoplasmic reduced at two-cell stage. Although Trpm7-/- embryos are able to hatch from zona pellucida, no expansion trophoblast cells can be observed, not...
Double strand break (DSB) repair mechanisms guard genome integrity and their deterioration causes genomic instability. Common rare fragile sites (CFS RFS, respectively) are particularly vulnerable to instability, there is an inverse correlation between site (FS) expression DSB protein levels. Upon dysfunction, genes residing at these greater risk of deregulation compared located non-FS. In this regard, it remains enigmatic why the incidence miRNA FS higher Herein, using bioinformatics, we...
Figure S5. OS of BC patients with a high E2F1/high APLF tumor content upon elevated mRNA expression the c-NHEJ complex factors. (PDF 2143 kb)