A5048378635- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Tannin, Tannase and Anticancer Activities
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Chronic Myeloid Leukemia Treatments
- Prostate Cancer Treatment and Research
- T-cell and Retrovirus Studies
- Glycosylation and Glycoproteins Research
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Bone health and treatments
- Bone and Dental Protein Studies
Emory University
2019-2024
Brookline Public Schools
2024
Clark Atlanta University
2016-2021
Center for Cancer Research
2016-2021
Emory and Henry College
2020
Children's Healthcare of Atlanta
2020
Cancer Institute (WIA)
2020
NewYork–Presbyterian Brooklyn Methodist Hospital
2012
Peroxidasin (PXDN), a human homolog of Drosophila PXDN, belongs to the family heme peroxidases and has been found promote oxidative stress in cardiovascular tissue, however, its role prostate cancer not previously elucidated. We hypothesized that PXDN promotes progression via regulation metabolic pathways. analyzed expression tissue by immunohistochemistry increased with as compared normal or cells. knockdown followed proteomic analysis revealed an increase stress, mitochondrial dysfunction...
The epithelial mesenchymal transition (EMT) promotes tumor migration and invasion by downregulating markers such as E-cadherin upregulating vimentin. Cathepsin L (Cat L) is a cysteine protease that can proteolytically activate CCAAT displacement protein/cut homeobox transcription factor (CUX1). We hypothesized nuclear Cat may promote EMT via CUX1 this could be antagonized with the L-specific inhibitor Z-FY-CHO. Mesenchymal prostate (ARCaP-M ARCaP-E overexpressing Snail) breast (MDA-MB-468,...
Abstract Immunotherapies have revolutionized the treatment of B-cell acute lymphoblastic leukemia (B-ALL), but duration responses is still sub-optimal. We sought to identify mechanisms immune suppression in B-ALL and strategies overcome them. Plasma collected from children with measurable residual disease after induction chemotherapy showed differential cytokine expression, particularly IL-7, while single-cell RNA-sequencing revealed expression genes associated exhaustion cell subsets. also...
Siglec-15 (Sig15) has been implicated as an immune checkpoint expressed in solid tumor-infiltrating macrophages and is being targeted clinical trials with mAbs to normalize the tumor microenvironment stimulate antitumor immunity. However, role of Sig15 hematologic malignancies remains undefined. mRNA protein expression levels were determined from publicly available databases, cell lines, primary patient samples. Human B-cell acute lymphoblastic leukemia (B-ALL) lines used identify signaling...
Exploitation of the immune system has emerged as an important therapeutic strategy for acute lymphoblastic leukemia (ALL). However, mechanisms evasion during progression remain poorly understood. We sought to understand role calcineurin in ALL and observed that depletion B (CnB) cells dramatically prolongs survival immune-competent but not immune-deficient recipients. Immune-competent recipients were protected from challenge with if they first immunized CnB-deficient leukemia, suggesting...
Therapies that bind with immune cells and redirect their cytotoxic activity toward diseased represent a promising versatile approach to immunotherapy applications in cancer, lupus, other diseases; traditional methods for discovering these therapies, however, are often time-intensive lack the throughput of related target-based discovery approaches. Inspired by observation cytokine, IL-12, can enhance antileukemic clinically approved T cell redirecting therapy, blinatumomab, here we describe...
Abstract Prostate cancer (PCa) patients’ mortality is mainly attributed to complications caused by metastasis of the tumor cells organs critical for survival, such as bone. We hypothesized that PCa cell‐bone interactions would promote paracrine signaling. A panel cell lines were cocultured with hydroxyapatite ([HA]; inorganic component bone) different densities. Conditioned media (CM) was collected and analyzed calcium levels effect on signaling, migration, viability in vitro vivo. Our...
ABSTRACT Therapies that bind with immune cells and redirect their cytotoxic activity towards diseased represent a promising versatile approach to immunotherapy applications in cancer, lupus, other diseases; traditional methods for discovering these therapies, however, are often time-intensive lack the throughput of related target-based discovery approaches. Inspired by observation cytokine, IL-12, can enhance antileukemic clinically approved T cell redirecting therapy, blinatumomab, here we...
Abstract Macrophages engulf apoptotic bodies and cellular debris as part of homeostasis, but they can also phagocytose live cells such aged red blood cells. Pharmacologic reprogramming with the SMAC mimetic LCL161 in combination T cell-derived cytokines induce macrophages to cancer mouse models. Here we extend these findings encompass a wide range monovalent bivalent compounds, demonstrating that cell phagocytosis is class effect agents. We demonstrate robust pancreatic breast by primary...
Abstract Prostate cancer (PCa) is the most frequently diagnosed in men, second leading cause of male deaths U.S, and also presents greatest racial disparity any U.S. The incidence mortality PCa higher African-American men (AA), compared to other ethnic groups. Epithelial Mesenchymal Transition (EMT) a key event tumor migration invasion processes whereby epithelial cells lose polarity together with cell-cell contacts associated loss markers such as E-cadherin then undergo dramatic remodeling...
Abstract Prostate cancer is the most diagnosed in men and second leading cause of death United States. African American have highest incidence mortality rates prostate compared to any other race. Epithelial-mesenchymal transition (EMT) plays a critical role progression metastasis. Mesenchymal cells are migratory, invasive, more resistant apoptosis. Reactive Oxygen Species (ROS) has been shown promote EMT. High mobility group A (HMGA2) non-histone protein that highly expressed during...
<p>SF1: Leukemia model SF2: Data from individual mice SF3: Flow cytometry gating strategy SF4: Immunomodulatory Molecules SF5: Cytokine arrays</p>
<p>Supplemental Table 2: Pathways analysis of RNA-seq using DAVID.</p>
<p>Supplemental Table 1: Gene expression analysis by RNA-seq from shNS and shCnB leukemia cells. Data are normalized as Reads per Kilobase Million.</p>
<p>Supplemental Table 2: Pathways analysis of RNA-seq using DAVID.</p>
<div>Abstract<p>Exploitation of the immune system has emerged as an important therapeutic strategy for acute lymphoblastic leukemia (ALL). However, mechanisms evasion during progression remain poorly understood. We sought to understand role calcineurin in ALL and observed that depletion B (CnB) cells dramatically prolongs survival immune-competent but not immune-deficient recipients. Immune-competent recipients were protected from challenge with if they first immunized...
<p>SF1: Leukemia model SF2: Data from individual mice SF3: Flow cytometry gating strategy SF4: Immunomodulatory Molecules SF5: Cytokine arrays</p>
<p>Supplemental Table 1: Gene expression analysis by RNA-seq from shNS and shCnB leukemia cells. Data are normalized as Reads per Kilobase Million.</p>