A5101983723- Inflammatory mediators and NSAID effects
- Proteins in Food Systems
- Monoclonal and Polyclonal Antibodies Research
- Dental Health and Care Utilization
- Radiopharmaceutical Chemistry and Applications
- Protein Hydrolysis and Bioactive Peptides
- Nitric Oxide and Endothelin Effects
- Phytase and its Applications
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Oral microbiology and periodontitis research
- Biotin and Related Studies
- Bone Tissue Engineering Materials
- HER2/EGFR in Cancer Research
- Mitochondrial Function and Pathology
- Vanadium and Halogenation Chemistry
- Temporomandibular Joint Disorders
- Chemical synthesis and alkaloids
- Peptidase Inhibition and Analysis
- Heart Rate Variability and Autonomic Control
- NF-κB Signaling Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Amphibian and Reptile Biology
- Fluorine in Organic Chemistry
Hiroshima University
2005-2023
Health Research Foundation
2017-2022
Tokyo Institute of Technology
2022
Yamamoto Hospital
2022
Tokyo Medical and Dental University
2019-2021
Juntendo University Shizuoka Hospital
2019
Takeda (Japan)
2012-2013
Kagoshima University
2005-2010
Prefectural University of Hiroshima
2010
Nagoya University
2010
Background Although both clinical and animal studies have shown that ischemic tolerance is reduced in the senescent myocardium, it has not been clarified when myocardium becomes more vulnerable to ischemia. Preconditioning protects hearts of young adult animals various species, but its effects are identical human studies. We investigated whether effect preconditioning decreased isolated middle-aged rats. Methods Results The rats (12 weeks old: group Y, n=44) (50 M, were subjected global...
α-Lactalbumin (α-LA) was glycated with maltopentaose (MP) through the Maillard reaction (MP-α-LA) and subsequently phosphorylated by dry heating in presence of pyrophosphate to investigate its structure physiological functions. Glycation occurred effectively, sugar content α-LA increased approximately 22.3% reaction. The phosphorylation MP-α-LA enhanced an increase dry-heating time from 1 5 d, phosphorous 1.01% at pH 4.0 85°C for d pyrophosphate. electrophoretic mobility level. circular...
Regenerative therapy for tissues by mesenchymal stem cell (MSCs) transplantation has received much attention. The cluster of differentiation (CD)146 marker, a surface-antigen cells, is crucial angiogenic and osseous abilities. Bone regeneration accelerated the CD146-positive deciduous dental pulp-derived cells contained in from human exfoliated teeth (SHED) into living donor. However, role CD146 SHED remains unclear. This study aimed to compare effects on proliferative substrate metabolic...
We determined the complete nucleotide sequences of mitochondrial (mt) genomes from two dicroglossid frogs, Hoplobatrachus tigerinus (Indian Bullfrog) and Euphlyctis hexadactylus Green frog). The genome sizes are 20462 bp in H. 20280 E. hexadactylus. Although both encode typical 37 mt genes, following unique features observed: 1) ND5 genes duplicated that have completely identical sequences, whereas possessed dissimilar substitutions; 2) control region (CR) has almost single was found...
Ovalbumin (OVA) was phosphorylated by dry-heating in the presence of pyrophosphate at pH 4.0 and 85 °C for 1 5 days, physicochemical structural properties OVA were investigated. The phosphorus content increased to 1.01% phosphorylation, electrophoretic mobility PP-OVA also increased. Although solubility dry-heated decreased, decrease slightly depressed phosphorylation. circular dichroism spectra showed that change secondary structure molecule, as measured α-helix content, mild exchange...
The purpose of this study was to examine the simultaneous interrelationships oral health behavior and between mothers their children using linear structural relations (LISREL) program. subjects comprised 117 pairs aged 8 11 years. Dental status expressed as DMFT. Oral Rating Index (ORI) for ORI (ORI-C) were used measures gingival health. Hiroshima University Behavioral Inventory (HU-DBI) assessment mothers' behavior. HU-DBI had a direct positive relationship ORI, negative DFT, association...
Traditionally, chemistry has been developed to obtain thermodynamically stable and isolable compounds such as molecules solids by chemical reactions. However, recent developments in computational have placed increased importance on studying the dynamic assembly disassembly of atoms formed situ. This study directly visualizes formation dissociation dynamics labile dimers trimers at atomic resolution with elemental identification. The video recordings many homo- hetero-metallic are carried out...
The first total synthesis of murrastifoline-A (1), a biscarbazole alkaloid is described.The skeleton 1 was effectively constructed by the Pd-catalyzed double N-arylation carbazolamine (bottomhalf segment, 3) with dibromobiphenyl derivative (top-half 2) in onestep reaction.Both segments were synthesized starting from 2-amino-5methylphenol (4).Carbazole alkaloids are known to show wide range biological activities such as antitumor, antibiotic, psychotropic, antiinflammatory, and antihistaminic...