A5032559730- Bone Tissue Engineering Materials
- Bone health and treatments
- Bone Metabolism and Diseases
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bone and Dental Protein Studies
- Orthopedic Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Orthopaedic implants and arthroplasty
Technische Universität Dresden
2022-2025
University Hospital Carl Gustav Carus
2023-2025
Macrophages and osteocytes are important regulators of inflammation, osteogenesis osteoclastogenesis. However, their interactions under adverse conditions, such as biomaterial-associated infection (BAI) not fully understood. We aimed to elucidate how factors released from macrophages modulate osteocyte responses in an vitro indirect 3D co-culture model. Human monocyte-derived were cultured on etched titanium disks activated with either IL-4 cytokine (anti-inflammatory M2 phenotype) or...
3D extrusion bioprinting, a promising and widely adopted technology in the emerging field of biofabrication, has gained considerable attention for its ability to fabricate hierarchically structured, native-mimicking tissue substitutes with precisely defined cell distributions. Despite notable advancements, limited availability suitably bioactive bioinks remains major challenge, hindering construction volumetric effectively mimicking biological functionality. Therefore, this work proposes...
Bone remodelling, important for homeostasis and regeneration involves the controlled action of osteoblasts, osteocytes osteoclasts. The present study established a three-dimensional human
An in vitro bone triple culture involving human primary osteoblasts, osteocytes and osteoclasts enables the investigation of healing factors, drugs or biomaterials a model system for native tissue. The present study analyses impact Sr2+ as well hypoxic cultivation (5% O2 content chemically induced by Co2+) on cells. three cell types were cultivated together presence 100 µM Sr2+, conditions 75 Co2+. After separated analysed mRNA protein level individually. In response to osteoblasts showed...