A5102928799- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Mosquito-borne diseases and control
- Pneumonia and Respiratory Infections
- Neuropeptides and Animal Physiology
- Macrophage Migration Inhibitory Factor
- Respiratory viral infections research
- Acute Lymphoblastic Leukemia research
- Nanowire Synthesis and Applications
- Receptor Mechanisms and Signaling
- Virus-based gene therapy research
Emory University
2022-2024
Bipar
2024
University of Alabama
2020-2021
Respiratory viral infections remain a leading cause of morbidity and mortality. Using murine model human metapneumovirus (HMPV), we identified recruitment C1q-expressing inflammatory monocyte population concomitant with clearance by adaptive immune cells. Genetic ablation C1q led to reduced CD8+ T cell function. Production myeloid lineage was necessary enhance Activated dividing cells expressed receptor, gC1qR. Perturbation gC1qR signaling altered IFN-γ production, metabolic capacity,...
Siglec-15 (Sig15) has been implicated as an immune checkpoint expressed in solid tumor-infiltrating macrophages and is being targeted clinical trials with mAbs to normalize the tumor microenvironment stimulate antitumor immunity. However, role of Sig15 hematologic malignancies remains undefined. mRNA protein expression levels were determined from publicly available databases, cell lines, primary patient samples. Human B-cell acute lymphoblastic leukemia (B-ALL) lines used identify signaling...
2558 Background: Chimeric antigen receptor (CAR) T therapies for pancreatic ductal adenocarcinoma (PDAC) still face significant immunosuppressive obstacles in the tumor microenvironment (TME). We hypothesize that an optimal CAR cell PDAC combines targeting ideal tumor-associated (TAA) and overcomes unique immunosuppression TME. The retained ectodomain of Muc16 (Muc16CD) is a known TAA ovarian cancer but has yet to be explored cancer. Vasoactive intestinal peptide (VIP) emerging checkpoint...
Abstract Advanced age in humans is associated with greater susceptibility to and higher mortality rates from infections, including infections some RNA viruses. The underlying innate immune mechanisms, which represent the first line of defense against pathogens, remain incompletely understood. Drosophila melanogaster able mount potent evolutionarily conserved defenses a variety microorganisms viruses serves as an excellent model organism for studying host–pathogen interactions. With its...
Summary Advanced age in humans is associated with greater susceptibility to and higher mortality rates from infections, including infections some RNA viruses. The underlying innate immune mechanisms, which represent the first line of defense against pathogens, remain incompletely understood. Drosophila melanogaster able mount potent evolutionarily conserved defenses a variety microorganisms viruses serves as an excellent model organism for studying host-pathogen interactions. With its...
<h3>Background</h3> Chimeric antigen receptor (CAR) T cell therapies have shown remarkable clinical efficacy in hematological cancers, but still face significant obstacles the treatment of solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Two hurdles developing effective CAR for PDAC are identification ideal tumor-associated antigens (TAA) to target and overcoming a complex tumor microenvironment (TME). We hypothesize that optimal treat both recognizes an TAA is protected from...